PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Current perspectives on biological approaches for osteoarthritis.

Abstract Musculoskeletal injuries that disrupt the structure and function of diarthrodial joints can cause permanent biomechanical alterations and lead to a more severe, chronic condition. Despite advancements that have been made to restore tissue function and delay the need for joint replacement, there are currently no disease-modifying therapies for osteoarthritis (OA). To reduce the risk of OA, innovative preventive medicine approaches have been developed over the last decade to treat the underlying pathology. Several biological approaches are promising treatment modalities for various stages of OA owing to their minimally invasive nature and actively dynamic physiological mechanisms that attenuate tissue degradation and inflammatory responses. Individualized growth factor and cytokine therapies, tissue-engineered biomaterials, and cell-based therapies have revolutionary potential for orthopedic applications; however, the paucity of standardization and categorization of biological components and their counterparts has made it difficult to determine their clinical and biological efficacy. Cell-based therapies and tissue-engineered biologics have become lucrative in sports medicine and orthopedics; nonetheless, there is a continued effort to produce a biological treatment modality tailored to target intra-articular structures that recapitulates tissue function. Advanced development of these biological treatment modalities will potentially optimize tissue healing, regeneration, and joint preservation strategies. Therefore, the purpose of this paper is to review current concepts on several biological treatment approaches for OA.
PMID
Related Publications

Tissue engineering and regenerative medicine: past, present, and future.

Musculoskeletal diseases--tendon.

Stem cell-based therapies for osteoarthritis: challenges and opportunities.

Tissue engineering of ligaments for reconstructive surgery.

Regenerative approaches for the treatment of early OA.

Authors

Mayor MeshTerms

Platelet-Rich Plasma

Keywords

growth factor and cytokine therapy

stem cell therapy

tissue engineering

Journal Title annals of the new york academy of sciences
Publication Year Start




PMID- 29265418
OWN - NLM
STAT- MEDLINE
DCOM- 20180109
LR  - 20180109
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1410
IP  - 1
DP  - 2017 Dec
TI  - Current perspectives on biological approaches for osteoarthritis.
PG  - 26-43
LID - 10.1111/nyas.13554 [doi]
AB  - Musculoskeletal injuries that disrupt the structure and function of diarthrodial 
      joints can cause permanent biomechanical alterations and lead to a more severe,
      chronic condition. Despite advancements that have been made to restore tissue
      function and delay the need for joint replacement, there are currently no
      disease-modifying therapies for osteoarthritis (OA). To reduce the risk of OA,
      innovative preventive medicine approaches have been developed over the last
      decade to treat the underlying pathology. Several biological approaches are
      promising treatment modalities for various stages of OA owing to their minimally 
      invasive nature and actively dynamic physiological mechanisms that attenuate
      tissue degradation and inflammatory responses. Individualized growth factor and
      cytokine therapies, tissue-engineered biomaterials, and cell-based therapies have
      revolutionary potential for orthopedic applications; however, the paucity of
      standardization and categorization of biological components and their
      counterparts has made it difficult to determine their clinical and biological
      efficacy. Cell-based therapies and tissue-engineered biologics have become
      lucrative in sports medicine and orthopedics; nonetheless, there is a continued
      effort to produce a biological treatment modality tailored to target
      intra-articular structures that recapitulates tissue function. Advanced
      development of these biological treatment modalities will potentially optimize
      tissue healing, regeneration, and joint preservation strategies. Therefore, the
      purpose of this paper is to review current concepts on several biological
      treatment approaches for OA.
CI  - (c) 2017 New York Academy of Sciences.
FAU - Whitney, Kaitlyn E
AU  - Whitney KE
AUID- ORCID: http://orcid.org/0000-0003-3935-8803
AD  - Steadman Philippon Research Institute, Vail, Colorado.
AD  - The Steadman Clinic, Vail, Colorado.
FAU - Liebowitz, Andrea
AU  - Liebowitz A
AD  - Steadman Philippon Research Institute, Vail, Colorado.
FAU - Bolia, Ioanna K
AU  - Bolia IK
AD  - Steadman Philippon Research Institute, Vail, Colorado.
FAU - Chahla, Jorge
AU  - Chahla J
AD  - Steadman Philippon Research Institute, Vail, Colorado.
FAU - Ravuri, Sudheer
AU  - Ravuri S
AD  - Steadman Philippon Research Institute, Vail, Colorado.
FAU - Evans, Thos A
AU  - Evans TA
AD  - Steadman Philippon Research Institute, Vail, Colorado.
AD  - The Steadman Clinic, Vail, Colorado.
FAU - Philippon, Marc J
AU  - Philippon MJ
AD  - Steadman Philippon Research Institute, Vail, Colorado.
AD  - The Steadman Clinic, Vail, Colorado.
FAU - Huard, Johnny
AU  - Huard J
AD  - Steadman Philippon Research Institute, Vail, Colorado.
AD  - The University of Texas Health Science Center at Houston, Houston, Texas.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Cytokines)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Cytokines/*therapeutic use
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*therapeutic use
MH  - Osteoarthritis/*therapy
MH  - *Platelet-Rich Plasma
MH  - Regenerative Medicine/methods/trends
MH  - Stem Cell Transplantation/*methods/trends
MH  - Tissue Engineering/methods/trends
OTO - NOTNLM
OT  - growth factor and cytokine therapy
OT  - stem cell therapy
OT  - tissue engineering
EDAT- 2017/12/22 06:00
MHDA- 2018/01/10 06:00
CRDT- 2017/12/22 06:00
PHST- 2017/05/24 00:00 [received]
PHST- 2017/10/18 00:00 [revised]
PHST- 2017/10/25 00:00 [accepted]
PHST- 2017/12/22 06:00 [entrez]
PHST- 2017/12/22 06:00 [pubmed]
PHST- 2018/01/10 06:00 [medline]
AID - 10.1111/nyas.13554 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2017 Dec;1410(1):26-43. doi: 10.1111/nyas.13554.