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Tonsillar metastasis of nonsmall cell lung cancer with G719S mutation in exon 18: A case report.

Abstract Lung cancer has the highest mortality of all malignant tumors and is becoming the leading cause of death in China. Surgical resection is the best treatment for early non-small-cell lung carcinoma. But postoperative tumor recurrence is very common. Brain, bone and liver are the most common metastatic sites of lung cancer.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29245278
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20180105
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 49
DP  - 2017 Dec
TI  - Tonsillar metastasis of nonsmall cell lung cancer with G719S mutation in exon 18:
      A case report.
PG  - e9003
LID - 10.1097/MD.0000000000009003 [doi]
AB  - RATIONALE: Lung cancer has the highest mortality of all malignant tumors and is
      becoming the leading cause of death in China. Surgical resection is the best
      treatment for early non-small-cell lung carcinoma. But postoperative tumor
      recurrence is very common. Brain, bone and liver are the most common metastatic
      sites of lung cancer. PATIENT CONCERNS: A 59-year-old woman was admitted to our
      hospital finding a lung nodule in physical examination. No other obvious symptoms
      were obsessed in this patient. No remarkable abnormality was detected in
      preoperative laboratory tests and physical examination. DIAGNOSES: A ground-glass
      nodule was detected on the left inferior lobe in the imaging examination. No
      metastases were detected before the surgery and early-stage lung cancer was
      supposed. INTERVENTION: This patient underwent a radical resection of lung cancer
      successfully and enjoyed a peaceful postoperative rehabilitation. OUTCOMES:
      Although pathological diagnosed confirmed early stage lung adenocarcinoma
      (T1N0M0). The patient had tumor recurrence 7 months after operation. Gene
      sequencing confirmed the G719S mutation in exon 18 of the EGFR gene and target
      therapy, chemotherapy and radiotherapy were all given to this patient
      successively, but they were all unresponsive. The patient died 26 months after
      surgery. LESSONS: We herein first report G719S mutation in lung adenocarcinoma
      with tonsillar metastasis. Generally, the tumor responded poorly to treatment and
      progressed quickly, which didn't achieve the desired effect. G719S mutant is
      supposed to be the cause of poor responsive to treatment.
FAU - Wu, Yimin
AU  - Wu Y
AD  - Department of Thoracic Surgery, the Second Affiliated Hospital, College of
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Zhu, Zhouyu
AU  - Zhu Z
FAU - Chen, Yongyuan
AU  - Chen Y
FAU - Chai, Ying
AU  - Chai Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/genetics/*pathology/therapy
MH  - China
MH  - Female
MH  - Genes, erbB-1/*genetics
MH  - Humans
MH  - Lung Neoplasms/genetics/*pathology/therapy
MH  - Middle Aged
MH  - Tonsillar Neoplasms/genetics/*secondary/therapy
PMC - PMC5728893
EDAT- 2017/12/17 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/12/17 06:00
PHST- 2017/12/17 06:00 [entrez]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
AID - 10.1097/MD.0000000000009003 [doi]
AID - 00005792-201712080-00067 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(49):e9003. doi: 10.1097/MD.0000000000009003.