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The self-curing phenomenon of schistosome infection in rhesus macaques: insight from in vitro studies.

Abstract A reduction in the burden of schistosomiasis is potentially achievable by integrating a schistosomiasis vaccine with current control measures. Here, we determine parasite-specific in vitro responses of B, T, and NK cells from naive uninfected rhesus macaques to Schistosoma mansoni (Sm) egg (SmEA) and worm antigen (SmWA) preparations isolated from infected baboons. Pronounced B cell responses to SmEA and NK cell responses to both SmEA and SmWA were observed. High levels of IL-2 and IL-21 responses against Sm antigens were observed in T and non-T cells of lymph nodes (LNs) and gut lamina propria-derived lymphocytes (LPLs). Data analysis showed multifunctionality of LN-derived CD4+ , CD8+ , and CD4+ CD8+ double positive T cells against either SmWA or SmWA+SmEA antigen preparations. Distinct SmEA-specific multifunctional responses were observed in gut LPLs, suggesting simultaneous responses against egg antigens. These data provide insight into the immune effectors involved in schistosome responses by rhesus macaques.
PMID
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Authors

Mayor MeshTerms
Keywords

Schistosoma mansoni

lamina propria-derived leukocytes (LPLs)

lymph nodes (LNs)

peripheral blood mononuclear cells (PBMCs)

rhesus macaques

schistosome infection

self-curing mechanisms

Journal Title annals of the new york academy of sciences
Publication Year Start




PMID- 29239481
OWN - NLM
STAT- MEDLINE
DCOM- 20171227
LR  - 20171227
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1408
IP  - 1
DP  - 2017 Nov
TI  - The self-curing phenomenon of schistosome infection in rhesus macaques: insight
      from in vitro studies.
PG  - 79-89
LID - 10.1111/nyas.13565 [doi]
AB  - A reduction in the burden of schistosomiasis is potentially achievable by
      integrating a schistosomiasis vaccine with current control measures. Here, we
      determine parasite-specific in vitro responses of B, T, and NK cells from naive
      uninfected rhesus macaques to Schistosoma mansoni (Sm) egg (SmEA) and worm
      antigen (SmWA) preparations isolated from infected baboons. Pronounced B cell
      responses to SmEA and NK cell responses to both SmEA and SmWA were observed. High
      levels of IL-2 and IL-21 responses against Sm antigens were observed in T and
      non-T cells of lymph nodes (LNs) and gut lamina propria-derived lymphocytes
      (LPLs). Data analysis showed multifunctionality of LN-derived CD4(+) , CD8(+) ,
      and CD4(+) CD8(+) double positive T cells against either SmWA or SmWA+SmEA
      antigen preparations. Distinct SmEA-specific multifunctional responses were
      observed in gut LPLs, suggesting simultaneous responses against egg antigens.
      These data provide insight into the immune effectors involved in schistosome
      responses by rhesus macaques.
CI  - (c) 2017 New York Academy of Sciences.
FAU - Torben, Workineh
AU  - Torben W
AD  - Tulane National Primate Research Center, TNPRC, Comparative Pathology/Immunology,
      Tulane University Health Sciences Center, Covington, Louisiana.
FAU - Molehin, Adebayo J
AU  - Molehin AJ
AD  - Center for Tropical Medicine and Infectious Diseases, Department of Internal
      Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.
FAU - Blair, Robert V
AU  - Blair RV
AD  - Tulane National Primate Research Center, TNPRC, Comparative Pathology/Immunology,
      Tulane University Health Sciences Center, Covington, Louisiana.
FAU - Kenway, Carys
AU  - Kenway C
AD  - Tulane National Primate Research Center, TNPRC, Comparative Pathology/Immunology,
      Tulane University Health Sciences Center, Covington, Louisiana.
FAU - Shiro, Faith
AU  - Shiro F
AD  - Tulane National Primate Research Center, TNPRC, Comparative Pathology/Immunology,
      Tulane University Health Sciences Center, Covington, Louisiana.
FAU - Roslyn, Davis
AU  - Roslyn D
AD  - Tulane National Primate Research Center, TNPRC, Comparative Pathology/Immunology,
      Tulane University Health Sciences Center, Covington, Louisiana.
FAU - Chala, Bayissa
AU  - Chala B
AD  - Department of Applied Biology, Adama Science and Technology University, School of
      Applied Natural Sciences, Adama, Ethiopia.
FAU - Gutu, Dereje
AU  - Gutu D
AD  - Department of Veterinary Medicine, Jimma University, Jimma, Ethiopia.
FAU - Kebede, Michael A
AU  - Kebede MA
AD  - Department of Epidemiology & Biostatistics, George Washington University,
      Washington, DC.
FAU - Ahmad, Gul
AU  - Ahmad G
AD  - Department of Biology, Peru State College, Peru, Nebraska.
FAU - Zhang, Weidong
AU  - Zhang W
AD  - Center for Tropical Medicine and Infectious Diseases, Department of Internal
      Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.
FAU - Aye, Pyone
AU  - Aye P
AD  - Tulane National Primate Research Center, TNPRC, Comparative Pathology/Immunology,
      Tulane University Health Sciences Center, Covington, Louisiana.
FAU - Mohan, Mahesh
AU  - Mohan M
AD  - Tulane National Primate Research Center, TNPRC, Comparative Pathology/Immunology,
      Tulane University Health Sciences Center, Covington, Louisiana.
FAU - Lackner, Andrew
AU  - Lackner A
AD  - Tulane National Primate Research Center, TNPRC, Comparative Pathology/Immunology,
      Tulane University Health Sciences Center, Covington, Louisiana.
FAU - Siddiqui, Afzal A
AU  - Siddiqui AA
AD  - Center for Tropical Medicine and Infectious Diseases, Department of Internal
      Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Antigens, Helminth)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukins)
RN  - 0 (interleukin-21)
SB  - IM
MH  - Animals
MH  - Antigens, Helminth/*immunology
MH  - B-Lymphocytes/immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Interleukin-2/immunology/metabolism
MH  - Interleukins/immunology/metabolism
MH  - Killer Cells, Natural/immunology
MH  - Lymph Nodes/immunology
MH  - Macaca mulatta
MH  - Monkey Diseases/*immunology/parasitology
MH  - Papio
MH  - Remission, Spontaneous
MH  - Schistosoma mansoni/*immunology/physiology
MH  - Schistosomiasis mansoni/*immunology/parasitology/*veterinary
OTO - NOTNLM
OT  - Schistosoma mansoni
OT  - lamina propria-derived leukocytes (LPLs)
OT  - lymph nodes (LNs)
OT  - peripheral blood mononuclear cells (PBMCs)
OT  - rhesus macaques
OT  - schistosome infection
OT  - self-curing mechanisms
EDAT- 2017/12/15 06:00
MHDA- 2017/12/28 06:00
CRDT- 2017/12/15 06:00
PHST- 2017/09/12 00:00 [received]
PHST- 2017/10/25 00:00 [revised]
PHST- 2017/10/31 00:00 [accepted]
PHST- 2017/12/15 06:00 [entrez]
PHST- 2017/12/15 06:00 [pubmed]
PHST- 2017/12/28 06:00 [medline]
AID - 10.1111/nyas.13565 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2017 Nov;1408(1):79-89. doi: 10.1111/nyas.13565.