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PMID- 29277766
DCOM- 20180101
LR  - 20180104
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - Manganese Inhibits Viability of Prostate Cancer Cells.
PG  - 137-145
AB  - BACKGROUND/AIM: Androgen deprivation therapy is usually in the initial phase a
      successful treatment for prostate cancer but eventually most patients develop
      androgen-independent metastatic disease. This study investigated if manganese
      (Mn) reduces viability of prostate cancer via induction of apoptosis. MATERIALS
      AND METHODS: The prostate cancer cell lines PC3, DU145 and LNCaP underwent dose- 
      and time-dependent screening of viability, analyzed by the
      3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay. Flow
      cytometry was used for the cell-cycle and apoptosis analyses. Intracellular Mn
      concentration was measured using inductively coupled plasma-mass spectrometry.
      RESULTS: At Mn concentrations of 200-1000 muM, the effect on viability was most
      pronounced in PC3 followed by LNCaP cells. These cell lines also showed higher
      intracellular concentration of Mn compared to DU145. In all cell lines, Mn
      increased the proportion of cells arrested in the G0/G1 phase and induced
      apoptosis. CONCLUSION: To our knowledge, this is the first report demonstrating
      Mn as a potential agent in prostate cancer therapy.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Hernroth, Bodil
AU  - Hernroth B
AD  - Department of Natural Science, Kristianstad University, Kristianstad, Sweden.
AD  - The Royal Swedish Academy of Sciences, Fiskebackskil, Sweden.
FAU - Holm, Ingvar
AU  - Holm I
AD  - Department of Natural Science, Kristianstad University, Kristianstad, Sweden.
FAU - Gondikas, Andreas
AU  - Gondikas A
AD  - Department of Marine Sciences, University of Gothenburg, Goteborg, Sweden.
FAU - Tassidis, Helena
AU  - Tassidis H
AD  - Department of Natural Science, Kristianstad University, Kristianstad, Sweden
      [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Antineoplastic Agents)
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - Apoptosis/drug effects
MH  - Cell Cycle/drug effects
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Humans
MH  - Male
MH  - Manganese/*pharmacology
MH  - Prostatic Neoplasms/*drug therapy
OT  - *DU145
OT  - *LNCaP
OT  - *Manganese
OT  - *PC3
OT  - *apoptosis
OT  - *cell viability
OT  - *prostate cancer
EDAT- 2017/12/27 06:00
MHDA- 2018/01/02 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/10/13 00:00 [received]
PHST- 2017/11/06 00:00 [revised]
PHST- 2017/11/08 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2018/01/02 06:00 [medline]
AID - 38/1/137 [pii]
AID - 10.21873/anticanres.12201 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):137-145. doi: 10.21873/anticanres.12201.