PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Histone Deacetylase Inhibitors as a Novel Targeted Therapy Against Non-small Cell Lung Cancer: Where Are We Now and What Should We Expect?

Abstract Non-small cell lung cancer constitutes the most common type of lung cancer, accounting for 85-90% of lung cancer, and is a leading cause of cancer-related death. Despite the progress during the past years, poor prognosis remains a challenge and requires further research and development of novel antitumor treatment. Recently, the role of histone deacetylases in gene expression has emerged showing their regulation of the acetylation of histone proteins and other non-histone protein targets and their role in chromatin organization, while their inhibitors, the histone deacetylase inhibitors, have been proposed to have a potential therapeutic role in diverse malignancies, including non-small cell lung cancer. This review article focuses on the role of histone deacetylase inhibitors in the treatment of non-small cell lung cancer and the major molecular mechanisms underlying their antitumor activity recognized so far.
PMID
Related Publications

Histone deacetylase inhibitors in non-small-cell lung cancer.

A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer.

The potential role of histone deacetylase inhibitors in the treatment of non-small-cell lung cancer.

Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer.

Entinostat (SNDX-275) for the treatment of non-small cell lung cancer.

Authors

Mayor MeshTerms
Keywords

HDAC

Histone

cancer

deacetylase

epigenetics

inhibitor

lung

non-small cell

review

targeted

Journal Title anticancer research
Publication Year Start




PMID- 29277754
OWN - NLM
STAT- MEDLINE
DCOM- 20180101
LR  - 20180101
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - Histone Deacetylase Inhibitors as a Novel Targeted Therapy Against Non-small Cell
      Lung Cancer: Where Are We Now and What Should We Expect?
PG  - 37-43
AB  - Non-small cell lung cancer constitutes the most common type of lung cancer,
      accounting for 85-90% of lung cancer, and is a leading cause of cancer-related
      death. Despite the progress during the past years, poor prognosis remains a
      challenge and requires further research and development of novel antitumor
      treatment. Recently, the role of histone deacetylases in gene expression has
      emerged showing their regulation of the acetylation of histone proteins and other
      non-histone protein targets and their role in chromatin organization, while their
      inhibitors, the histone deacetylase inhibitors, have been proposed to have a
      potential therapeutic role in diverse malignancies, including non-small cell lung
      cancer. This review article focuses on the role of histone deacetylase inhibitors
      in the treatment of non-small cell lung cancer and the major molecular mechanisms
      underlying their antitumor activity recognized so far.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Damaskos, Christos
AU  - Damaskos C
AD  - Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School,
      National and Kapodistrian University of Athens, Athens, Greece
      [email protected]
AD  - N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical 
      School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Tomos, Ioannis
AU  - Tomos I
AD  - Second Pulmonary Medicine Department, Attikon University Hospital, National and
      Kapodistrian University of Athens, Athens, Greece.
FAU - Garmpis, Nikolaos
AU  - Garmpis N
AD  - Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School,
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Karakatsani, Anna
AU  - Karakatsani A
AD  - Second Pulmonary Medicine Department, Attikon University Hospital, National and
      Kapodistrian University of Athens, Athens, Greece.
FAU - Dimitroulis, Dimitrios
AU  - Dimitroulis D
AD  - Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School,
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Garmpi, Anna
AU  - Garmpi A
AD  - Internal Medicine Department, Laiko General Hospital, Medical School, National
      and Kapodistrian University of Athens, Athens, Greece.
FAU - Spartalis, Eleftherios
AU  - Spartalis E
AD  - N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical 
      School, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Kampolis, Christos F
AU  - Kampolis CF
AD  - Department of Pathophysiology, School of Medicine, National and Kapodistrian
      University of Athens, Athens, Greece.
FAU - Tsagkari, Eleni
AU  - Tsagkari E
AD  - Department of Thoracic Surgery, Attikon University Hospital, National and
      Kapodistrian University of Athens, Athens, Greece.
FAU - Loukeri, Angeliki A
AU  - Loukeri AA
AD  - Respiratory Care Unit, Sotiria Hospital, General Hospital of Chest Diseases,
      Athens, Greece.
FAU - Margonis, Georgios-Antonios
AU  - Margonis GA
AD  - Department of Surgery, The Johns Hopkins University School of Medicine,
      Baltimore, ML, U.S.A.
FAU - Spartalis, Michael
AU  - Spartalis M
AD  - Division of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Andreatos, Nikolaos
AU  - Andreatos N
AD  - Department of Surgery, The Johns Hopkins University School of Medicine,
      Baltimore, ML, U.S.A.
FAU - Schizas, Dimitrios
AU  - Schizas D
AD  - First Department of Surgery, Laiko General Hospital, Medical School, National and
      Kapodistrian University of Athens, Athens, Greece.
FAU - Kokkineli, Stefania
AU  - Kokkineli S
AD  - First Department of Surgery, Laiko General Hospital, Medical School, National and
      Kapodistrian University of Athens, Athens, Greece.
FAU - Antoniou, Efstathios A
AU  - Antoniou EA
AD  - Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School,
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Nonni, Afroditi
AU  - Nonni A
AD  - First Department of Pathology, School of Medicine, National and Kapodistrian
      University of Athens, Athens, Greece.
FAU - Tsourouflis, Gerasimos
AU  - Tsourouflis G
AD  - Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School,
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Markatos, Konstantinos
AU  - Markatos K
AD  - Biomedical Research Foundation (IIBEA), Academy of Athens, Athens, Greece.
FAU - Kontzoglou, Konstantinos
AU  - Kontzoglou K
AD  - Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School,
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Kostakis, Alkiviadis
AU  - Kostakis A
AD  - Biomedical Research Foundation (IIBEA), Academy of Athens, Athens, Greece.
FAU - Tomos, Periklis
AU  - Tomos P
AD  - Department of Thoracic Surgery, Attikon University Hospital, National and
      Kapodistrian University of Athens, Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Histone Deacetylase Inhibitors)
SB  - IM
MH  - Antineoplastic Agents/pharmacology/*therapeutic use
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy/enzymology
MH  - Histone Deacetylase Inhibitors/pharmacology/*therapeutic use
MH  - Humans
MH  - Lung Neoplasms/*drug therapy/enzymology
OTO - NOTNLM
OT  - HDAC
OT  - Histone
OT  - cancer
OT  - deacetylase
OT  - epigenetics
OT  - inhibitor
OT  - lung
OT  - non-small cell
OT  - review
OT  - targeted
EDAT- 2017/12/27 06:00
MHDA- 2018/01/02 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/09/24 00:00 [received]
PHST- 2017/10/23 00:00 [revised]
PHST- 2017/10/25 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2018/01/02 06:00 [medline]
AID - 38/1/37 [pii]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):37-43.