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Potential killer in the ICU-severe tuberculosis combined with hemophagocytic syndrome: A case series and literature review.

Abstract Hemophagocytic syndrome (HPS) is a life-threatening clinical syndrome that has various presentations, shows rapid progression and is associated with a high mortality. Clinical reports about pulmonary tuberculosis combined with respiratory failure accompanied by HPS are rare.HPS has no special clinical manifestations, and the main presentations include persistent fever, hepatosplenomegaly, hematocytopenia, and rash. In the Intensive Care Unit (ICU), the clinical manifestations of severe infection and secondary HPS overlap, thus there is often a delay in the diagnosis and treatment of HPS.HPS is not an independent disease but represents an excessive inflammatory response due to immune dysfunction induced by various causes such as infection and tumor.The 2 cases in this report show that tuberculosis-associated hemophagocytic syndrome is not easy to find, especially in ICU. There are few clinical reports of pulmonary tuberculosis combined with respiratory failure and HPS. Here, we describe 2 such clinical cases and review the relevant literature in order to deepen our understanding of this disease.
PMID
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Authors

Mayor MeshTerms

Intensive Care Units

Keywords
Journal Title medicine
Publication Year Start




PMID- 29245359
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20180105
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 49
DP  - 2017 Dec
TI  - Potential killer in the ICU-severe tuberculosis combined with hemophagocytic
      syndrome: A case series and literature review.
PG  - e9142
LID - 10.1097/MD.0000000000009142 [doi]
AB  - Hemophagocytic syndrome (HPS) is a life-threatening clinical syndrome that has
      various presentations, shows rapid progression and is associated with a high
      mortality. Clinical reports about pulmonary tuberculosis combined with
      respiratory failure accompanied by HPS are rare.HPS has no special clinical
      manifestations, and the main presentations include persistent fever,
      hepatosplenomegaly, hematocytopenia, and rash. In the Intensive Care Unit (ICU), 
      the clinical manifestations of severe infection and secondary HPS overlap, thus
      there is often a delay in the diagnosis and treatment of HPS.HPS is not an
      independent disease but represents an excessive inflammatory response due to
      immune dysfunction induced by various causes such as infection and tumor.The 2
      cases in this report show that tuberculosis-associated hemophagocytic syndrome is
      not easy to find, especially in ICU. There are few clinical reports of pulmonary 
      tuberculosis combined with respiratory failure and HPS. Here, we describe 2 such 
      clinical cases and review the relevant literature in order to deepen our
      understanding of this disease.
FAU - Chen, Lulu
AU  - Chen L
AD  - Department of Respiratory Diseases, Fuzhou Pulmonary Hospital of Fujian, Fuzhou, 
      China.
FAU - Weng, Heng
AU  - Weng H
FAU - Li, Hongyan
AU  - Li H
FAU - Huang, Jinbao
AU  - Huang J
FAU - Pan, Jianguang
AU  - Pan J
FAU - Huang, Yansheng
AU  - Huang Y
FAU - Ma, Chenhui
AU  - Ma C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antitubercular Agents)
SB  - AIM
SB  - IM
MH  - Antitubercular Agents/therapeutic use
MH  - Humans
MH  - *Intensive Care Units
MH  - Lymphohistiocytosis, Hemophagocytic/*complications
MH  - Male
MH  - Middle Aged
MH  - Tuberculosis, Pulmonary/*complications/drug therapy
MH  - Young Adult
PMC - PMC5728974
EDAT- 2017/12/17 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/12/17 06:00
PHST- 2017/12/17 06:00 [entrez]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
AID - 10.1097/MD.0000000000009142 [doi]
AID - 00005792-201712080-00148 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(49):e9142. doi: 10.1097/MD.0000000000009142.