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Effects of Salvia miltiorrhiza extract with supplemental liquefied calcium on osteoporosis in calcium-deficient ovariectomized mice.

Abstract Extracts from Salvia miltiorrhiza Bunge have been used in traditional Asian medicine to treat coronary heart disease, chronic renal failure, atherosclerosis, myocardial infraction, angina pectoris, myocardial ischemia, dysmenorrheal, neurasthenic insomnia, liver fibrosis and cirrhosis. The aim of the study was to investigate the anti-RANK signal effect of the combination of S.miltiorrhiza Bunge (SME) and liquefied calcium (LCa) supplement with ovariectomized (OVX-SML) mice, a osteoporosis animal model. Results were compared to 17β-estradiol (E2) treatment.
PMID
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Authors

Mayor MeshTerms
Keywords

Liquefied calcium supplement

OPG

Ovariectomized mice

RANKL

Salvia miltiorrhiza Bunge

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 29262817
OWN - NLM
STAT- In-Process
LR  - 20171221
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Dec 20
TI  - Effects of Salvia miltiorrhiza extract with supplemental liquefied calcium on
      osteoporosis in calcium-deficient ovariectomized mice.
PG  - 545
LID - 10.1186/s12906-017-2047-y [doi]
AB  - BACKGROUND: Extracts from Salvia miltiorrhiza Bunge have been used in traditional
      Asian medicine to treat coronary heart disease, chronic renal failure,
      atherosclerosis, myocardial infraction, angina pectoris, myocardial ischemia,
      dysmenorrheal, neurasthenic insomnia, liver fibrosis and cirrhosis. The aim of
      the study was to investigate the anti-RANK signal effect of the combination of
      S.miltiorrhiza Bunge (SME) and liquefied calcium (LCa) supplement with
      ovariectomized (OVX-SML) mice, a osteoporosis animal model. Results were compared
      to 17beta-estradiol (E2) treatment. METHODS: A total of 70 female ICR strain mice
      (7 weeks) were randomly divided into 10 groups with 7 mice in each group as
      follows: (1) sham-operated control mice (sham) received daily oral
      phosphate-buffered-saline (PBS) of equal volumes through oral administration. (2)
      OVX mice received a daily oral administration of PBS (OVX). (3) OVX mice treated 
      daily with 50 mg/kg b.w./ day of SME (4) with 100 mg/kg b.w./day of SME or (5)
      with 200 mg/kg b.w./day of SME via oral administration. (6) OVX mice treated
      daily with 50 mg/kg b.w./day of SML (7) with 100 mg/kg b.w./day of SML or (8)
      with 200 mg/kg b.w./day of SML via oral administration. (9) OVX mice treated
      daily with 10 ml/kg b.w./day of LCa (10) OVX mice received i.p. injections of
      17beta-estradiol (E2) (0.1 mg/kg b.w./day) three times per week for 12 weeks.
      RESULTS: micro-CT analysis revealed that oral administration of SML inhibited
      tibial bone loss, sustained trabecular bone state, and ameliorated bone
      biochemical markers. In addition, SML administration compared to SEM and LCa
      reduced serum levels of RANKL, osteocalcin and BALP through increased serum
      levels of OPG and E2 in OVX mice. SML also had more beneficial effects on
      protection of estrogen-dependent bone loss through blocking expression of TRAF6
      and NFTAc1 and produces cathepsin K and calcitonin receptor to develop osteoclast
      differentiation. CONCLUSION: These data suggest that S. miltiorrhiza Bunge
      combined with liquefied calcium supplement has an inhibitory activity in OVX
      mice. This result implies the possibility of a pharmacological intervention
      specifically directed toward a disease such as osteoporosis where decreased bone 
      strength increases the risk of a broken bone .
FAU - Park, Bongkyun
AU  - Park B
AD  - Department of Oriental Medicine and Biotechnology, College of Life Science, Kyung
      Hee University, Yongin-si, 17104, Republic of Korea.
FAU - Song, Hae Seong
AU  - Song HS
AD  - Department of Oriental Medicine and Biotechnology, College of Life Science, Kyung
      Hee University, Yongin-si, 17104, Republic of Korea.
FAU - Kwon, Jeong Eun
AU  - Kwon JE
AD  - Department of Oriental Medicine and Biotechnology, College of Life Science, Kyung
      Hee University, Yongin-si, 17104, Republic of Korea.
FAU - Cho, Se Min
AU  - Cho SM
AD  - Department of Oriental Medicine and Biotechnology, College of Life Science, Kyung
      Hee University, Yongin-si, 17104, Republic of Korea.
FAU - Jang, Seon-A
AU  - Jang SA
AD  - Department of Oriental Medicine and Biotechnology, College of Life Science, Kyung
      Hee University, Yongin-si, 17104, Republic of Korea.
FAU - Kim, Mi Yeon
AU  - Kim MY
AD  - KMF Co., Ltd., Yulam-ro 12, Dong-gu, Daegu-si, 41065, Republic of Korea.
FAU - Kang, Se Chan
AU  - Kang SC
AD  - Department of Oriental Medicine and Biotechnology, College of Life Science, Kyung
      Hee University, Yongin-si, 17104, Republic of Korea. [email protected]
LA  - eng
GR  - KHU-20160597/Kyung Hee University (KR)/United States
PT  - Journal Article
DEP - 20171220
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
OTO - NOTNLM
OT  - Liquefied calcium supplement
OT  - OPG
OT  - Ovariectomized mice
OT  - RANKL
OT  - Salvia miltiorrhiza Bunge
EDAT- 2017/12/22 06:00
MHDA- 2017/12/22 06:00
CRDT- 2017/12/22 06:00
PHST- 2017/09/22 00:00 [received]
PHST- 2017/12/06 00:00 [accepted]
PHST- 2017/12/22 06:00 [entrez]
PHST- 2017/12/22 06:00 [pubmed]
PHST- 2017/12/22 06:00 [medline]
AID - 10.1186/s12906-017-2047-y [doi]
AID - 10.1186/s12906-017-2047-y [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Dec 20;17(1):545. doi: 10.1186/s12906-017-2047-y.