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PMID- 29245363
DCOM- 20180105
LR  - 20180105
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 49
DP  - 2017 Dec
TI  - Nasopharyngeal carcinoma with central nervous system metastases: Two case reports
      and a review of the literature.
PG  - e9175
LID - 10.1097/MD.0000000000009175 [doi]
AB  - RATIONALE: Central nervous system (CNS) metastases are rarely seen in patients
      with nasopharyngeal carcinoma (NPC). PATIENT CONCERNS: Two NPC patients developed
      CNS metastases were collected in Fudan University Shanghai Cancer Center. The
      medical records were reviewed to document patients' characteristics, treatment,
      and outcomes. In addition, we also provide an overview of the literature
      concerning this scenario. DIAGNOSES: Both patients were staged T4N1M0 with
      pathologically confirmed CNS metastases from nasopharyngeal carcinoma.
      INTERVENTIONS: After the completion of initial chemoradiotherapy, metastases to
      CNS including brain and/or spine occurred during follow-up. Surgical resection
      combined with palliative chemoradiation was offered to alleviate the symptoms.
      OUTCOMES: Although multiple treatment modalities were given, both patients
      succumbed to disease progression. LESSONS: The mechanism for CNS metastases is
      postulated through hematogenous route or cerebral spinal fluid spread. Good
      symptoms amelioration can be achieved with aggressive treatments such as surgery 
      followed by palliative chemoradiation, but prognoses are ominous due to
      systematic disease dissemination.
FAU - Shen, Chunying
AU  - Shen C
AD  - aDepartment of Radiation Oncology, Fudan University Shanghai Cancer
      CenterbDepartment of Oncology, Shanghai Medical College, Fudan University,
      Shanghai, China.
FAU - Ying, Hongmei
AU  - Ying H
FAU - Lu, Xueguan
AU  - Lu X
FAU - Hu, Chaosu
AU  - Hu C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - Nasopharyngeal carcinoma
SB  - IM
MH  - Carcinoma/*pathology/therapy
MH  - Central Nervous System Neoplasms/*secondary/therapy
MH  - China
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/*pathology/therapy
PMC - PMC5728978
EDAT- 2017/12/17 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/12/17 06:00
PHST- 2017/12/17 06:00 [entrez]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
AID - 10.1097/MD.0000000000009175 [doi]
AID - 00005792-201712080-00152 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(49):e9175. doi: 10.1097/MD.0000000000009175.