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PMID- 29277760
OWN - NLM
STAT- MEDLINE
DCOM- 20180101
LR  - 20180104
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - Chemopreventive Potential of In Vitro Fermented Raw and Roasted Hazelnuts in LT97
      Colon Adenoma Cells.
PG  - 83-93
AB  - BACKGROUND/AIM: Due to their unique composition of health-promoting compounds,
      the consumption of hazelnuts may contribute to the prevention of colon cancer.
      MATERIALS AND METHODS: Since hazelnuts are often consumed roasted, the impact of 
      different roasting conditions (RC1=140.6 degrees C/25 min, RC2=155.1 degrees C/20
      min and RC3=180.4 degrees C/21 min) on chemopreventive effects of in vitro
      fermented hazelnuts was analyzed in LT97 colon adenoma cells. RESULTS: FS (2.5%) 
      of raw and roasted hazelnuts reduced H2O2-induced DNA damage while 5% FS
      significantly induced gene expression of SOD2 (3.0-fold) and GSTP1 (2.1-fold).
      GPx1 mRNA levels were significantly decreased (0.6-fold) by FS (2.5%). The growth
      of LT97 cells was significantly reduced by hazelnut FS in a time- and
      dose-dependent manner. Hazelnut FS (5%) increased the numbers of early apoptotic 
      cells (9.6% on average) and caspase-3 activities (6.4-fold on average).
      CONCLUSION: These results indicate a chemopreventive potential of in vitro
      fermented hazelnuts which is largely unaffected by the roasting process.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Glei, Michael
AU  - Glei M
AD  - Friedrich Schiller University Jena, Institute of Nutrition, Department of
      Nutritional Toxicology, Jena, Germany.
AD  - Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD),
      Halle-Jena-Leipzig, Germany.
FAU - Fischer, Sonja
AU  - Fischer S
AD  - Friedrich Schiller University Jena, Institute of Nutrition, Department of
      Nutritional Toxicology, Jena, Germany.
FAU - Lamberty, Julia
AU  - Lamberty J
AD  - Friedrich Schiller University Jena, Institute of Nutrition, Department of
      Nutritional Toxicology, Jena, Germany.
FAU - Ludwig, Diana
AU  - Ludwig D
AD  - Friedrich Schiller University Jena, Institute of Nutrition, Department of
      Nutritional Toxicology, Jena, Germany.
FAU - Lorkowski, Stefan
AU  - Lorkowski S
AD  - Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD),
      Halle-Jena-Leipzig, Germany.
AD  - Friedrich Schiller University Jena, Institute of Nutrition, Department of
      Nutritional Biochemistry and Physiology, Jena, Germany.
FAU - Schlormann, Wiebke
AU  - Schlormann W
AD  - Friedrich Schiller University Jena, Institute of Nutrition, Department of
      Nutritional Toxicology, Jena, Germany [email protected]
AD  - Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD),
      Halle-Jena-Leipzig, Germany.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Plant Preparations)
RN  - 0 (RNA, Messenger)
RN  - 0 (SOD1 protein, human)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.11.1.- (glutathione peroxidase GPX1)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase-1)
RN  - EC 2.5.1.18 (GSTP1 protein, human)
RN  - EC 2.5.1.18 (Glutathione S-Transferase pi)
SB  - IM
MH  - Adenoma/*drug therapy/genetics/prevention & control
MH  - Anticarcinogenic Agents/*pharmacology
MH  - Antineoplastic Agents/*pharmacology
MH  - Apoptosis/drug effects
MH  - Catalase/genetics
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Colonic Neoplasms/*drug therapy/genetics/prevention & control
MH  - Cooking
MH  - *Corylus
MH  - DNA Damage/drug effects
MH  - Glutathione Peroxidase/genetics
MH  - Glutathione S-Transferase pi/genetics
MH  - Humans
MH  - Hydrogen Peroxide/toxicity
MH  - Nuts
MH  - Plant Preparations/*pharmacology
MH  - RNA, Messenger/metabolism
MH  - Superoxide Dismutase-1/genetics
OTO - NOTNLM
OT  - *Apoptosis
OT  - *colon cancer
OT  - *dietary fiber
OT  - *hazelnuts
EDAT- 2017/12/27 06:00
MHDA- 2018/01/02 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/10/27 00:00 [received]
PHST- 2017/11/10 00:00 [revised]
PHST- 2017/11/13 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2018/01/02 06:00 [medline]
AID - 38/1/83 [pii]
AID - 10.21873/anticanres.12195 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):83-93. doi: 10.21873/anticanres.12195.