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Computed Tomography Density Change in the Thyroid Gland Before and After Radiation Therapy.

Abstract Hypothyroidism is an established adverse effect of radiation therapy for head and neck cancer, and computed tomography (CT) density of the thyroid gland is lower in hypothyroid than euthyroid individuals. No previous studies have evaluated changes in CT densities of the thyroid gland caused by radiation therapy. The aim was to investigate the relationship between the change in CT density of the thyroid gland before and after radiation therapy for head and neck cancer and hypothyroidism.
PMID
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Authors

Mayor MeshTerms
Keywords

CT density change

head and neck cancer

radiation therapy

thyroid function

thyroid gland

Journal Title anticancer research
Publication Year Start




PMID- 29277803
OWN - NLM
STAT- In-Process
LR  - 20180104
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - Computed Tomography Density Change in the Thyroid Gland Before and After
      Radiation Therapy.
PG  - 417-421
AB  - BACKGROUND/AIM: Hypothyroidism is an established adverse effect of radiation
      therapy for head and neck cancer, and computed tomography (CT) density of the
      thyroid gland is lower in hypothyroid than euthyroid individuals. No previous
      studies have evaluated changes in CT densities of the thyroid gland caused by
      radiation therapy. The aim was to investigate the relationship between the change
      in CT density of the thyroid gland before and after radiation therapy for head
      and neck cancer and hypothyroidism. MATERIALS AND METHODS: This retrospective
      study analyzed data of 24 patients treated by radiation therapy for head and neck
      cancers. After dosimetric analysis of received radiation therapy, a Picture
      Archiving and Communication System was used to manually contour the thyroid on
      pre-treatment CT images to enable determination of mean thyroid gland CT
      densities and received radiation doses. Pre- and post-treatment thyroid function 
      was assessed on the basis of serum TSH concentrations. Multivariate and
      univariate analyses were used to determine what clinical factors are associated
      with post-radiation therapy decrease in CT density of the thyroid and Pearson's
      chi(2) test was used to assess correlations between these densities and TSH
      concentrations. RESULTS: Mean CT densities of the thyroid gland decreased from
      before to after radiation therapy in 73.9% of our patients (median decrease 16.8 
      HU). Serum TSH concentrations were significantly higher in patients with greater 
      then median decreases in CT density than in those with lesser or no decreases.
      CONCLUSION: Post-radiation therapy hypothyroidism may be predicted by significant
      decreases in CT density of the thyroid gland.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Ishibashi, Naoya
AU  - Ishibashi N
AD  - Department of Radiology, Nihon University School of Medicine, Tokyo, Japan
      [email protected]
FAU - Maebayashi, Toshiya
AU  - Maebayashi T
AD  - Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
FAU - Aizawa, Takuya
AU  - Aizawa T
AD  - Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
FAU - Sakaguchi, Masakuni
AU  - Sakaguchi M
AD  - Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
FAU - Okada, Masahiro
AU  - Okada M
AD  - Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
FAU - Matsushita, Junichi
AU  - Matsushita J
AD  - Department of Radiological Technology, Nihon University School of Medicine,
      Tokyo, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
OTO - NOTNLM
OT  - *CT density change
OT  - *head and neck cancer
OT  - *radiation therapy
OT  - *thyroid function
OT  - *thyroid gland
EDAT- 2017/12/27 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/10/27 00:00 [received]
PHST- 2017/11/15 00:00 [revised]
PHST- 2017/11/17 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - 38/1/417 [pii]
AID - 10.21873/anticanres.12238 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):417-421. doi: 10.21873/anticanres.12238.