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Lack of association between serum syndecan-4, myocardial fibrosis and ventricular dysfunction in subjects with chronic Chagas disease.

Abstract Syndecan-4 is a transmembrane glycoprotein associated with inflammation and fibrosis. Increased syndecan-4 levels were previously detected after acute myocardial infarction and in subjects with heart failure. However, the levels of syndecan-4 in subjects with Chagas disease have not so far been investigated. The aim of this study was to investigate the potential role of serum sydencan-4 as a novel biomarker for myocardial fibrosis and cardiac dysfunction in subjects with Chagas disease.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos one
Publication Year Start




PMID- 29232393
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20180104
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 12
DP  - 2017
TI  - Lack of association between serum syndecan-4, myocardial fibrosis and ventricular
      dysfunction in subjects with chronic Chagas disease.
PG  - e0189408
LID - 10.1371/journal.pone.0189408 [doi]
AB  - BACKGROUND: Syndecan-4 is a transmembrane glycoprotein associated with
      inflammation and fibrosis. Increased syndecan-4 levels were previously detected
      after acute myocardial infarction and in subjects with heart failure. However,
      the levels of syndecan-4 in subjects with Chagas disease have not so far been
      investigated. The aim of this study was to investigate the potential role of
      serum sydencan-4 as a novel biomarker for myocardial fibrosis and cardiac
      dysfunction in subjects with Chagas disease. METHODS: This study comprised
      subjects with Chagas disease (n = 56), being 14 (25%) with the indeterminate
      form, 16 (29%) with the cardiac form without ventricular dysfunction, and 26
      (46%) with the cardiac form with ventricular dysfunction. RESULTS: Syndecan-4
      serum concentrations did not correlate with presence or absence of myocardial
      fibrosis (P = 0.386) nor disease severity in subjects with Chagas disease (P =
      0.918). Additionally, no correlation was found either between the degree of
      myocardial fibrosis and serum syndecan-4 [r = 0.08; P = 0.567] or between left
      ventricular ejection fraction and syndecan-4 [r = 0.02; P = 0.864]. In contrast, 
      NT-proBNP levels correlated with ejection fraction and myocardial fibrosis.
      CONCLUSIONS: Our results demonstrate the lack of correlations between serum
      syndecan-4, myocardial fibrosis and cardiac dysfunction in subjects with Chagas
      disease. Further studies are required to show if syndecan-4 concentrations can be
      marker for prognosis assessment or disease progression.
FAU - Larocca, Ticiana Ferreira
AU  - Larocca TF
AD  - Center for Biotechnology and Cell Therapy, Sao Rafael Hospital, Salvador, Bahia, 
      Brazil.
AD  - Goncalo Moniz Institute, IGM-Fiocruz/BA, Salvador, Bahia, Brazil.
FAU - Macedo, Carolina The
AU  - Macedo CT
AD  - Center for Biotechnology and Cell Therapy, Sao Rafael Hospital, Salvador, Bahia, 
      Brazil.
AD  - Department of Cardiology, Sao Rafael Hospital, Salvador, Bahia, Brazil.
FAU - Noya-Rabelo, Marcia
AU  - Noya-Rabelo M
AD  - Department of Cardiology, Sao Rafael Hospital, Salvador, Bahia, Brazil.
FAU - Lemos Correia, Luis Claudio
AU  - Lemos Correia LC
AD  - Department of Cardiology, Sao Rafael Hospital, Salvador, Bahia, Brazil.
AD  - Escola Bahiana de Medicina e Saude Publica, Salvador, Bahia, Brazil.
FAU - Moreira, Moises Imbassahy
AU  - Moreira MI
AD  - Department of Cardiology, Sao Rafael Hospital, Salvador, Bahia, Brazil.
FAU - Caldas, Alessandra Carvalho
AU  - Caldas AC
AD  - Department of Cardiology, Sao Rafael Hospital, Salvador, Bahia, Brazil.
FAU - Torreao, Jorge Andion
AU  - Torreao JA
AD  - Department of Cardiology, Sao Rafael Hospital, Salvador, Bahia, Brazil.
FAU - Souza, Bruno Solano de Freitas
AU  - Souza BSF
AD  - Center for Biotechnology and Cell Therapy, Sao Rafael Hospital, Salvador, Bahia, 
      Brazil.
AD  - Goncalo Moniz Institute, IGM-Fiocruz/BA, Salvador, Bahia, Brazil.
FAU - Vasconcelos, Juliana Fraga
AU  - Vasconcelos JF
AD  - Center for Biotechnology and Cell Therapy, Sao Rafael Hospital, Salvador, Bahia, 
      Brazil.
AD  - Goncalo Moniz Institute, IGM-Fiocruz/BA, Salvador, Bahia, Brazil.
FAU - Carvalho da Silva, Alexandre Schaer
AU  - Carvalho da Silva AS
AD  - Center for Biotechnology and Cell Therapy, Sao Rafael Hospital, Salvador, Bahia, 
      Brazil.
FAU - Ribeiro Dos Santos, Ricardo
AU  - Ribeiro Dos Santos R
AD  - Center for Biotechnology and Cell Therapy, Sao Rafael Hospital, Salvador, Bahia, 
      Brazil.
FAU - Soares, Milena Botelho Pereira
AU  - Soares MBP
AUID- ORCID: http://orcid.org/0000-0003-3363-3544
AD  - Center for Biotechnology and Cell Therapy, Sao Rafael Hospital, Salvador, Bahia, 
      Brazil.
AD  - Goncalo Moniz Institute, IGM-Fiocruz/BA, Salvador, Bahia, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20171212
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Syndecan-4)
SB  - IM
MH  - Aged
MH  - Cardiomyopathies/*blood/complications
MH  - Chagas Disease/blood/*physiopathology
MH  - Chronic Disease
MH  - Female
MH  - Fibrosis/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Syndecan-4/*blood
PMC - PMC5726626
EDAT- 2017/12/13 06:00
MHDA- 2018/01/05 06:00
CRDT- 2017/12/13 06:00
PHST- 2017/02/16 00:00 [received]
PHST- 2017/11/25 00:00 [accepted]
PHST- 2017/12/13 06:00 [entrez]
PHST- 2017/12/13 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
AID - 10.1371/journal.pone.0189408 [doi]
AID - PONE-D-17-06395 [pii]
PST - epublish
SO  - PLoS One. 2017 Dec 12;12(12):e0189408. doi: 10.1371/journal.pone.0189408.
      eCollection 2017.