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Bone quality changes associated with aging and disease: a review.

Abstract Bone quality encompasses all the characteristics of bone that, in addition to density, contribute to its resistance to fracture. In this review, we consider changes in architecture, porosity, and composition, including collagen structure, mineral composition, and crystal size. These factors all are known to vary with tissue and animal ages, and health status. Bone morphology and presence of microcracks, which also contribute to bone quality, will not be discussed in this review. Correlations with mechanical performance for collagen cross-linking, crystallinity, and carbonate content are contrasted with mineral content. Age-dependent changes in humans and rodents are discussed in relation to rodent models of disease. Examples are osteoporosis, osteomalacia, osteogenesis imperfecta (OI), and osteopetrosis in both humans and animal models. Each of these conditions, along with aging, is associated with increased fracture risk for distinct reasons.
PMID
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Authors

Mayor MeshTerms

Aging

Bone Density

Keywords

FTIR imaging

bone composition

microCT

osteogenesis imperfecta

osteoporosis

Journal Title annals of the new york academy of sciences
Publication Year Start




PMID- 29265417
OWN - NLM
STAT- MEDLINE
DCOM- 20180109
LR  - 20180109
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1410
IP  - 1
DP  - 2017 Dec
TI  - Bone quality changes associated with aging and disease: a review.
PG  - 93-106
LID - 10.1111/nyas.13572 [doi]
AB  - Bone quality encompasses all the characteristics of bone that, in addition to
      density, contribute to its resistance to fracture. In this review, we consider
      changes in architecture, porosity, and composition, including collagen structure,
      mineral composition, and crystal size. These factors all are known to vary with
      tissue and animal ages, and health status. Bone morphology and presence of
      microcracks, which also contribute to bone quality, will not be discussed in this
      review. Correlations with mechanical performance for collagen cross-linking,
      crystallinity, and carbonate content are contrasted with mineral content.
      Age-dependent changes in humans and rodents are discussed in relation to rodent
      models of disease. Examples are osteoporosis, osteomalacia, osteogenesis
      imperfecta (OI), and osteopetrosis in both humans and animal models. Each of
      these conditions, along with aging, is associated with increased fracture risk
      for distinct reasons.
CI  - (c) 2017 New York Academy of Sciences.
FAU - Boskey, Adele L
AU  - Boskey AL
AD  - Mineralized Tissue Laboratory, Hospital for Special Surgery, New York, New York.
AD  - Department of Biochemistry, Weill Cornell Medical College, New York, New York.
FAU - Imbert, Laurianne
AU  - Imbert L
AD  - Mineralized Tissue Laboratory, Hospital for Special Surgery, New York, New York.
LA  - eng
GR  - R01 AR041325/AR/NIAMS NIH HHS/United States
GR  - R01 DE004141/DE/NIDCR NIH HHS/United States
GR  - R37 DE004141/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Minerals)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - *Bone Density
MH  - Bone Diseases/*metabolism
MH  - Bone and Bones/*metabolism
MH  - Disease Models, Animal
MH  - Fractures, Bone/metabolism
MH  - Humans
MH  - Minerals/metabolism
MH  - Risk Factors
OTO - NOTNLM
OT  - FTIR imaging
OT  - bone composition
OT  - microCT
OT  - osteogenesis imperfecta
OT  - osteoporosis
EDAT- 2017/12/22 06:00
MHDA- 2018/01/10 06:00
CRDT- 2017/12/22 06:00
PHST- 2017/07/07 00:00 [received]
PHST- 2017/11/11 00:00 [revised]
PHST- 2017/11/13 00:00 [accepted]
PHST- 2017/12/22 06:00 [entrez]
PHST- 2017/12/22 06:00 [pubmed]
PHST- 2018/01/10 06:00 [medline]
AID - 10.1111/nyas.13572 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2017 Dec;1410(1):93-106. doi: 10.1111/nyas.13572.