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Role of nuclear factor-κB activation in sepsis-induced myocardial dysfunction.

Abstract As a common complication in patients with sepsis, cardiac dysfunction may significantly increase mortality of these patients, but its mechanism is still unclear. Nuclear factor-κB (NF-κB) is a pleiotropic transcription inducing factor, which involves in the regulation of multiple biological phenomena and disease status. NF-κB activation participates in cardiomyocyte apoptosis, cardiomyocyte autophagy, and release of inflammatory cytokines in patients with sepsis, indicating its important role in sepsis-induced myocardial dysfunction.
PMID
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Authors

Mayor MeshTerms
Keywords

Apoptosis

Autophagy

Cardiomyopathies

Inflammatory cytokine

NF-kappa B

Sepsis

Journal Title zhonghua shao shang za zhi = zhonghua shaoshang zazhi = chinese journal of burns
Publication Year Start




PMID- 29275619
OWN - NLM
STAT- In-Process
LR  - 20171225
IS  - 1009-2587 (Print)
IS  - 1009-2587 (Linking)
VI  - 33
IP  - 12
DP  - 2017 Dec 20
TI  - [Role of nuclear factor-kappaB activation in sepsis-induced myocardial
      dysfunction].
PG  - 782-784
LID - 10.3760/cma.j.issn.1009-2587.2017.12.014 [doi]
AB  - As a common complication in patients with sepsis, cardiac dysfunction may
      significantly increase mortality of these patients, but its mechanism is still
      unclear. Nuclear factor-kappaB (NF-kappaB) is a pleiotropic transcription
      inducing factor, which involves in the regulation of multiple biological
      phenomena and disease status. NF-kappaB activation participates in cardiomyocyte 
      apoptosis, cardiomyocyte autophagy, and release of inflammatory cytokines in
      patients with sepsis, indicating its important role in sepsis-induced myocardial 
      dysfunction.
FAU - Zhou, H
AU  - Zhou H
AD  - Department of Burn Surgery, Institute of Burns, Changhai Hospital, Naval Medical 
      University, Shanghai 200433, China.
FAU - Wang, G Q
AU  - Wang GQ
FAU - Luo, P F
AU  - Luo PF
FAU - Xia, Z F
AU  - Xia ZF
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Shao Shang Za Zhi
JT  - Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
JID - 100959418
OTO - NOTNLM
OT  - Apoptosis
OT  - Autophagy
OT  - Cardiomyopathies
OT  - Inflammatory cytokine
OT  - NF-kappa B
OT  - Sepsis
EDAT- 2017/12/26 06:00
MHDA- 2017/12/26 06:00
CRDT- 2017/12/26 06:00
PHST- 2017/12/26 06:00 [entrez]
PHST- 2017/12/26 06:00 [pubmed]
PHST- 2017/12/26 06:00 [medline]
PST - ppublish
SO  - Zhonghua Shao Shang Za Zhi. 2017 Dec 20;33(12):782-784.