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Corneal and Retinal Neuronal Degeneration in Early Stages of Diabetic Retinopathy.

Abstract To examine the neuronal structural integrity of cornea and retina as markers for neuronal degeneration in nonproliferative diabetic retinopathy (NPDR).
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 29260193
OWN - NLM
STAT- MEDLINE
DCOM- 20171227
LR  - 20171227
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 14
DP  - 2017 Dec 1
TI  - Corneal and Retinal Neuronal Degeneration in Early Stages of Diabetic
      Retinopathy.
PG  - 6365-6373
LID - 10.1167/iovs.17-22736 [doi]
AB  - Purpose: To examine the neuronal structural integrity of cornea and retina as
      markers for neuronal degeneration in nonproliferative diabetic retinopathy
      (NPDR). Methods: Participants were recruited from the broader Brisbane community,
      Queensland, Australia. Two hundred forty-one participants (187 with diabetes and 
      54 nondiabetic controls) were examined. Diabetic retinopathy (DR) was graded
      according to the Early Treatment Diabetic Retinopathy Study (ETDRS) scale.
      Corneal nerve fiber length (CNFL), corneal nerve branch density (CNBD), corneal
      nerve fiber tortuosity (CNFT), full retinal thickness, retinal nerve fiber layer 
      (RNFL), ganglion cell complex (GCC), focal (FLV) and global loss volumes (GLV),
      hemoglobin A1c (HbA1c), nephropathy, neuropathy, and cardiovascular measures were
      examined. Results: The central zone (P = 0.174), parafoveal thickness (P =
      0.090), perifovea (P = 0.592), RNFL (P = 0.866), GCC (P = 0.798), and GCC GLV (P 
      = 0.338) did not differ significantly between the groups. In comparison to the
      control group, those with very mild NPDR and those with mild NPDR had
      significantly higher focal loss in GCC volume (P = 0.036). CNFL was significantly
      lower in those with mild NPDR (P = 0.004) in comparison to the control group and 
      those with no DR. The CNBD (P = 0.094) and CNFT (P = 0.458) did not differ
      between the groups. Conclusions: Both corneal and retinal neuronal degeneration
      may occur in early stages of diabetic retinopathy. Further studies are required
      to examine these potential markers for neuronal degeneration in the absence of
      clinical signs of DR.
FAU - Srinivasan, Sangeetha
AU  - Srinivasan S
AD  - Institute of Health and Biomedical Innovation, Queensland University of
      Technology, Brisbane, Queensland, Australia.
FAU - Dehghani, Cirous
AU  - Dehghani C
AD  - Institute of Health and Biomedical Innovation, Queensland University of
      Technology, Brisbane, Queensland, Australia.
AD  - Commonwealth Scientific and Industrial Research Organisation (CSIRO), Parkville, 
      Victoria, Australia.
AD  - Poostchi Eye Research Centre, Department of Ophthalmology, School of Medicine,
      Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Pritchard, Nicola
AU  - Pritchard N
AD  - Institute of Health and Biomedical Innovation, Queensland University of
      Technology, Brisbane, Queensland, Australia.
FAU - Edwards, Katie
AU  - Edwards K
AD  - Institute of Health and Biomedical Innovation, Queensland University of
      Technology, Brisbane, Queensland, Australia.
FAU - Russell, Anthony W
AU  - Russell AW
AD  - Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
AD  - School of Medicine, University of Queensland, Woolloongabba, Queensland,
      Australia.
FAU - Malik, Rayaz A
AU  - Malik RA
AD  - Weill Cornell Medicine-Qatar, Education City, Doha, Qatar.
AD  - Central Manchester University Hospitals Foundation Trust, Manchester, United
      Kingdom.
FAU - Efron, Nathan
AU  - Efron N
AD  - Institute of Health and Biomedical Innovation, Queensland University of
      Technology, Brisbane, Queensland, Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Case-Control Studies
MH  - Cornea/*innervation
MH  - Diabetic Retinopathy/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Peripheral Nervous System Diseases/*pathology
MH  - Queensland
MH  - Retina/*pathology
MH  - Retinal Degeneration/*pathology
MH  - Retinal Ganglion Cells
MH  - Tomography, Optical Coherence
MH  - Young Adult
EDAT- 2017/12/21 06:00
MHDA- 2017/12/28 06:00
CRDT- 2017/12/21 06:00
PHST- 2017/12/21 06:00 [entrez]
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2017/12/28 06:00 [medline]
AID - 2667033 [pii]
AID - 10.1167/iovs.17-22736 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Dec 1;58(14):6365-6373. doi:
      10.1167/iovs.17-22736.