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PMID- 29261752
OWN - NLM
STAT- In-Process
LR  - 20171224
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 12
DP  - 2017
TI  - A comparison of health-related quality of life (HRQoL) across four systemic
      autoimmune rheumatic diseases (SARDs).
PG  - e0189840
LID - 10.1371/journal.pone.0189840 [doi]
AB  - OBJECTIVES: To compare physical and mental health-related quality of life (HRQoL)
      across four systemic autoimmune rheumatic diseases (SARD). METHODS: Incident
      subjects enrolled in four SARD cohorts, namely systemic lupus erythematosus
      (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA) and idiopathic
      inflammatory myopathies (IIM) were studied. The outcomes of interest were
      baseline Short Form Health Survey physical (PCS) and mental (MCS) component
      summary scores. Multivariate analysis was conducted to determine whether PCS and 
      MCS scores differed across SARD type. RESULTS: The study included 118 SLE (93%
      women, mean age 36 years), 108 SSc (79% women, mean age 55), 64 RA (63% women,
      mean age 58) and 25 IIM (68% women, mean age 49) subjects. Mean PCS scores were
      38.9 +/- 12.2 in SLE, 37.1 +/- 13.3 in RA, 35.0 +/- 13.6 in SSc and 28.0 +/- 15.4
      in IIM. Mean MCS scores were 45.0 +/- 13.3 in RA, 44.4 +/- 14.7 in SSc, 40.1 +/- 
      14.3 in SLE and 33.6 +/- 18.7 in IIM. SARD type was an independent predictor of
      HRQoL with, in some cases, the magnitude of the differences reaching one standard
      deviation (IIM worse PCS scores compared to SLE (beta -12.23 [95% CI -18.11,
      -6.36; p<0.001]); IIM worse MCS scores compared to SSc (beta -11.05 [95% CI
      -17.53, -4.58; p = 0.001]) and RA (beta -11.72 [95% CI -18.62, -4.81; p =
      0.001]). CONCLUSIONS: Cross-SARD research provides a novel approach to gain
      greater understanding of commonalities and differences across rheumatic diseases.
      The differences observed warrant further research into correlates and
      trajectories over time.
FAU - Greenfield, Julia
AU  - Greenfield J
AD  - Department of Anatomy McGill University, Montreal, Quebec, Canada.
AD  - Medicine, McGill University, Montreal, Quebec, Canada.
FAU - Hudson, Marie
AU  - Hudson M
AD  - Medicine, McGill University, Montreal, Quebec, Canada.
AD  - Division of Rheumatology Jewish General Hospital, Montreal, Quebec, Canada.
AD  - Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.
FAU - Vinet, Evelyne
AU  - Vinet E
AD  - Medicine, McGill University, Montreal, Quebec, Canada.
AD  - Division of Rheumatology, McGill University Health Center, Montreal, Quebec,
      Canada.
FAU - Fortin, Paul R
AU  - Fortin PR
AD  - Division of Rheumatology, Department of Medicine, Centre Hospitalier
      Universitaire de Quebec, Quebec City, Quebec, Canada.
AD  - Universite Laval, Quebec City, Quebec, Canada.
FAU - Bykerk, Vivian
AU  - Bykerk V
AD  - Division of Rheumatology, Hospital for Special Surgery, Cornell University, New
      York, New York, United States of America.
FAU - Pineau, Christian A
AU  - Pineau CA
AD  - Medicine, McGill University, Montreal, Quebec, Canada.
AD  - Division of Rheumatology, McGill University Health Center, Montreal, Quebec,
      Canada.
FAU - Wang, Mianbo
AU  - Wang M
AD  - Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.
FAU - Bernatsky, Sasha
AU  - Bernatsky S
AD  - Medicine, McGill University, Montreal, Quebec, Canada.
AD  - Division of Rheumatology, McGill University Health Center, Montreal, Quebec,
      Canada.
FAU - Baron, Murray
AU  - Baron M
AD  - Medicine, McGill University, Montreal, Quebec, Canada.
AD  - Division of Rheumatology Jewish General Hospital, Montreal, Quebec, Canada.
AD  - Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.
CN  - Canadian Scleroderma Research Group and Canadian Inflammatory Myopathy Study
      Group
LA  - eng
PT  - Journal Article
DEP - 20171219
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
PMC - PMC5736192
EDAT- 2017/12/21 06:00
MHDA- 2017/12/21 06:00
CRDT- 2017/12/21 06:00
PHST- 2016/05/19 00:00 [received]
PHST- 2017/12/02 00:00 [accepted]
PHST- 2017/12/21 06:00 [entrez]
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2017/12/21 06:00 [medline]
AID - 10.1371/journal.pone.0189840 [doi]
AID - PONE-D-16-20249 [pii]
PST - epublish
SO  - PLoS One. 2017 Dec 19;12(12):e0189840. doi: 10.1371/journal.pone.0189840.
      eCollection 2017.