PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

A rare case of methimazole-induced cholestatic jaundice in an elderly man of Asian ethnicity with hyperthyroidism: A case report.

Abstract Methimazole is an antithyroid drug that is widely used for the treatment of hyperthyroidism. As an inhibitor of the enzyme thyroperoxidase, methimazole is generally well-tolerated. However, there have been increasing reports of methimazole-induced liver damage, although this effect of methimazole has been limited by the absence of objective diagnosis of the liver condition or the inappropriate use of the Naranjo scale. We present the case of an elderly man with hyperthyroidism, gastritis, and epilepsy who developed liver damage after administration of multiple drugs.
PMID
Related Publications

Methimazole-induced cholestatic jaundice in a hyperthyroid patient.

Steroids for the treatment of methimazole-induced severe cholestatic jaundice in a 74-year-old woman with type 2 diabetes.

Methimazole-induced cholestatic liver injury, mimicking sclerosing cholangitis.

Methimazole-induced cholestatic hepatitis: two cases report and literature review.

Methimazole-induced cholestatic jaundice in an elderly hyperthyroid patient.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29245333
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20180105
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 49
DP  - 2017 Dec
TI  - A rare case of methimazole-induced cholestatic jaundice in an elderly man of
      Asian ethnicity with hyperthyroidism: A case report.
PG  - e9093
LID - 10.1097/MD.0000000000009093 [doi]
AB  - BACKGROUND: Methimazole is an antithyroid drug that is widely used for the
      treatment of hyperthyroidism. As an inhibitor of the enzyme thyroperoxidase,
      methimazole is generally well-tolerated. However, there have been increasing
      reports of methimazole-induced liver damage, although this effect of methimazole 
      has been limited by the absence of objective diagnosis of the liver condition or 
      the inappropriate use of the Naranjo scale. We present the case of an elderly man
      with hyperthyroidism, gastritis, and epilepsy who developed liver damage after
      administration of multiple drugs. KEY POINTS FROM THE CASE: Considering the low
      sensitivity of the Naranjo scale in detecting rare reactions associated with
      liver damage, we used the Roussel-Uclaf Causality Assessment Method scale, with a
      finding of cholestatic jaundice hepatitis induced by methimazole. The patient's
      liver enzyme levels improved after discontinuation of methimazole. MAIN LESSONS
      LEARNED: Our case underlines the possible hepatoxicity associated with the use of
      methimazole. A review of the literature confirmed a selective hepatoxicity risk
      in individuals of Asian ethnicity, which has not been identified in Caucasian or 
      Black populations. Physicians should be aware of the risk of hepatoxicity when
      prescribing oral methimazole to patients of Asian ethnicity.
FAU - Ji, Hongjian
AU  - Ji H
AD  - aDepartment of Pharmacy, Affiliated Yancheng Hospital of Southeast University
      Medical CollegebDepartment of Pharmacy, Sir Runrun Hospital, Nanjing Medical
      UniversitycDepartment of Hepatobiliary Surgery, Affiliated Yancheng Hospital of
      Southeast University Medical College, Jiangsu, China.
FAU - Yue, Feng
AU  - Yue F
FAU - Song, Jianxiang
AU  - Song J
FAU - Zhou, Xiaohua
AU  - Zhou X
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antithyroid Agents)
RN  - 554Z48XN5E (Methimazole)
SB  - AIM
SB  - IM
MH  - Aged
MH  - Antithyroid Agents/*adverse effects/therapeutic use
MH  - Asian Continental Ancestry Group
MH  - Chemical and Drug Induced Liver Injury/*etiology
MH  - Humans
MH  - Hyperthyroidism/drug therapy
MH  - Jaundice, Obstructive/*chemically induced
MH  - Liver Function Tests
MH  - Male
MH  - Methimazole/*adverse effects/therapeutic use
PMC - PMC5728948
EDAT- 2017/12/17 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/12/17 06:00
PHST- 2017/12/17 06:00 [entrez]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
AID - 10.1097/MD.0000000000009093 [doi]
AID - 00005792-201712080-00122 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(49):e9093. doi: 10.1097/MD.0000000000009093.