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Should Adjuvant Radiation Therapy Be Systematically Proposed for Male Breast Cancer? A Systematic Review.

Abstract Guidelines for radiotherapy in male breast cancer (MBC) are lacking. Some extrapolate the results from female breast cancer trials, while others advocate systematic adjuvant irradiation. We evaluated clinical practices and outcomes with respect to radiation therapy in MBC treated with locoregional irradiation in the adjuvant setting using a systematic literature review.
PMID
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Authors

Mayor MeshTerms
Keywords

Male breast cancer

adjuvant treatment

local control

mastectomy

prognostic factors

radiotherapy

review

Journal Title anticancer research
Publication Year Start




PMID- 29277752
OWN - NLM
STAT- MEDLINE
DCOM- 20180101
LR  - 20180101
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - Should Adjuvant Radiation Therapy Be Systematically Proposed for Male Breast
      Cancer? A Systematic Review.
PG  - 23-31
AB  - BACKGROUND: Guidelines for radiotherapy in male breast cancer (MBC) are lacking. 
      Some extrapolate the results from female breast cancer trials, while others
      advocate systematic adjuvant irradiation. We evaluated clinical practices and
      outcomes with respect to radiation therapy in MBC treated with locoregional
      irradiation in the adjuvant setting using a systematic literature review.
      MATERIAL AND METHODS: We included studies with data about adjuvant radiotherapy
      published between 1984 and 2017 and including at least 40 patients. RESULTS: We
      found 29 retrospective series, 10,065 men were diagnosed with breast cancer;
      3-100% (mean=54%) received adjuvant radiotherapy. Tumor size and nodal
      involvement were the strongest prognostic factors. Approximatively half of all
      cases had nodal metastases. Radiation therapy improved locoregional control in
      six series, overall survival in three and distant metastasis-free survival in
      one. CONCLUSION: MBC is diagnosed at a highly advanced stage and may be linked
      with poorer outcomes. Adjuvant radiation therapy must, at least, be proposed to
      men with positive nodes. Despite the large number of cases gathered here,
      arguments for radiotherapy in other prognostic subgroups (especially in pN0) may 
      exist but are not well supported.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Jardel, Pauline
AU  - Jardel P
AD  - Department of Radiation Oncology, Chicoutimi Hospital, Saguenay, QC, Canada.
FAU - Vignot, Stephane
AU  - Vignot S
AD  - Department of Medical Oncology, Louis Pasteur Hospital, Le Coudray, France.
FAU - Cutuli, Bruno
AU  - Cutuli B
AD  - Department of Radiation Oncology, Courlancy Polyclinic, Reims, France.
FAU - Creisson, Anne
AU  - Creisson A
AD  - Department of Medical Oncology, Antoine Lacassagne Anticancer Center, Nice,
      France.
FAU - Vass, Sylvie
AU  - Vass S
AD  - Department of Radiation Oncology, Chicoutimi Hospital, Saguenay, QC, Canada.
FAU - Barranger, Emmanuel
AU  - Barranger E
AD  - Department of Surgery, Antoine Lacassagne Anticancer Center, Nice, France.
FAU - Thariat, Juliette
AU  - Thariat J
AD  - Department of Radiation Oncology, Francois Baclesse Anticancer Center, Caen,
      France [email protected]
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Breast Neoplasms, Male/*radiotherapy
MH  - Humans
MH  - Male
MH  - Radiotherapy, Adjuvant
OTO - NOTNLM
OT  - Male breast cancer
OT  - adjuvant treatment
OT  - local control
OT  - mastectomy
OT  - prognostic factors
OT  - radiotherapy
OT  - review
EDAT- 2017/12/27 06:00
MHDA- 2018/01/02 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/09/29 00:00 [received]
PHST- 2017/10/23 00:00 [revised]
PHST- 2017/10/27 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2018/01/02 06:00 [medline]
AID - 38/1/23 [pii]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):23-31.