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Comparisons of auditory brainstem response and sound level tolerance in tinnitus ears and non-tinnitus ears in unilateral tinnitus patients with normal audiograms.

Abstract Recently, "hidden hearing loss" with cochlear synaptopathy has been suggested as a potential pathophysiology of tinnitus in individuals with a normal hearing threshold. Several studies have demonstrated that subjects with tinnitus and normal audiograms show significantly reduced auditory brainstem response (ABR) wave I amplitudes compared with control subjects, but normal wave V amplitudes, suggesting increased central auditory gain. We aimed to reconfirm the "hidden hearing loss" theory through a within-subject comparison of wave I and wave V amplitudes and uncomfortable loudness level (UCL), which might be decreased with increased central gain, in tinnitus ears (TEs) and non-tinnitus ears (NTEs).
PMID
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Authors

Mayor MeshTerms

Audiometry, Pure-Tone

Sound

Keywords
Journal Title plos one
Publication Year Start




PMID- 29253030
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20180108
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 12
DP  - 2017
TI  - Comparisons of auditory brainstem response and sound level tolerance in tinnitus 
      ears and non-tinnitus ears in unilateral tinnitus patients with normal
      audiograms.
PG  - e0189157
LID - 10.1371/journal.pone.0189157 [doi]
AB  - OBJECTIVE: Recently, "hidden hearing loss" with cochlear synaptopathy has been
      suggested as a potential pathophysiology of tinnitus in individuals with a normal
      hearing threshold. Several studies have demonstrated that subjects with tinnitus 
      and normal audiograms show significantly reduced auditory brainstem response
      (ABR) wave I amplitudes compared with control subjects, but normal wave V
      amplitudes, suggesting increased central auditory gain. We aimed to reconfirm the
      "hidden hearing loss" theory through a within-subject comparison of wave I and
      wave V amplitudes and uncomfortable loudness level (UCL), which might be
      decreased with increased central gain, in tinnitus ears (TEs) and non-tinnitus
      ears (NTEs). SUBJECTS AND METHODS: Human subjects included 43 unilateral tinnitus
      patients (19 males, 24 females) with normal and symmetric hearing thresholds and 
      18 control subjects with normal audiograms. The amplitudes of wave I and V from
      the peak to the following trough were measured twice at 90 dB nHL and we
      separately assessed UCLs at 500 Hz and 3000 Hz pure tones in each TE and NTE.
      RESULTS: The within-subject comparison between TEs and NTEs showed no significant
      differences in wave I and wave V amplitude, or wave V/I ratio in both the male
      and female groups. Individual data revealed increased V/I amplitude ratios > mean
      + 2 SD in 3 TEs, but not in any control ears. We found no significant differences
      in UCL at 500 Hz or 3000 Hz between the TEs and NTEs, but the UCLs of both TEs
      and NTEs were lower than those of the control ears. CONCLUSIONS: Our ABR data do 
      not represent meaningful evidence supporting the hypothesis of cochlear
      synaptopathy with increased central gain in tinnitus subjects with normal
      audiograms. However, reduced sound level tolerance in both TEs and NTEs might
      reflect increased central gain consequent on hidden synaptopathy that was
      subsequently balanced between the ears by lateral olivocochlear efferents.
FAU - Shim, Hyun Joon
AU  - Shim HJ
AUID- ORCID: http://orcid.org/0000-0001-9719-6959
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Eulji University School 
      of Medicine, Eulji Medical Center, Seoul, Korea.
FAU - An, Yong-Hwi
AU  - An YH
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Eulji University School 
      of Medicine, Eulji Medical Center, Seoul, Korea.
FAU - Kim, Dong Hyun
AU  - Kim DH
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Eulji University School 
      of Medicine, Eulji Medical Center, Seoul, Korea.
FAU - Yoon, Ji Eun
AU  - Yoon JE
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Eulji University School 
      of Medicine, Eulji Medical Center, Seoul, Korea.
FAU - Yoon, Ji Hyang
AU  - Yoon JH
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Eulji University School 
      of Medicine, Eulji Medical Center, Seoul, Korea.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20171218
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - *Audiometry, Pure-Tone
MH  - Auditory Threshold/*physiology
MH  - Case-Control Studies
MH  - Ear/physiopathology
MH  - Evoked Potentials, Auditory, Brain Stem/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Sound
MH  - Tinnitus/*physiopathology
PMC - PMC5734686
EDAT- 2017/12/19 06:00
MHDA- 2018/01/09 06:00
CRDT- 2017/12/19 06:00
PHST- 2017/08/10 00:00 [received]
PHST- 2017/11/20 00:00 [accepted]
PHST- 2017/12/19 06:00 [entrez]
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
AID - 10.1371/journal.pone.0189157 [doi]
AID - PONE-D-17-29601 [pii]
PST - epublish
SO  - PLoS One. 2017 Dec 18;12(12):e0189157. doi: 10.1371/journal.pone.0189157.
      eCollection 2017.