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PMID- 29277792
OWN - NLM
STAT- In-Process
LR  - 20171226
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - Neoadjuvant Chemotherapy with Gemcitabine Plus Nab-paclitaxel Reduces the Number 
      of Cancer-associated Fibroblasts Through Depletion of Pancreatic Stroma.
PG  - 337-343
AB  - BACKGROUND: In this study, the effects of neoadjuvant chemotherapy (NAC) on
      cancer-associated fibroblasts (CAFs) in pancreatic cancer stroma were
      investigated. MATERIALS AND METHODS: Density of alpha-smooth muscle actin
      (alphaSMA)-positive fibroblasts in resected surgical specimens from untreated
      patients, patients receiving conventional gemcitabine plus S-1 (GS), and patients
      receiving gemcitabine plus nab-paclitaxel (GnP) was determined by hybrid cell
      counting. 18F-Fluorodeoxyglucose positron-emission tomography (FDG-PET) scans and
      carbohydrate antigen 19-9 (CA19-9) concentrations were used to assess tumor
      activity before and after chemotherapy in the GnP group. RESULTS: In this
      retrospective study of 65 patients, alphaSMA expression was reduced in the GnP
      group, as revealed by markedly disorganized collagen and a low density of
      alphaSMA-positive fibroblasts. There were significantly fewer alphaSMA-positive
      fibroblasts in the GnP than in the untreated and GS groups, but there was no
      significant difference between the latter two groups. alphaSMA density reflected 
      a decrease in standardized uptake value on FDG-PET, but not CA19-9 concentration,
      after GnP chemotherapy. CONCLUSION: These data suggest that the GnP regimen
      induces stromal depletion, resulting in fewer CAFs.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Miyashita, Tomoharu
AU  - Miyashita T
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan [email protected]
FAU - Tajima, Hidehiro
AU  - Tajima H
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan.
FAU - Makino, Isamu
AU  - Makino I
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan.
FAU - Okazaki, Mitsuyoshi
AU  - Okazaki M
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan.
FAU - Yamaguchi, Takahisa
AU  - Yamaguchi T
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan.
FAU - Ohbatake, Yoshinao
AU  - Ohbatake Y
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan.
FAU - Nakanuma, Sinichi
AU  - Nakanuma S
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan.
FAU - Hayashi, Hironori
AU  - Hayashi H
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan.
FAU - Takamura, Hiroyuki
AU  - Takamura H
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan.
FAU - Ninomiya, Itasu
AU  - Ninomiya I
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan.
FAU - Fushida, Sachio
AU  - Fushida S
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan.
FAU - Kishimoto, Koji
AU  - Kishimoto K
AD  - Graduate School of Technology, Industrial and Social Sciences, Bioscience and
      Bioindustry, Food Science and Technology, Tokushima University, Tokushima, Japan.
FAU - Harmon, John W
AU  - Harmon JW
AD  - Department of Surgery, Johns Hopkins University School of Medicine, Baltimore,
      MD, U.S.A.
FAU - Ohta, Tetsuo
AU  - Ohta T
AD  - Department of Gastroenterological Surgery, Kanazawa University Hospital,
      Kanazawa, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
OTO - NOTNLM
OT  - Pancreatic cancer
OT  - cancer-associated fibroblast
OT  - chemoresistance
OT  - stroma
OT  - tumor microenvironment
EDAT- 2017/12/27 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/10/12 00:00 [received]
PHST- 2017/11/03 00:00 [revised]
PHST- 2017/11/07 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - 38/1/337 [pii]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):337-343.