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Genetic and antigenic divergence in the influenza A(H3N2) virus circulating between 2016 and 2017 in Thailand.

Abstract Influenza virus evolves rapidly due to the accumulated genetic variations on the viral sequence. Unlike in North America and Europe, influenza season in the tropical Southeast Asia spans both the rainy and cool seasons. Thus, influenza epidemiology and viral evolution sometimes differ from other regions, which affect the ever-changing efficacy of the vaccine. To monitor the current circulating influenza viruses in this region, we determined the predominant influenza virus strains circulating in Thailand between January 2016 and June 2017 by screening 7,228 samples from patients with influenza-like illness. During this time, influenza A(H3N2) virus was the predominant influenza virus detected. We then phylogenetically compared the hemagglutinin (HA) gene from a subset of these A(H3N2) strains (n = 62) to the reference sequences and evaluated amino acid changes in the dominant antigenic epitopes on the HA protein structure. The divergence of the circulating A(H3N2) from the A/Hong Kong/4801/2014 vaccine strain formed five genetic groups (designated I to V) within the 3C.2a clade. Our results suggest a marked drift of the current circulating A(H3N2) strains in Thailand, which collectively contributed to the declining predicted vaccine effectiveness (VE) from 74% in 2016 down to 48% in 2017.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos one
Publication Year Start




PMID- 29252990
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20180108
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 12
DP  - 2017
TI  - Genetic and antigenic divergence in the influenza A(H3N2) virus circulating
      between 2016 and 2017 in Thailand.
PG  - e0189511
LID - 10.1371/journal.pone.0189511 [doi]
AB  - Influenza virus evolves rapidly due to the accumulated genetic variations on the 
      viral sequence. Unlike in North America and Europe, influenza season in the
      tropical Southeast Asia spans both the rainy and cool seasons. Thus, influenza
      epidemiology and viral evolution sometimes differ from other regions, which
      affect the ever-changing efficacy of the vaccine. To monitor the current
      circulating influenza viruses in this region, we determined the predominant
      influenza virus strains circulating in Thailand between January 2016 and June
      2017 by screening 7,228 samples from patients with influenza-like illness. During
      this time, influenza A(H3N2) virus was the predominant influenza virus detected. 
      We then phylogenetically compared the hemagglutinin (HA) gene from a subset of
      these A(H3N2) strains (n = 62) to the reference sequences and evaluated amino
      acid changes in the dominant antigenic epitopes on the HA protein structure. The 
      divergence of the circulating A(H3N2) from the A/Hong Kong/4801/2014 vaccine
      strain formed five genetic groups (designated I to V) within the 3C.2a clade. Our
      results suggest a marked drift of the current circulating A(H3N2) strains in
      Thailand, which collectively contributed to the declining predicted vaccine
      effectiveness (VE) from 74% in 2016 down to 48% in 2017.
FAU - Suntronwong, Nungruthai
AU  - Suntronwong N
AD  - Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of
      Medicine, Chulalongkorn University, Bangkok, Thailand.
FAU - Klinfueng, Sirapa
AU  - Klinfueng S
AD  - Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of
      Medicine, Chulalongkorn University, Bangkok, Thailand.
FAU - Vichiwattana, Preeyaporn
AU  - Vichiwattana P
AD  - Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of
      Medicine, Chulalongkorn University, Bangkok, Thailand.
FAU - Korkong, Sumeth
AU  - Korkong S
AD  - Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of
      Medicine, Chulalongkorn University, Bangkok, Thailand.
FAU - Thongmee, Thanunrat
AU  - Thongmee T
AD  - Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of
      Medicine, Chulalongkorn University, Bangkok, Thailand.
FAU - Vongpunsawad, Sompong
AU  - Vongpunsawad S
AD  - Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of
      Medicine, Chulalongkorn University, Bangkok, Thailand.
FAU - Poovorawan, Yong
AU  - Poovorawan Y
AUID- ORCID: http://orcid.org/0000-0002-2337-6807
AD  - Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of
      Medicine, Chulalongkorn University, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20171218
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Amino Acids)
RN  - 0 (Epitopes)
RN  - 0 (Hemagglutinin Glycoproteins, Influenza Virus)
RN  - 0 (Influenza Vaccines)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Amino Acids/chemistry
MH  - Epitopes/immunology
MH  - Genetic Variation
MH  - Hemagglutinin Glycoproteins, Influenza Virus/genetics/*immunology
MH  - Humans
MH  - Influenza A Virus, H3N2 Subtype/*genetics/*immunology
MH  - Influenza Vaccines/*immunology
MH  - Influenza, Human/*epidemiology/*immunology
MH  - Phylogeny
MH  - RNA, Viral/genetics
MH  - Seasons
MH  - Thailand/epidemiology
PMC - PMC5734729
EDAT- 2017/12/19 06:00
MHDA- 2018/01/09 06:00
CRDT- 2017/12/19 06:00
PHST- 2017/09/14 00:00 [received]
PHST- 2017/11/28 00:00 [accepted]
PHST- 2017/12/19 06:00 [entrez]
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
AID - 10.1371/journal.pone.0189511 [doi]
AID - PONE-D-17-33537 [pii]
PST - epublish
SO  - PLoS One. 2017 Dec 18;12(12):e0189511. doi: 10.1371/journal.pone.0189511.
      eCollection 2017.