PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 29277772
OWN - NLM
STAT- In-Process
LR  - 20171226
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - Deregulation of Nicotinamide N-Methyltransferase and Gap Junction Protein Alpha-1
      Causes Metastasis in Adenoid Cystic Carcinoma.
PG  - 187-197
AB  - BACKGROUND/AIM: Adenoid cystic carcinoma (AdCC) is a malignant tumor that occurs 
      in the salivary glands and frequently metastasizes. The aim of this study was to 
      identify factors mediating AdCC metastasis. MATERIALS AND METHODS: We established
      three AdCC cell lines by orthotropic transplantation and in vivo selection:
      parental, highly metastatic (ACCS-M-GFP), and lymph node metastatic (ACCS-LN-GFP)
      cells. RESULTS: We examined the three cell lines. DNA microarray indicated
      significantly altered processes in ACCS-LN-GFP cells: particularly, the
      expression of nicotinamide N-methyltransferase (NNMT) was enhanced the most. NNMT
      is associated with tumorigenesis and is a potential tumor biomarker.
      Concomitantly, we found-significant down-regulation of gap junction protein
      alpha-1. We suggest that ACCS-LN-GFP cells acquire cancer stem cell features
      involving the up-regulation of NNMT and the loss of gap junction protein alpha-1,
      leading to epithelial-mesenchymal transition and consequent AdCC metastasis.
      CONCLUSION: NNMT is a potential biomarker of AdCC.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Ishibashi, Kana
AU  - Ishibashi K
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
FAU - Ishii, Kotaro
AU  - Ishii K
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
      [email protected]
FAU - Sugiyama, Goro
AU  - Sugiyama G
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
FAU - Sumida, Tomoki
AU  - Sumida T
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
FAU - Sugiura, Tsuyoshi
AU  - Sugiura T
AD  - Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and
      Maxillofacial Rehabilitation, Graduate School of Dental Science, Kagoshima
      University, Kagoshima, Japan.
FAU - Kamata, Y U
AU  - Kamata YU
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
FAU - Seki, Katsuhiro
AU  - Seki K
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
FAU - Fujinaga, Takahiro
AU  - Fujinaga T
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
FAU - Kumamaru, Wataru
AU  - Kumamaru W
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
FAU - Kobayashi, Yosuke
AU  - Kobayashi Y
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
FAU - Hiyake, Naomi
AU  - Hiyake N
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
FAU - Nakano, Hiroyuki
AU  - Nakano H
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
FAU - Yamada, Tomohiro
AU  - Yamada T
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
FAU - Mori, Yoshihide
AU  - Mori Y
AD  - Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and
      Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
OTO - NOTNLM
OT  - Adenoid cystic carcinoma
OT  - epithelial-mesenchymal transition
OT  - metastatic cell lines
OT  - nicotinamide N-methyltransferase
OT  - primary tumor cell lines
EDAT- 2017/12/27 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/10/06 00:00 [received]
PHST- 2017/10/22 00:00 [revised]
PHST- 2017/10/23 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - 38/1/187 [pii]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):187-197.