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Effect of Age-Related Human Lens Sutures Growth on Its Fluid Dynamics.

Abstract Age-related nuclear cataract is the opacification of the clear ocular lens due to oxidative damage as we age, and is the leading cause of blindness in the world. A lack of antioxidant supply to the core of ever-growing ocular lens could contribute to the cause of this condition. In this project, a computational model was developed to study the sutural fluid inflow of the aging human lens.
PMID
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Authors

Mayor MeshTerms

Hydrodynamics

Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 29260191
OWN - NLM
STAT- MEDLINE
DCOM- 20171227
LR  - 20171227
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 14
DP  - 2017 Dec 1
TI  - Effect of Age-Related Human Lens Sutures Growth on Its Fluid Dynamics.
PG  - 6351-6357
LID - 10.1167/iovs.17-22099 [doi]
AB  - Purpose: Age-related nuclear cataract is the opacification of the clear ocular
      lens due to oxidative damage as we age, and is the leading cause of blindness in 
      the world. A lack of antioxidant supply to the core of ever-growing ocular lens
      could contribute to the cause of this condition. In this project, a computational
      model was developed to study the sutural fluid inflow of the aging human lens.
      Methods: Three different SOLIDWORKS computational fluid dynamics models of the
      human lens (7 years old; 28 years old; 46 years old) were created, based on
      available literature data. The fluid dynamics of the lens sutures were modelled
      using the Stokes flow equations, combined with realistic physiological boundary
      conditions and embedded in COMSOL Multiphysics. Results: The flow rate, volume,
      and flow rate per volume of fluid entering the aging lens were examined, and all 
      increased over the 40 years modelled. However, while the volume of the lens grew 
      by approximately 300% and the flow rate increased by approximately 400%, the flow
      rate per volume increased only by very moderate approximately 38%. Conclusions:
      Here, sutural information from humans of 7 to 46 years of age was obtained. In
      this modelled age range, an increase of flow rate per volume was observed, albeit
      at very slow rate. We hypothesize that with even further increasing age (60+
      years old), the lens volume growth would outpace its flow rate increases, which
      would eventually lead to malnutrition of the lens nucleus and onset of cataracts.
FAU - Wu, Ho-Ting D
AU  - Wu HD
AD  - School of Optometry and Vision Sciences, University of Auckland, New Zealand.
FAU - Howse, Louisa A
AU  - Howse LA
AD  - School of Optometry and Vision Sciences, University of Auckland, New Zealand.
FAU - Vaghefi, Ehsan
AU  - Vaghefi E
AD  - School of Optometry and Vision Sciences, University of Auckland, New Zealand.
AD  - Auckland Bioengineering Institute, University of Auckland, New Zealand.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - Cataract, Age-Related Nuclear
SB  - IM
MH  - Adult
MH  - Aging/*physiology
MH  - Cataract/*physiopathology
MH  - Child
MH  - Female
MH  - Humans
MH  - *Hydrodynamics
MH  - Lens, Crystalline/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Models, Theoretical
MH  - Oxidative Stress/physiology
EDAT- 2017/12/21 06:00
MHDA- 2017/12/28 06:00
CRDT- 2017/12/21 06:00
PHST- 2017/12/21 06:00 [entrez]
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2017/12/28 06:00 [medline]
AID - 2667031 [pii]
AID - 10.1167/iovs.17-22099 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Dec 1;58(14):6351-6357. doi:
      10.1167/iovs.17-22099.