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Chromosomal abnormalities in 163 Tunisian couples with recurrent miscarriages.

Abstract Recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses before 24 weeks of gestation. Parental chromosomal abnormalities represent an important etiology of RM. The aim of the present study was to identify the distribution of chromosome abnormalities among Tunisian couples with RM referred to the Department of Cytogenetic at the Pasteur Institute of Tunis (Tunisia) during the last five years. Standard cytogenetic analysis was carried out in a total of 163 couples presenting with two or more spontaneous abortions. Karyotypes were analyzed by R-banding. We identified 14 chromosomal abnormalities including autosomal reciprocal translocation, Robertsonian translocation, inversion, mosaic aneuploidy and heteromorphysm. The overall prevalence of chromosomal abnormalities was 8.5% in our cohort. This finding underlies the importance of cytogenetic investigations in the routine management of RM.
PMID
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Authors

Mayor MeshTerms

Chromosome Aberrations

Keywords

Recurrent miscarriage

chromosomal abnormalities

karyotype

Journal Title the pan african medical journal
Publication Year Start




PMID- 29255569
OWN - NLM
STAT- MEDLINE
DCOM- 20171222
LR  - 20171222
IS  - 1937-8688 (Electronic)
VI  - 28
DP  - 2017
TI  - Chromosomal abnormalities in 163 Tunisian couples with recurrent miscarriages.
PG  - 99
LID - 10.11604/pamj.2017.28.99.11879 [doi]
AB  - Recurrent miscarriage (RM) is defined as three or more consecutive pregnancy
      losses before 24 weeks of gestation. Parental chromosomal abnormalities represent
      an important etiology of RM. The aim of the present study was to identify the
      distribution of chromosome abnormalities among Tunisian couples with RM referred 
      to the Department of Cytogenetic at the Pasteur Institute of Tunis (Tunisia)
      during the last five years. Standard cytogenetic analysis was carried out in a
      total of 163 couples presenting with two or more spontaneous abortions.
      Karyotypes were analyzed by R-banding. We identified 14 chromosomal abnormalities
      including autosomal reciprocal translocation, Robertsonian translocation,
      inversion, mosaic aneuploidy and heteromorphysm. The overall prevalence of
      chromosomal abnormalities was 8.5% in our cohort. This finding underlies the
      importance of cytogenetic investigations in the routine management of RM.
FAU - Ayed, Wiem
AU  - Ayed W
AD  - Department of Histology and Cytogenetics, Institut Pasteur de Tunis, Tunisie.
AD  - Faculty of Medecine of Tunis, University of Tunis El Manar, Tunisia.
AD  - Laboratory of Biomedical Genomics and Onco-genetics LR11IPT05, Institut Pasteur
      de Tunis, Tunisia.
FAU - Messaoudi, Islem
AU  - Messaoudi I
AD  - Department of Histology and Cytogenetics, Institut Pasteur de Tunis, Tunisie.
FAU - Belghith, Zouhour
AU  - Belghith Z
AD  - Department of Histology and Cytogenetics, Institut Pasteur de Tunis, Tunisie.
FAU - Hammami, Wajih
AU  - Hammami W
AD  - Department of Histology and Cytogenetics, Institut Pasteur de Tunis, Tunisie.
AD  - Laboratory of Biomedical Genomics and Onco-genetics LR11IPT05, Institut Pasteur
      de Tunis, Tunisia.
FAU - Chemkhi, Imen
AU  - Chemkhi I
AD  - Department of Histology and Cytogenetics, Institut Pasteur de Tunis, Tunisie.
FAU - Abidli, Nabila
AU  - Abidli N
AD  - Department of Histology and Cytogenetics, Institut Pasteur de Tunis, Tunisie.
FAU - Guermani, Helmy
AU  - Guermani H
AD  - Department of Histology and Cytogenetics, Institut Pasteur de Tunis, Tunisie.
FAU - Obay, Rim
AU  - Obay R
AD  - Department of Histology and Cytogenetics, Institut Pasteur de Tunis, Tunisie.
FAU - Amouri, Ahlem
AU  - Amouri A
AD  - Department of Histology and Cytogenetics, Institut Pasteur de Tunis, Tunisie.
AD  - Faculty of Medecine of Tunis, University of Tunis El Manar, Tunisia.
AD  - Laboratory of Biomedical Genomics and Onco-genetics LR11IPT05, Institut Pasteur
      de Tunis, Tunisia.
LA  - eng
PT  - Journal Article
DEP - 20170929
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
SB  - IM
MH  - Abortion, Habitual/*epidemiology/genetics
MH  - Adult
MH  - *Chromosome Aberrations
MH  - Chromosome Disorders/*epidemiology/genetics
MH  - Cohort Studies
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - Pregnancy
MH  - Prevalence
MH  - Translocation, Genetic
MH  - Tunisia/epidemiology
PMC - PMC5724954
OTO - NOTNLM
OT  - Recurrent miscarriage
OT  - chromosomal abnormalities
OT  - karyotype
EDAT- 2017/12/20 06:00
MHDA- 2017/12/23 06:00
CRDT- 2017/12/20 06:00
PHST- 2017/02/02 00:00 [received]
PHST- 2017/09/13 00:00 [accepted]
PHST- 2017/12/20 06:00 [entrez]
PHST- 2017/12/20 06:00 [pubmed]
PHST- 2017/12/23 06:00 [medline]
AID - 10.11604/pamj.2017.28.99.11879 [doi]
AID - PAMJ-28-99 [pii]
PST - epublish
SO  - Pan Afr Med J. 2017 Sep 29;28:99. doi: 10.11604/pamj.2017.28.99.11879.
      eCollection 2017.