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Inflammatory biomarkers of low back pain and disc degeneration: a review.

Abstract Biomarkers are biological characteristics that can be used to indicate health or disease. This paper reviews studies on biomarkers of low back pain (LBP) in human subjects. LBP is the leading cause of disability, caused by various spine-related disorders, including intervertebral disc degeneration, disc herniation, spinal stenosis, and facet arthritis. The focus of these studies is inflammatory mediators, because inflammation contributes to the pathogenesis of disc degeneration and associated pain mechanisms. Increasingly, studies suggest that the presence of inflammatory mediators can be measured systemically in the blood. These biomarkers may serve as novel tools for directing patient care. Currently, patient response to treatment is unpredictable with a significant rate of recurrence, and, while surgical treatments may provide anatomical correction and pain relief, they are invasive and costly. The review covers studies performed on populations with specific diagnoses and undefined origins of LBP. Since the natural history of LBP is progressive, the temporal nature of studies is categorized by duration of symptomology/disease. Related studies on changes in biomarkers with treatment are also reviewed. Ultimately, diagnostic biomarkers of LBP and spinal degeneration have the potential to shepherd an era of individualized spine medicine for personalized therapeutics in the treatment of LBP.
PMID
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Authors

Mayor MeshTerms
Keywords

back pain

biomarkers

inflammation

intervertebral disc degeneration

spine

Journal Title annals of the new york academy of sciences
Publication Year Start




PMID- 29265416
OWN - NLM
STAT- MEDLINE
DCOM- 20180109
LR  - 20180109
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1410
IP  - 1
DP  - 2017 Dec
TI  - Inflammatory biomarkers of low back pain and disc degeneration: a review.
PG  - 68-84
LID - 10.1111/nyas.13551 [doi]
AB  - Biomarkers are biological characteristics that can be used to indicate health or 
      disease. This paper reviews studies on biomarkers of low back pain (LBP) in human
      subjects. LBP is the leading cause of disability, caused by various spine-related
      disorders, including intervertebral disc degeneration, disc herniation, spinal
      stenosis, and facet arthritis. The focus of these studies is inflammatory
      mediators, because inflammation contributes to the pathogenesis of disc
      degeneration and associated pain mechanisms. Increasingly, studies suggest that
      the presence of inflammatory mediators can be measured systemically in the blood.
      These biomarkers may serve as novel tools for directing patient care. Currently, 
      patient response to treatment is unpredictable with a significant rate of
      recurrence, and, while surgical treatments may provide anatomical correction and 
      pain relief, they are invasive and costly. The review covers studies performed on
      populations with specific diagnoses and undefined origins of LBP. Since the
      natural history of LBP is progressive, the temporal nature of studies is
      categorized by duration of symptomology/disease. Related studies on changes in
      biomarkers with treatment are also reviewed. Ultimately, diagnostic biomarkers of
      LBP and spinal degeneration have the potential to shepherd an era of
      individualized spine medicine for personalized therapeutics in the treatment of
      LBP.
CI  - (c) 2017 New York Academy of Sciences.
FAU - Khan, Aysha N
AU  - Khan AN
AD  - The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New
      York.
FAU - Jacobsen, Hayley E
AU  - Jacobsen HE
AD  - Department of Orthopedic Surgery, Columbia University, New York, New York.
FAU - Khan, Jansher
AU  - Khan J
AD  - The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New
      York.
FAU - Filippi, Christopher G
AU  - Filippi CG
AD  - Lenox Hill Hospital, Northwell Health, New York, New York.
FAU - Levine, Mitchell
AU  - Levine M
AD  - Lenox Hill Hospital, Northwell Health, New York, New York.
FAU - Lehman, Ronald A Jr
AU  - Lehman RA Jr
AD  - Department of Orthopedic Surgery, Columbia University, New York, New York.
AD  - New York-Presbyterian-Spine Hospital, New York, New York.
FAU - Riew, K Daniel
AU  - Riew KD
AD  - Department of Orthopedic Surgery, Columbia University, New York, New York.
AD  - New York-Presbyterian-Spine Hospital, New York, New York.
FAU - Lenke, Lawrence G
AU  - Lenke LG
AD  - Department of Orthopedic Surgery, Columbia University, New York, New York.
AD  - New York-Presbyterian-Spine Hospital, New York, New York.
FAU - Chahine, Nadeen O
AU  - Chahine NO
AUID- ORCID: http://orcid.org/0000-0002-0478-6042
AD  - Department of Orthopedic Surgery, Columbia University, New York, New York.
AD  - Department of Biomedical Engineering, Columbia University, New York, New York.
LA  - eng
GR  - R01 AR069668/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Biomarkers/*blood
MH  - Cytokines/blood
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Intervertebral Disc Degeneration/*blood/diagnosis/therapy
MH  - Low Back Pain/*blood/diagnosis/therapy
MH  - Outcome Assessment (Health Care)/methods
MH  - Sensitivity and Specificity
PMC - PMC5744892
MID - NIHMS914519
OTO - NOTNLM
OT  - back pain
OT  - biomarkers
OT  - inflammation
OT  - intervertebral disc degeneration
OT  - spine
EDAT- 2017/12/22 06:00
MHDA- 2018/01/10 06:00
CRDT- 2017/12/22 06:00
PMCR- 2018/12/01 00:00
PHST- 2017/07/05 00:00 [received]
PHST- 2017/10/12 00:00 [revised]
PHST- 2017/10/18 00:00 [accepted]
PHST- 2018/12/01 00:00 [pmc-release]
PHST- 2017/12/22 06:00 [entrez]
PHST- 2017/12/22 06:00 [pubmed]
PHST- 2018/01/10 06:00 [medline]
AID - 10.1111/nyas.13551 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2017 Dec;1410(1):68-84. doi: 10.1111/nyas.13551.