PubTransformer

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PMID- 29246336
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20171226
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Linking)
VI  - 192
DP  - 2018 Jan
TI  - Hearing Loss after Cardiac Surgery in Infancy: An Unintended Consequence of
      Life-Saving Care.
PG  - 144-151.e1
LID - S0022-3476(17)31303-3 [pii]
LID - 10.1016/j.jpeds.2017.09.049 [doi]
AB  - OBJECTIVES: To investigate the prevalence of hearing loss after cardiac surgery
      in infancy, patient and operative factors associated with hearing loss, and the
      relationship of hearing loss to neurodevelopmental outcomes. STUDY DESIGN:
      Audiologic and neurodevelopmental evaluations were conducted on 348 children who 
      underwent repair of congenital heart disease at the Children's Hospital of
      Philadelphia as part of a prospective study evaluating neurodevelopmental
      outcomes at 4 years of age. A prevalence estimate was calculated based on
      presence and type of hearing loss. Potential risk factors and the impact of
      hearing loss on neurodevelopmental outcomes were evaluated. RESULTS: The
      prevalence of hearing loss was 21.6% (95% CI, 17.2-25.9). The prevalence of
      conductive hearing loss, sensorineural hearing loss, and indeterminate hearing
      loss were 12.4% (95% CI, 8.8-16.0), 6.9% (95% CI, 4.1-9.7), and 2.3% (95% CI,
      0.6-4.0), respectively. Only 18 of 348 subjects (5.2%) had screened positive for 
      hearing loss before this study and 10 used a hearing aid. After adjusting for
      patient and operative covariates, younger gestational age, longer postoperative
      duration of stay, and a confirmed genetic anomaly were associated with hearing
      loss (all P < .01). The presence of hearing loss was associated with worse
      language, cognition and attention (P <.01). CONCLUSIONS: These findings suggest
      that the prevalence of hearing loss in preschool children after heart surgery in 
      infancy may be 20-fold higher than in the 1% prevalence seen in the general
      population. Younger gestational age, presence of a genetic anomaly, and longer
      postoperative duration of stay were associated with hearing loss. Hearing loss
      was associated with worse neurodevelopmental outcomes.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Grasty, Madison A
AU  - Grasty MA
AD  - Division of Cardiothoracic Surgery, Children's Hospital of Philadelphia,
      Philadelphia, PA.
FAU - Ittenbach, Richard F
AU  - Ittenbach RF
AD  - Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital
      Medical Center, Cincinnati, OH.
FAU - Knightly, Carol
AU  - Knightly C
AD  - Center for Childhood Communication, Children's Hospital of Philadelphia,
      Philadelphia, PA.
FAU - Solot, Cynthia B
AU  - Solot CB
AD  - Center for Childhood Communication, Children's Hospital of Philadelphia,
      Philadelphia, PA.
FAU - Gerdes, Marsha
AU  - Gerdes M
AD  - Psychology, Children's Hospital of Philadelphia, Philadelphia, PA.
FAU - Bernbaum, Judy C
AU  - Bernbaum JC
AD  - Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
FAU - Wernovsky, Gil
AU  - Wernovsky G
AD  - Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA; Department of 
      Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia,
      Philadelphia, PA.
FAU - Spray, Thomas L
AU  - Spray TL
AD  - Division of Cardiothoracic Surgery, Children's Hospital of Philadelphia,
      Philadelphia, PA.
FAU - Nicolson, Susan C
AU  - Nicolson SC
AD  - Department of Anesthesia and Critical Care Medicine, Children's Hospital of
      Philadelphia, Philadelphia, PA.
FAU - Clancy, Robert R
AU  - Clancy RR
AD  - Department of Pediatrics, Division of Neurology, Children's Hospital of
      Philadelphia, Philadelphia, PA.
FAU - Licht, Daniel J
AU  - Licht DJ
AD  - Department of Pediatrics, Division of Neurology, Children's Hospital of
      Philadelphia, Philadelphia, PA.
FAU - Zackai, Elaine
AU  - Zackai E
AD  - Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; Genetics,
      Children's Hospital of Philadelphia, Philadelphia, PA.
FAU - Gaynor, J William
AU  - Gaynor JW
AD  - Division of Cardiothoracic Surgery, Children's Hospital of Philadelphia,
      Philadelphia, PA.
FAU - Burnham, Nancy B
AU  - Burnham NB
AD  - Division of Cardiothoracic Surgery, Children's Hospital of Philadelphia,
      Philadelphia, PA. Electronic address: [email protected]
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
SB  - AIM
SB  - IM
MH  - Child Development
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Hearing Loss/diagnosis/epidemiology/*etiology
MH  - Heart Defects, Congenital/*surgery
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Postoperative Complications/diagnosis/epidemiology/*etiology
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - attention
OT  - cognition
OT  - language
OT  - neurodevelopmental
OT  - prevalence
OT  - sensorineural
EDAT- 2017/12/17 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/12/17 06:00
PHST- 2017/04/14 00:00 [received]
PHST- 2017/08/30 00:00 [revised]
PHST- 2017/09/20 00:00 [accepted]
PHST- 2017/12/17 06:00 [entrez]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - S0022-3476(17)31303-3 [pii]
AID - 10.1016/j.jpeds.2017.09.049 [doi]
PST - ppublish
SO  - J Pediatr. 2018 Jan;192:144-151.e1. doi: 10.1016/j.jpeds.2017.09.049.