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The therapeutic effect of modified Huangqi Guizhi Wuwu Tang for multiple myeloma: An 18-year follow-up case report.

Abstract Multiple myeloma (MM) is a hematologic malignancy characterized by proliferation of clonal plasma cells in the bone marrow. The median survival has increased to 6 years in recent years. But MM remains incurable. Some studies about the effects of Chinese herb medicine on MM have been carried out. Long survival in MM patients through Traditional Chinese Medicine (TCM) therapies has been reported rarely before.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29245321
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20180108
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 49
DP  - 2017 Dec
TI  - The therapeutic effect of modified Huangqi Guizhi Wuwu Tang for multiple myeloma:
      An 18-year follow-up case report.
PG  - e9074
LID - 10.1097/MD.0000000000009074 [doi]
AB  - RATIONALE: Multiple myeloma (MM) is a hematologic malignancy characterized by
      proliferation of clonal plasma cells in the bone marrow. The median survival has 
      increased to 6 years in recent years. But MM remains incurable. Some studies
      about the effects of Chinese herb medicine on MM have been carried out. Long
      survival in MM patients through Traditional Chinese Medicine (TCM) therapies has 
      been reported rarely before. PATIENT CONCERNS: We report a case of a female
      patient who was diagnosed with MM in 2000 at the age of 49. She received 9 cycles
      of multiple chemotherapeutic regimens mainly based on melphalan from September
      2000 to May 2001. Though her condition was under control in some degree, she
      discontinued treatment due to significant side effects such as fatigue,
      hyperhidrosis, fever, chill, larynx mucosa ulcers, pharynx mucosa ulcers, and
      poor appetite. Instead, she sought treatment with TCM alone. DIAGNOSES: Based on 
      the TCM theory, the patient's condition was categorized as Xue Bi. INTERVENTIONS:
      Up to the present, the patient has been using modified Huangqi Guizhi Wuwu Tang
      (HGWT) continuously for 18 years. In this prescription, Radix Astragali is an
      important herb. When the patient's condition worsened, its dosage was increased
      from 30 to 120g. Besides, she has been eating Radix Astragali porridge or
      drinking Radix Astragali tea for almost 18 years at the same time. OUTCOMES:
      Throughout the period, no obvious side effects have been observed and her health 
      condition remains stable. LESSONS: Polysaccharides isolated from Astragalus
      membranaceus (Radix Astragali) and Polyporus umbellatus could promote maturation 
      of dendritic cells. Polysaccharides and flavonoids isolated from Astragalus
      membranaceus could regulate bone marrow microenvironment by inhibiting secretion 
      of interleukin (IL)-6, IL-12 p40 and bidirectionally regulating the osteogenic
      capacity of osteoblasts. Besides, Rhizoma Atractylodis Macrocephalae, another
      important component of the prescription, has inhibitory effects on osteolytic
      bone lesions. This case suggests TCM treatment may have a positive therapeutic
      effect on MM. Modified HGWT, especially the Chinese herb medicine Radix Astragali
      could potentially be an alternative option for the treatment of MM. Both
      pharmacological studies and randomized clinical trials are needed in the future.
FAU - Tian, Mingmin
AU  - Tian M
AD  - aBasic Medicine CollegebInternational Jingfang Institute, Nanjing University of
      Chinese Medicine, Nanjing, Jiangsu Province, China.
FAU - Huang, Huang
AU  - Huang H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Drugs, Chinese Herbal)
RN  - 922OP8YUPF (Huang Qi)
SB  - AIM
SB  - IM
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Medicine, Chinese Traditional
MH  - Middle Aged
MH  - Multiple Myeloma/*drug therapy
PMC - PMC5728936
EDAT- 2017/12/17 06:00
MHDA- 2018/01/09 06:00
CRDT- 2017/12/17 06:00
PHST- 2017/12/17 06:00 [entrez]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
AID - 10.1097/MD.0000000000009074 [doi]
AID - 00005792-201712080-00110 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(49):e9074. doi: 10.1097/MD.0000000000009074.