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Carvacrol Targets AXL to Inhibit Cell Proliferation and Migration in Non-small Cell Lung Cancer Cells.

Abstract AXL has been reported to be overexpressed and highly activated in various cancer types. In this study, we demonstrated the effect of carvacrol on cell proliferation and migration in non-small cell lung cancer (NSCLC) cells by impeding the expression and activation of AXL.
PMID
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Authors

Mayor MeshTerms
Keywords

AXL

NSCLC

carvacrol

migration

proliferation

Journal Title anticancer research
Publication Year Start




PMID- 29277784
OWN - NLM
STAT- In-Process
LR  - 20171226
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - Carvacrol Targets AXL to Inhibit Cell Proliferation and Migration in Non-small
      Cell Lung Cancer Cells.
PG  - 279-286
AB  - BACKGROUND/AIM: AXL has been reported to be overexpressed and highly activated in
      various cancer types. In this study, we demonstrated the effect of carvacrol on
      cell proliferation and migration in non-small cell lung cancer (NSCLC) cells by
      impeding the expression and activation of AXL. MATERIALS AND METHODS: The levels 
      of AXL protein, mRNA and promoter activity were evaluated by western blot,
      reverse transcription polymerase chain reaction (RT-PCR) and luciferase assay,
      respectively. AXL-overexpressing cells were established by ectopic expression of 
      AXL cDNA. Cell viability, clonogenicity, and migration were measured in
      carvacrol-treated NSCLC cells. RESULTS: Carvacrol treatment of NSCLC cells caused
      down-regulation of AXL expression at the transcriptional level and also inhibited
      phosphorylation of AXL upon ligand stimulation. Carvacrol suppressed cell
      proliferation and migration and its inhibitory effect was attenuated in
      AXL-overexpressing NSCLC cells. CONCLUSION: Our data demonstrate that AXL is a
      crucial therapeutic target of carvacrol-induced inhibition of NSCLC cell
      proliferation and migration.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Jung, Chi Young
AU  - Jung CY
AD  - Department of Internal Medicine, College of Medicine, Catholic University of
      Daegu, Daegu, Republic of Korea.
FAU - Kim, So-Young
AU  - Kim SY
AD  - Department of Pharmacology, School of Medicine, Dongguk University, Gyeongju,
      Republic of Korea.
FAU - Lee, Chuhee
AU  - Lee C
AD  - Department of Biochemistry and Molecular Biology, School of Medicine, Yeungnam
      University, Daegu, Republic of Korea [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
OTO - NOTNLM
OT  - AXL
OT  - NSCLC
OT  - carvacrol
OT  - migration
OT  - proliferation
EDAT- 2017/12/27 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/10/17 00:00 [received]
PHST- 2017/11/02 00:00 [revised]
PHST- 2017/11/08 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - 38/1/279 [pii]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):279-286.