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High association of Cryptosporidium spp. infection with colon adenocarcinoma in Lebanese patients.

Abstract The association between Cryptosporidium and human colon cancer has been reported in different populations. However, this association has not been well studied. In order to add new strong arguments for a probable link between cryptosporidiosis and colon human cancer, the aim of this study was to determine prevalence and to identify species of Cryptosporidium among Lebanese patients.
PMID
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PMID- 29261714
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20180108
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 12
DP  - 2017
TI  - High association of Cryptosporidium spp. infection with colon adenocarcinoma in
      Lebanese patients.
PG  - e0189422
LID - 10.1371/journal.pone.0189422 [doi]
AB  - BACKGROUND: The association between Cryptosporidium and human colon cancer has
      been reported in different populations. However, this association has not been
      well studied. In order to add new strong arguments for a probable link between
      cryptosporidiosis and colon human cancer, the aim of this study was to determine 
      prevalence and to identify species of Cryptosporidium among Lebanese patients.
      METHODOLOGY AND PRINCIPAL FINDINGS: Overall, 218 digestive biopsies were
      collected in Tripoli, Lebanon, from three groups of patients: (i) patients with
      recently diagnosed colon intraepithelial neoplasia/adenocarcinoma before any
      treatment (n = 72); (ii) patients with recently diagnosed stomach intraepithelial
      neoplasia/adenocarcinoma before any treatment (n = 21); and (iii) patients
      without digestive intraepithelial neoplasia/adenocarcinoma but with persistent
      digestive symptoms (n = 125). DNA extraction was performed from paraffin-embedded
      tissue. The presence of the parasite in tissues was confirmed by PCR, microscopic
      observation and immunofluorescence analysis. We identified a high rate (21%) of
      Cryptosporidium presence in biopsies from Lebanese patients with recently
      diagnosed colonic neoplasia/adenocarcinoma before any treatment. This prevalence 
      was significantly higher compared to 7% of Cryptosporidium prevalence among
      patients without colon neoplasia but with persistent gastrointestinal symptoms
      (OR: 4, CI: 1.65-9.6, P = 0.001). When the comparison was done against normal
      biopsies, the risk of infection increased 11-fold in the group of patients with
      colon adenocarcinoma (OR: 11.315, CI: 1.44-89.02, P = 0.003). CONCLUSIONS: This
      is the first study performed in Lebanon reporting the prevalence of
      Cryptosporidium among patients with digestive cancer. These results show that
      Cryptosporidium is strongly associated with human colon cancer being maybe a
      potential etiological agent of this disease.
FAU - Osman, Marwan
AU  - Osman M
AD  - Institut Pasteur de Lille, Centre d'Infection et d'Immunite de Lille (CIIL), UMR 
      CNRS 8204, INSERM U1019, Universite de Lille, CHU de Lille, Biologie et Diversite
      des Pathogenes Eucaryotes Emergents (BDPEE), Lille, France.
AD  - Laboratoire Microbiologie Sante et Environnement (LMSE), Ecole Doctorale des
      Sciences et de Technologie, Faculte de Sante Publique, Universite Libanaise,
      Tripoli, Lebanon.
FAU - Benamrouz, Sadia
AU  - Benamrouz S
AD  - Institut Pasteur de Lille, Centre d'Infection et d'Immunite de Lille (CIIL), UMR 
      CNRS 8204, INSERM U1019, Universite de Lille, CHU de Lille, Biologie et Diversite
      des Pathogenes Eucaryotes Emergents (BDPEE), Lille, France.
AD  - Ecologie et Biodiversite, Faculte de Gestion, Economie et Sciences (FGES),
      Universite Catholique de Lille, Lille, France.
FAU - Guyot, Karine
AU  - Guyot K
AD  - Institut Pasteur de Lille, Centre d'Infection et d'Immunite de Lille (CIIL), UMR 
      CNRS 8204, INSERM U1019, Universite de Lille, CHU de Lille, Biologie et Diversite
      des Pathogenes Eucaryotes Emergents (BDPEE), Lille, France.
FAU - Baydoun, Martha
AU  - Baydoun M
AD  - Institut Pasteur de Lille, Centre d'Infection et d'Immunite de Lille (CIIL), UMR 
      CNRS 8204, INSERM U1019, Universite de Lille, CHU de Lille, Biologie et Diversite
      des Pathogenes Eucaryotes Emergents (BDPEE), Lille, France.
AD  - BioMEMS, Universite de Lille, CNRS, ISEN, UMR 8520 - IEMN, Lille, France.
AD  - BioGAP, groupe HEI-ISA-ISEN, Lille, France.
FAU - Frealle, Emilie
AU  - Frealle E
AD  - Institut Pasteur de Lille, Centre d'Infection et d'Immunite de Lille (CIIL), UMR 
      CNRS 8204, INSERM U1019, Universite de Lille, CHU de Lille, Biologie et Diversite
      des Pathogenes Eucaryotes Emergents (BDPEE), Lille, France.
AD  - Centre Hospitalier Regional et Universitaire de Lille & Faculte de Medecine de
      Lille, Universite Lille Nord de France, Laboratoire de Parasitologie-Mycologie,
      Centre de Biologie et Pathologie, Lille, France.
FAU - Chabe, Magali
AU  - Chabe M
AD  - Institut Pasteur de Lille, Centre d'Infection et d'Immunite de Lille (CIIL), UMR 
      CNRS 8204, INSERM U1019, Universite de Lille, CHU de Lille, Biologie et Diversite
      des Pathogenes Eucaryotes Emergents (BDPEE), Lille, France.
AD  - Faculte des sciences pharmaceutiques et biologiques, Universite Lille Nord de
      France, Departement de Parasitologie-Mycologie, Lille, France.
FAU - Gantois, Nausicaa
AU  - Gantois N
AD  - Institut Pasteur de Lille, Centre d'Infection et d'Immunite de Lille (CIIL), UMR 
      CNRS 8204, INSERM U1019, Universite de Lille, CHU de Lille, Biologie et Diversite
      des Pathogenes Eucaryotes Emergents (BDPEE), Lille, France.
FAU - Delaire, Baptiste
AU  - Delaire B
AD  - Service d'Anatomie et de Cytologie Pathologiques, Groupement des Hopitaux de
      l'Universite Catholique de Lille, Lille, France.
FAU - Goffard, Anne
AU  - Goffard A
AD  - Molecular and Cellular Virology, University Lille, CNRS, INSERM, CHU Lille,
      Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Centre d'Infection et d'Immunite
      de Lille, Lille, France.
FAU - Aoun, Albert
AU  - Aoun A
AD  - Pathology Department, Faculty of Medicine, American University of Beirut, Beirut,
      Lebanon.
FAU - Jurdi, Nawaf
AU  - Jurdi N
AD  - Pathology Department, Faculty of Medicine, American University of Beirut, Beirut,
      Lebanon.
FAU - Dabboussi, Fouad
AU  - Dabboussi F
AD  - Laboratoire Microbiologie Sante et Environnement (LMSE), Ecole Doctorale des
      Sciences et de Technologie, Faculte de Sante Publique, Universite Libanaise,
      Tripoli, Lebanon.
FAU - Even, Gael
AU  - Even G
AD  - Genes Difussion, Douai, France-PEGASE-Biosciences, Lille, France.
FAU - Slomianny, Christian
AU  - Slomianny C
AD  - Laboratory of Cell Physiology, INSERM U 1003, Universite de Lille, Villeneuve
      d'Ascq, France.
FAU - Gosset, Pierre
AU  - Gosset P
AD  - Service d'Anatomie et de Cytologie Pathologiques, Groupement des Hopitaux de
      l'Universite Catholique de Lille, Lille, France.
FAU - Hamze, Monzer
AU  - Hamze M
AD  - Laboratoire Microbiologie Sante et Environnement (LMSE), Ecole Doctorale des
      Sciences et de Technologie, Faculte de Sante Publique, Universite Libanaise,
      Tripoli, Lebanon.
FAU - Creusy, Colette
AU  - Creusy C
AD  - Service d'Anatomie et de Cytologie Pathologiques, Groupement des Hopitaux de
      l'Universite Catholique de Lille, Lille, France.
FAU - Viscogliosi, Eric
AU  - Viscogliosi E
AD  - Institut Pasteur de Lille, Centre d'Infection et d'Immunite de Lille (CIIL), UMR 
      CNRS 8204, INSERM U1019, Universite de Lille, CHU de Lille, Biologie et Diversite
      des Pathogenes Eucaryotes Emergents (BDPEE), Lille, France.
FAU - Certad, Gabriela
AU  - Certad G
AUID- ORCID: http://orcid.org/0000-0003-0827-3188
AD  - Institut Pasteur de Lille, Centre d'Infection et d'Immunite de Lille (CIIL), UMR 
      CNRS 8204, INSERM U1019, Universite de Lille, CHU de Lille, Biologie et Diversite
      des Pathogenes Eucaryotes Emergents (BDPEE), Lille, France.
AD  - Departement de la Recherche Medicale, Groupement des Hopitaux de l'Institut
      Catholique de Lille, Faculte de Medecine et Maieutique, Universite Catholique de 
      Lille, Lille, France.
LA  - eng
PT  - Journal Article
DEP - 20171219
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adenocarcinoma/complications/*epidemiology/*parasitology/pathology
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy
MH  - Case-Control Studies
MH  - Colonic Neoplasms/complications/*epidemiology/*parasitology/pathology
MH  - Cryptosporidiosis/*complications
MH  - Cryptosporidium/*physiology
MH  - Female
MH  - Humans
MH  - Lebanon/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Young Adult
PMC - PMC5736188
EDAT- 2017/12/21 06:00
MHDA- 2018/01/09 06:00
CRDT- 2017/12/21 06:00
PHST- 2017/06/06 00:00 [received]
PHST- 2017/11/24 00:00 [accepted]
PHST- 2017/12/21 06:00 [entrez]
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
AID - 10.1371/journal.pone.0189422 [doi]
AID - PONE-D-17-21656 [pii]
PST - epublish
SO  - PLoS One. 2017 Dec 19;12(12):e0189422. doi: 10.1371/journal.pone.0189422.
      eCollection 2017.