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PMID- 29246341
DCOM- 20171226
LR  - 20171226
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Linking)
VI  - 192
DP  - 2018 Jan
TI  - Comorbidity of Type 1 Diabetes Mellitus in Patients with Juvenile Idiopathic
PG  - 196-203
LID - S0022-3476(17)31053-3 [pii]
LID - 10.1016/j.jpeds.2017.07.050 [doi]
AB  - OBJECTIVES: To determine the prevalence of type 1 diabetes mellitus (T1D) in
      patients with juvenile idiopathic arthritis (JIA) and to characterize patients
      having both. STUDY DESIGN: Diabetes comorbidity was recorded in the National
      Pediatric Rheumatologic Database since 2012. Data from the North
      Rhine-Westphalian diabetes registry served as the reference population for the
      prevalence of diabetes in the general population. The National Pediatric
      Rheumatologic Database data were indirectly standardized for age and sex for
      comparison with the general population. The diabetes prevalence ratio was
      calculated using the Poisson regression model. RESULTS: The analysis included 12 
      269 patients with JIA. A total of 58 patients had comorbid T1D, and the diabetes 
      prevalence was 0.5%. The mean age was 11.6 years at the time of documentation,
      and the mean disease duration was 4.2 years. Compared with the general
      population, the prevalence of diabetes in patients with JIA was significantly
      increased (prevalence ratio 1.76 [95% CI 1.34; 2.28], P < .001). The onset of
      diabetes in patients with JIA was earlier than that reported in the reference
      data. Sixty-three percent of patients developed T1D before JIA. On average,
      diabetes onset was 56 months before the onset of JIA. Patients who first
      developed JIA developed T1D on average 40 months later. The majority of patients 
      had not received disease-modifying antirheumatic drugs before diabetes onset.
      CONCLUSIONS: T1D occurs more frequently in patients with JIA than in the general 
      population. The likelihood of T1D occurrence appears to be slightly higher before
      JIA manifestation and without disease-modifying antirheumatic drug therapy after 
      JIA onset.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Schenck, Sandra
AU  - Schenck S
AD  - German Rheumatism Research Center Berlin, a Leibniz Institute, Berlin, Berlin,
      Germany. Electronic address: [email protected]
FAU - Rosenbauer, Joachim
AU  - Rosenbauer J
AD  - Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Centre
      at Heinrich-Heine University Dusseldorf, Dusseldorf, Germany; German Center for
      Diabetes Research (DZD), Munich-Neuherberg, Germany.
FAU - Niewerth, Martina
AU  - Niewerth M
AD  - German Rheumatism Research Center Berlin, a Leibniz Institute, Berlin, Berlin,
FAU - Klotsche, Jens
AU  - Klotsche J
AD  - German Rheumatism Research Center Berlin, a Leibniz Institute, Berlin, Berlin,
      Germany; Institute for Social Medicine, Epidemiology and Health Economics,
      Charite Universitatsmedizin, Berlin, Germany.
FAU - Minden, Kirsten
AU  - Minden K
AD  - German Rheumatism Research Center Berlin, a Leibniz Institute, Berlin, Berlin,
      Germany; Department of Rheumatology and Clinical Immunology, Charite
      Universitatsmedizin Berlin, Berlin, Germany.
FAU - Schwarz, Tobias
AU  - Schwarz T
AD  - Department of Pediatric Rheumatology, St. Josef-Stift, Sendenhorst, Germany.
FAU - Foeldvari, Ivan
AU  - Foeldvari I
AD  - Hamburg Centre for Rheumatology for Children and Adolescents, Clinical Center
      Eilbek, Germany.
FAU - Horneff, Gerd
AU  - Horneff G
AD  - Asklepios Clinic Sankt Augustin, Sankt Augustin, University Hospital of Cologne, 
      Cologne, Germany.
FAU - Weller-Heinemann, Frank
AU  - Weller-Heinemann F
AD  - Department of Pediatric Rheumatology, Prof.-Hess-Kinderklinik, Bremen, Germany.
FAU - Holl, Reinhard W
AU  - Holl RW
AD  - Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm,
FAU - Thon, Angelika
AU  - Thon A
AD  - Department of Pediatric Pneumology, Allergology and Neonatology, Children's
      Hospital, Medical School, Hanover, Germany.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Arthritis, Juvenile/*epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Databases, Factual
MH  - Diabetes Mellitus, Type 1/*epidemiology
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Male
MH  - Poisson Distribution
MH  - Prevalence
MH  - Registries
MH  - Regression Analysis
OT  - autoimmune diseases
OT  - observational study
OT  - type 1 diabetes mellitus prevalence
EDAT- 2017/12/17 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/12/17 06:00
PHST- 2017/04/26 00:00 [received]
PHST- 2017/06/02 00:00 [revised]
PHST- 2017/07/26 00:00 [accepted]
PHST- 2017/12/17 06:00 [entrez]
PHST- 2017/12/17 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - S0022-3476(17)31053-3 [pii]
AID - 10.1016/j.jpeds.2017.07.050 [doi]
PST - ppublish
SO  - J Pediatr. 2018 Jan;192:196-203. doi: 10.1016/j.jpeds.2017.07.050.