PubTransformer

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PMID- 29260199
OWN - NLM
STAT- MEDLINE
DCOM- 20171227
LR  - 20171227
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 14
DP  - 2017 Dec 1
TI  - Systemic Inflammation-Associated Proteins and Retinopathy of Prematurity in
      Infants Born Before the 28th Week of Gestation.
PG  - 6419-6428
LID - 10.1167/iovs.17-21931 [doi]
AB  - Purpose: To assess the association between systemic levels of
      inflammation-associated proteins and severe retinopathy of prematurity (ROP) in
      extremely preterm infants. Methods: We collected whole blood on filter paper on
      postnatal days 1, 7, 14, 21, and 28 from 1205 infants born before the 28th week
      of gestation, and measured the concentrations of 27 inflammation-associated,
      angiogenic, and neurotrophic proteins. We calculated odds ratios with 95%
      confidence intervals for the association between top quartile concentrations of
      each protein and prethreshold ROP. Results: During the first three weeks after
      birth, high concentrations of VEGF-R1, myeloperoxidase (MPO), IL-8, intercellular
      adhesion molecule (ICAM)-1, matrix metalloproteinase 9, erythropoietin,
      TNF-alpha, and basic fibroblast growth factor were associated with an increased
      risk for prethreshold ROP. On day 28, high levels of serum amyloid A, MPO, IL-6, 
      TNF-alpha, TNF-R1/-R2, IL-8, and ICAM-1 were associated with an increased risk.
      Top quartile concentrations of the proinflammatory cytokines TNF-alpha and IL-6
      were associated with increased risks of ROP when levels of neuroprotective
      proteins and growth factors, including BDNF, insulin-like growth factor 1,
      IGFBP-1, VEGFR-1 and -2, ANG-1 and PlGF, were not in the top quartile. In
      contrast, high concentrations of NT-4 and BDNF appeared protective only in
      infants without elevated inflammatory mediators. Conclusions: Systemic
      inflammation during the first postnatal month was associated with an increased
      risk of prethreshold ROP. Elevated concentrations of growth factors, angiogenic
      proteins, and neurotrophins appeared to modulate this risk, and were capable of
      reducing the risk even in the absence of systemic inflammation.
FAU - Holm, Mari
AU  - Holm M
AD  - Department of Clinical and Molecular Medicine, Faculty of Medicine, Norwegian
      University of Science and Technology, Trondheim, Norway.
AD  - Department of Pediatrics, St. Olavs Hospital, Trondheim University Hospital,
      Trondheim, Norway.
FAU - Morken, Tora S
AU  - Morken TS
AD  - Department of Neuromedicine and Movement Science (INB), Faculty of Medicine,
      Norwegian University of Science and Technology, Trondheim, Norway.
AD  - Department of Ophthalmology, St. Olavs Hospital, Trondheim University Hospital,
      Trondheim, Norway.
FAU - Fichorova, Raina N
AU  - Fichorova RN
AD  - Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and
      Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School,
      Boston, Massachusetts, United States.
FAU - VanderVeen, Deborah K
AU  - VanderVeen DK
AD  - Department of Ophthalmology, Children's Hospital Boston, Boston, Massachusetts,
      United States.
AD  - Department of Ophthalmology, Harvard Medical School, Harvard University, Boston, 
      Massachusetts, United States.
FAU - Allred, Elizabeth N
AU  - Allred EN
AD  - Department of Neurology, Boston Children's Hospital, Boston, Massachusetts,
      United States.
AD  - Department of Neurology, Harvard Medical School, Harvard University, Boston,
      Massachusetts, United States.
FAU - Dammann, Olaf
AU  - Dammann O
AD  - Department of Public Health and Community Medicine, Tufts University School of
      Medicine, Boston, Massachusetts, United States.
AD  - Perinatal Epidemiology Unit, Department of Gynecology and Obstetrics, Hannover
      Medical School, Hannover, Germany.
FAU - Leviton, Alan
AU  - Leviton A
AD  - Department of Neurology, Boston Children's Hospital, Boston, Massachusetts,
      United States.
AD  - Department of Neurology, Harvard Medical School, Harvard University, Boston,
      Massachusetts, United States.
CN  - ELGAN Study Neonatology and Ophthalmology Committees
LA  - eng
GR  - P30 HD018655/HD/NICHD NIH HHS/United States
GR  - R01 EY021820/EY/NEI NIH HHS/United States
GR  - U01 NS040069/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Eye Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Cytokines/metabolism
MH  - Eye Proteins/*metabolism
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Intercellular Signaling Peptides and Proteins/*metabolism
MH  - Nerve Growth Factors/metabolism
MH  - Odds Ratio
MH  - Prospective Studies
MH  - Retinopathy of Prematurity/*metabolism
PMC - PMC5736326
EDAT- 2017/12/21 06:00
MHDA- 2017/12/28 06:00
CRDT- 2017/12/21 06:00
PHST- 2017/12/21 06:00 [entrez]
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2017/12/28 06:00 [medline]
AID - 2667183 [pii]
AID - 10.1167/iovs.17-21931 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Dec 1;58(14):6419-6428. doi:
      10.1167/iovs.17-21931.