PubTransformer

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PMID- 29277788
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20180105
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - A Mouse Model for Oral Mucositis Induced by Cancer Chemotherapy.
PG  - 307-312
AB  - BACKGROUND: Oral mucositis (OM), one of the side-effects induced by chemotherapy,
      has 40% incidence and the incidence rate increases to approximately 100% in
      combination with radiotherapy. We describe OM in ICR mice induced using
      5-fluorouracil (5-FU) and 20% acetic acid. MATERIALS AND METHODS: We optimized
      the dose of 5-FU and 20% acetic acid and validated the efficacy of standard
      therapies for OM. RESULTS: All mice developed OM after administration of 5-FU and
      20% acetic acid. Application of Kenalog(R) reduced maximum ulcer area and the
      duration of spontaneous recovery in a dose-dependent manner. CONCLUSION: We
      succeeded in developing a mouse model of OM induced by cancer chemotherapy. New
      drugs for OM induced by anticancer drugs can be evaluated simply by monitoring
      the WBC count in this mouse model. This model is expected to contribute to
      development of new drugs and elucidation of the mechanisms of ameliorating
      stomatitis as a side-effect of anticancer drugs.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Shimamura, Yosuke
AU  - Shimamura Y
AD  - Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
FAU - Takeuchi, Issei
AU  - Takeuchi I
AD  - Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
FAU - Terada, Hiroshi
AU  - Terada H
AD  - Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
AD  - Tokyo University of Science Center for Drug Delivery Research, Tokyo University
      of Science, Chiba, Japan.
AD  - Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
FAU - Makino, Kimiko
AU  - Makino K
AD  - Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan
      [email protected]
AD  - Tokyo University of Science Center for Drug Delivery Research, Tokyo University
      of Science, Chiba, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antineoplastic Agents)
RN  - F446C597KA (Triamcinolone Acetonide)
RN  - Q40Q9N063P (Acetic Acid)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Acetic Acid/*adverse effects
MH  - Animals
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Antineoplastic Agents/*adverse effects
MH  - *Disease Models, Animal
MH  - Fluorouracil/*adverse effects
MH  - Male
MH  - Mice, Inbred ICR
MH  - Stomatitis/*chemically induced/drug therapy
MH  - Triamcinolone Acetonide/therapeutic use
OTO - NOTNLM
OT  - *Oral mucositis
OT  - *chemotherapy
OT  - *mouse model
EDAT- 2017/12/27 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/09/10 00:00 [received]
PHST- 2017/11/06 00:00 [revised]
PHST- 2017/11/07 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
AID - 38/1/307 [pii]
AID - 10.21873/anticanres.12223 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):307-312. doi: 10.21873/anticanres.12223.