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Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection.

Abstract Type-2-cell-mediated immune responses play a critical role in mediating both host-resistance and disease-tolerance mechanisms during helminth infections. Recently, type 2 cell responses have emerged as major regulators of tissue repair and metabolic homeostasis even under steady-state conditions. In this review, we consider how studies of helminth infection have contributed toward our expanding cellular and molecular understanding of type-2-cell-mediated immunity, as well as new areas such as the microbiome. By studying how these successful parasites form chronic infections without overt pathology, we are gaining additional insights into allergic and inflammatory diseases, as well as normal physiology.
PMID
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Authors

Mayor MeshTerms

Immunity, Cellular

Keywords
Journal Title immunity
Publication Year Start




PMID- 29262347
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20171226
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Linking)
VI  - 47
IP  - 6
DP  - 2017 Dec 19
TI  - Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth
      Infection.
PG  - 1024-1036
LID - S1074-7613(17)30516-2 [pii]
LID - 10.1016/j.immuni.2017.11.015 [doi]
AB  - Type-2-cell-mediated immune responses play a critical role in mediating both
      host-resistance and disease-tolerance mechanisms during helminth infections.
      Recently, type 2 cell responses have emerged as major regulators of tissue repair
      and metabolic homeostasis even under steady-state conditions. In this review, we 
      consider how studies of helminth infection have contributed toward our expanding 
      cellular and molecular understanding of type-2-cell-mediated immunity, as well as
      new areas such as the microbiome. By studying how these successful parasites form
      chronic infections without overt pathology, we are gaining additional insights
      into allergic and inflammatory diseases, as well as normal physiology.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Harris, Nicola L
AU  - Harris NL
AD  - Global Health Institute, Ecole Polytechnique Federale de Lausanne, Lausanne 1015,
      Switzerland. Electronic address: [email protected]
FAU - Loke, P'ng
AU  - Loke P
AD  - Department of Microbiology, New York University School of Medicine, New York, NY,
      USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines/genetics/immunology
MH  - Epithelial Cells/immunology/parasitology
MH  - Gene Expression Regulation/immunology
MH  - Helminthiasis/genetics/*immunology/parasitology
MH  - Homeostasis/immunology
MH  - Host-Parasite Interactions/immunology
MH  - Humans
MH  - *Immunity, Cellular
MH  - Macrophages/*immunology/parasitology
MH  - Mast Cells/immunology/parasitology
MH  - Microbiota/immunology
MH  - Nematoda/*immunology
MH  - Th2 Cells/*immunology/parasitology
MH  - Trematoda/*immunology
EDAT- 2017/12/21 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/12/21 06:00
PHST- 2017/06/09 00:00 [received]
PHST- 2017/11/06 00:00 [revised]
PHST- 2017/11/16 00:00 [accepted]
PHST- 2017/12/21 06:00 [entrez]
PHST- 2017/12/21 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - S1074-7613(17)30516-2 [pii]
AID - 10.1016/j.immuni.2017.11.015 [doi]
PST - ppublish
SO  - Immunity. 2017 Dec 19;47(6):1024-1036. doi: 10.1016/j.immuni.2017.11.015.