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PMID- 29245365
DCOM- 20180105
LR  - 20180105
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 49
DP  - 2017 Dec
TI  - Teratoma-associated anti-NMDAR encephalitis: Two cases report and literature
PG  - e9177
LID - 10.1097/MD.0000000000009177 [doi]
AB  - OBJECTIVE: This study aimed to discuss the pathogenesis, clinical manifestation, 
      diagnosis, and treatment of anti-N-methyl-D-aspartate receptor (NMDAR)
      encephalitis. CASE REPORT: The diagnosis and treatment of 2 cases with
      teratoma-associated anti-NMDAR encephalitis were summarized and the clinical data
      of patients reported by domestic and international studies were reviewed in this 
      study. The 2 cases were both adolescent females who showed mental abnormalities
      as their main clinical manifestation. The patients were positive for anti-NMDAR
      antibody in their serum and cerebrospinal fluid, and gynecologic ultrasound
      detected ovarian teratoma. After diagnosis, the patients underwent teratoma
      resection, followed by pulse therapy of hormones and gamma globulin. Chemotherapy
      was performed to prevent tumor recurrence, and patients were in a stable
      condition. CONCLUSIONS: Teratoma-associated anti-NMDAR encephalitis is commonly
      seen in young women. The clinical manifestation of this disease is nonspecific,
      and the patients mainly have fever, psychosis, and seizure. Tumor resection and
      immune therapy are effective treatment strategies, and standardized chemotherapy 
      should also be performed to prevent recurrence.
FAU - Liang, Zhigang
AU  - Liang Z
AD  - aDepartment of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao
      University, Yantai, ShandongbDepartment of Neurology, Beijing Tiantan Hospital,
      Beijing, P. R. China.
FAU - Yang, Shaowan
AU  - Yang S
FAU - Sun, Xuwen
AU  - Sun X
FAU - Li, Bing
AU  - Li B
FAU - Li, Wei
AU  - Li W
FAU - Liu, Zhuli
AU  - Liu Z
FAU - Yu, Guoping
AU  - Yu G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Autoantibodies)
RN  - Teratoma, Ovarian
SB  - IM
MH  - Adolescent
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*etiology/*physiopathology
MH  - Autoantibodies/blood
MH  - Female
MH  - Humans
MH  - Ovarian Neoplasms/*complications/therapy
MH  - Teratoma/*complications/therapy
PMC - PMC5728980
EDAT- 2017/12/17 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/12/17 06:00
PHST- 2017/12/17 06:00 [entrez]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
AID - 10.1097/MD.0000000000009177 [doi]
AID - 00005792-201712080-00154 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(49):e9177. doi: 10.1097/MD.0000000000009177.