PubTransformer

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PMID- 29277805
OWN - NLM
STAT- In-Process
LR  - 20171226
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - Is There a Role for Functional MRI for the Assessment of Extracapsular Extension 
      in Prostate Cancer?
PG  - 427-432
AB  - BACKGROUND/AIM: Exctracapsular extension (ECE) in prostate cancer has a high
      impact on treatment decision. MRI might predict presence of ECE non-invasively.
      PATIENTS AND METHODS: Triplanar T2w-sequences, DWI (diffusion weighted imaging)
      and DCE (dynamic contrast-enhanced imaging) of 34 patients with PCa were analyzed
      to prior prostatectomy. Sensitivity (SS) and specificity (SP) of T2w, apparent
      diffusion coefficient (ADC), plasma flow (PF) and mean transit time (MTT)
      normalized by PCa/normal tissue ratio for prediction of CI (capsular
      infiltration)/ECE were determined by
      area-under-the-receiver-operating-characteristics analysis. RESULTS: SS/SP for
      detecting ECE was 29/85. AUC (area under the curve) of ECE cases was
      0.98/0.92/0.69 (cut-off-ratios 3.2/0.51/0.46), SS 93/100/86% and SP 95/80/50% for
      PF-/MTT-/ADC-ratios, respectively. PF- and MTT-ratios between CI and without
      CI/ECE differed significantly (PF, p<0.0001; MTT, p=0.0134) with SS/SP 84/89% for
      PF and SS/SP 52/100% for MTT-ratios. No significant differences regarding
      ADC-ratios were identified. CONCLUSION: ECE/CI can be assessed by quantitative
      DCE analysis with great diagnostic confidence and higher specificity than ADC.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Sertdemir, Metin
AU  - Sertdemir M
AD  - Diagnostische Gemeinschaftspraxis, Karlsruhe, Germany.
FAU - Weidner, Anja M
AU  - Weidner AM
AD  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center
      Mannheim, Mannheim, Germany [email protected]
FAU - Schoenberg, Stefan O
AU  - Schoenberg SO
AD  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center
      Mannheim, Mannheim, Germany.
FAU - Morelli, John N
AU  - Morelli JN
AD  - Department of Radiology, St. John's Medical Center, Tulsa, OK, U.S.A.
FAU - Haecker, Axel
AU  - Haecker A
AD  - Department of Urology, University Medical Center Mannheim, Mannheim, Germany.
FAU - Kirchner, Matthias
AU  - Kirchner M
AD  - Institute of Pathology, University Medical Center Mannheim, Mannheim, Germany.
FAU - Weiss, Christel
AU  - Weiss C
AD  - Department of Biostatistics, University Medical Center Mannheim, Mannheim,
      Germany.
FAU - Hausmann, Daniel
AU  - Hausmann D
AD  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center
      Mannheim, Mannheim, Germany.
FAU - Dinter, Dietmar J
AU  - Dinter DJ
AD  - Radiologie Schwetzingen, Schwetzingen, Germany.
FAU - Attenberger, Ulrike I
AU  - Attenberger UI
AD  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center
      Mannheim, Mannheim, Germany.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
OTO - NOTNLM
OT  - Magnetic resonance imaging
OT  - diffusion weighted MRI
OT  - dynamic contrast-enhanced MRI
OT  - extracapsular extension
OT  - prostate cancer
EDAT- 2017/12/27 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/10/16 00:00 [received]
PHST- 2017/11/06 00:00 [revised]
PHST- 2017/11/08 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - 38/1/427 [pii]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):427-432.