PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: A systematic review and meta-analysis of preclinical studies.

Abstract Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating neurologic condition with high mortality rates and long-term complications for surviving infants. Mesenchymal stem/stromal cells (MSCs) have emerged as novel therapeutic agents with promising results in experimental studies of HIE. The purpose of this study is to (a) methodically review the current preclinical literature describing MSC therapy in animal models of HIE, (b) quantify the effect size in regards to functional neurologic outcome, and (c) identify research gaps/limitations that should be addressed prior to future preclinical and clinical studies.
PMID
Related Publications

Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants.

Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review.

Endogenous hypothermic response to hypoxia reduces brain injury: Implications for modeling hypoxic-ischemic encephalopathy and therapeutic hypothermia in neonatal mice.

Systematic review and meta-analysis of efficacy of mesenchymal stem cells on locomotor recovery in animal models of traumatic brain injury.

Authors

Mayor MeshTerms
Keywords
Journal Title plos one
Publication Year Start




PMID- 29261798
OWN - NLM
STAT- In-Process
LR  - 20171224
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 12
DP  - 2017
TI  - Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic
      encephalopathy: A systematic review and meta-analysis of preclinical studies.
PG  - e0189895
LID - 10.1371/journal.pone.0189895 [doi]
AB  - INTRODUCTION: Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating
      neurologic condition with high mortality rates and long-term complications for
      surviving infants. Mesenchymal stem/stromal cells (MSCs) have emerged as novel
      therapeutic agents with promising results in experimental studies of HIE. The
      purpose of this study is to (a) methodically review the current preclinical
      literature describing MSC therapy in animal models of HIE, (b) quantify the
      effect size in regards to functional neurologic outcome, and (c) identify
      research gaps/limitations that should be addressed prior to future preclinical
      and clinical studies. METHODS: Adhering to the Systematic Review Protocol for
      Animal Intervention Studies, a systematic search of English articles was
      performed. Eligible studies were identified and data regarding study
      characteristics and outcome measures was extracted. After quality assessment,
      meta-analysis and meta-regression were performed to generate random effect size
      using standardized mean difference (SMD). Funnel plots and Egger's tests were
      utilized to evaluate for the presence of publication bias. RESULTS: A total of 19
      studies met inclusion in the current systematic review. Meta-analysis revealed
      that MSCs have a significant positive effect on neurobehavioral outcome following
      HIE injury. Sensorimotor function was improved by 2.25 SMD (95% CI; 2.04-2.46) in
      cylinder rearing and 2.97 SMD (95% CI; 2.56-3.38) in rotarod. Likewise, cognitive
      function was improved by 2.76 SMD (95% CI; 2.53-2.98) on the water maze and 2.97 
      SMD (95% CI; 2.58-3.35) in object recognition. Stratification demonstrated an
      increased effect size depending on various study characteristics. CONCLUSIONS:
      Overall, these results suggest a promising role for MSCs in preclinical studies
      of HIE. MSC treatment demonstrates improved functional outcomes that are
      encouraging for future translational studies. While risk of bias and
      heterogeneity limited the strength of our meta-analysis, our results are
      consistent with those seen in this field of research.
FAU - Archambault, Jamie
AU  - Archambault J
AUID- ORCID: http://orcid.org/0000-0002-3878-431X
AD  - Department of Pediatrics, Division of Neonatology, University of Texas Health-San
      Antonio, San Antonio, Texas, United States of America.
FAU - Moreira, Alvaro
AU  - Moreira A
AD  - Department of Pediatrics, Division of Neonatology, University of Texas Health-San
      Antonio, San Antonio, Texas, United States of America.
FAU - McDaniel, Dawn
AU  - McDaniel D
AD  - Department of Pediatrics, Division of Neonatology, University of Texas Health-San
      Antonio, San Antonio, Texas, United States of America.
FAU - Winter, Lauryn
AU  - Winter L
AD  - Department of Pediatrics, Division of Neonatology, University of Texas Health-San
      Antonio, San Antonio, Texas, United States of America.
FAU - Sun, LuZhe
AU  - Sun L
AD  - Department of Cell Systems and Anatomy, University of Texas Health-San Antonio,
      San Antonio, Texas, United States of America.
FAU - Hornsby, Peter
AU  - Hornsby P
AD  - Department of Cellular and Integrative Physiology, Barshop Institute for
      Longevity and Aging Studies, University of Texas Health-San Antonio, San Antonio,
      Texas, United States of America.
LA  - eng
PT  - Journal Article
DEP - 20171219
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
PMC - PMC5736208
EDAT- 2017/12/21 06:00
MHDA- 2017/12/21 06:00
CRDT- 2017/12/21 06:00
PHST- 2017/09/01 00:00 [received]
PHST- 2017/12/04 00:00 [accepted]
PHST- 2017/12/21 06:00 [entrez]
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2017/12/21 06:00 [medline]
AID - 10.1371/journal.pone.0189895 [doi]
AID - PONE-D-17-32089 [pii]
PST - epublish
SO  - PLoS One. 2017 Dec 19;12(12):e0189895. doi: 10.1371/journal.pone.0189895.
      eCollection 2017.