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The interruption of Onchocerca volvulus and Wuchereria bancrofti transmission by integrated chemotherapy in the Obongi focus, North Western Uganda.

Abstract Few studies have documented the interruption of onchocerciasis and Lymphatic Filariasis (LF) by integrated chemotherapy in Uganda. The study describes the interruption of transmission of the two diseases co-endemic in Obongi focus, north western Uganda. Base line data for Onchocerciasis and LF were collected in 1994 and 2006, respectively. Annual mass drug administration for onchocerciasis (Ivermectin) and Lymphatic Filariasis (Ivermectin + albendazole) was conducted for 20 and 6 years, respectively. Thereafter, assessments by skin snip, larval searches in rivers and human landing catches were performed. Children <10 years were screened for IgG4 antibodies using Ov16 ELISA technique in 2013. LF Pre-TAS and TAS1 were conducted in sentinel sites. ITN coverage and utilization for the implementation unit was also reported.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos one
Publication Year Start




PMID- 29253862
OWN - NLM
STAT- In-Process
LR  - 20171218
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 12
DP  - 2017
TI  - The interruption of Onchocerca volvulus and Wuchereria bancrofti transmission by 
      integrated chemotherapy in the Obongi focus, North Western Uganda.
PG  - e0189306
LID - 10.1371/journal.pone.0189306 [doi]
AB  - INTERVENTION: Few studies have documented the interruption of onchocerciasis and 
      Lymphatic Filariasis (LF) by integrated chemotherapy in Uganda. The study
      describes the interruption of transmission of the two diseases co-endemic in
      Obongi focus, north western Uganda. Base line data for Onchocerciasis and LF were
      collected in 1994 and 2006, respectively. Annual mass drug administration for
      onchocerciasis (Ivermectin) and Lymphatic Filariasis (Ivermectin + albendazole)
      was conducted for 20 and 6 years, respectively. Thereafter, assessments by skin
      snip, larval searches in rivers and human landing catches were performed.
      Children &lt;10 years were screened for IgG4 antibodies using Ov16 ELISA technique
      in 2013. LF Pre-TAS and TAS1 were conducted in sentinel sites. ITN coverage and
      utilization for the implementation unit was also reported. INTERVENTION COVERAGE:
      Onchocerciasis treatment coverage was &lt;80% but improved with the introduction of 
      CDTI in 1999. While for LF, effective coverage of &gt;65% was achieved in the six
      treatment rounds. Household ownership of ITN's and utilization was 96% and
      72.4%., respectively. IMPACT: Parasitological examinations conducted for
      onchocerciasis among 807 adults and children, revealed a reduction in mf
      prevalence from 58% in 1994 to 0% in 2012. Entomological monitoring conducted at 
      the two sites had no single Simulium damnosum fly caught. Serological analysis
      using Ov16 ELISA for onchocerciasis revealed that out of the 3,308 children &lt;10
      years old screened in 2013, only 3/3308 (0.091%) positive cases were detected.
      All Ov16 positive children were negative when tested for patent infection by skin
      snip PCR. A reduction in LF microfilaria prevalence from 2.5% (n = 13/522) in
      2006 to 0.0% (n = 602) in 2014 was observed. LF TAS1 conducted in 2015 among
      1,532 children 6-7 years, all were negative for antigens of W. bancrofti.
      CONCLUSION: The results concluded that interruption of onchocerciasis and LF has 
      been achieved.
FAU - Luroni, Lakwo Thomson
AU  - Luroni LT
AUID- ORCID: http://orcid.org/0000-0002-7081-5323
AD  - Vector Control Division, Ministry of Health, Kampala, Uganda.
FAU - Gabriel, Matwale
AU  - Gabriel M
AD  - Vector Control Division, Ministry of Health, Kampala, Uganda.
FAU - Tukahebwa, Edridah
AU  - Tukahebwa E
AD  - Vector Control Division, Ministry of Health, Kampala, Uganda.
FAU - Onapa, Ambrose Winston
AU  - Onapa AW
AD  - Envision/RTI- Neglected Tropical Diseases Control Programme, Kampala, Uganda.
FAU - Tinkitina, Benjamin
AU  - Tinkitina B
AD  - Vector Control Division, Ministry of Health, Kampala, Uganda.
FAU - Tukesiga, Ephraim
AU  - Tukesiga E
AD  - Kabarole District Local Government, Fort Portal, Uganda.
FAU - Nyaraga, Michael
AU  - Nyaraga M
AD  - Moyo District Local Government, Medical Department, Moyo, Uganda.
FAU - Auma, Anna Mary
AU  - Auma AM
AD  - Vector Control Division, Ministry of Health, Kampala, Uganda.
FAU - Habomugisha, Peace
AU  - Habomugisha P
AD  - The Carter Center, Uganda office, Kampala, Uganda.
FAU - Byamukama, Edson
AU  - Byamukama E
AD  - The Carter Center, Uganda office, Kampala, Uganda.
FAU - Oguttu, David
AU  - Oguttu D
AD  - Vector Control Division, Ministry of Health, Kampala, Uganda.
FAU - Katabarwa, Moses
AU  - Katabarwa M
AD  - The Carter Center, Atlanta, United States of America.
FAU - Unnasch, Thomas Raymond
AU  - Unnasch TR
AD  - University of South Florida, Global Health Infectious Disease Research, College
      of Public Health, Tampa, FL, United States of America.
LA  - eng
PT  - Journal Article
DEP - 20171218
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
EDAT- 2017/12/19 06:00
MHDA- 2017/12/19 06:00
CRDT- 2017/12/19 06:00
PHST- 2017/05/25 00:00 [received]
PHST- 2017/11/22 00:00 [accepted]
PHST- 2017/12/19 06:00 [entrez]
PHST- 2017/12/19 06:00 [pubmed]
PHST- 2017/12/19 06:00 [medline]
AID - 10.1371/journal.pone.0189306 [doi]
AID - PONE-D-17-20126 [pii]
PST - epublish
SO  - PLoS One. 2017 Dec 18;12(12):e0189306. doi: 10.1371/journal.pone.0189306.
      eCollection 2017.