PubTransformer

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PMID- 29277823
OWN - NLM
STAT- In-Process
LR  - 20171226
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - Clinical Significance of PD-L1 Expression in Brain Metastases from Non-small Cell
      Lung Cancer.
PG  - 553-557
AB  - AIM: To investigate the association between positivity for programmed cell
      death-ligand 1 (PD-L1) in brain metastases (BM) and the prognosis or clinical
      factors in patients with non-small cell lung cancer (NSCLC). MATERIALS AND
      METHODS: Thirty-two patients with surgically resected brain-metastatic NSCLC were
      enrolled. The PD-L1 expression in BM was analyzed using the antibody against
      human PD-L1 (clone SP142). The PD-L1 positivity was defined as PD-L1 expression
      on brain-metastatic tumor cells of >/=5%. RESULTS: Seven (21.9%) out of 32
      patients showed PD-L1 positivity in BM. The PD-L1-positive BM group had a
      significantly shorter brain-specific disease-free survival than the
      PD-L1-negative BM group (p<0.05). PD-L1 positivity in BM was significantly
      associated with a heavy smoking history and the administration of radiotherapy
      for BM before surgery (p<0.05 and p<0.05, respectively). CONCLUSION: The PD-L1
      expression in BM from NSCLC may be associated with local recurrence following
      surgery, and the smoking- or radiotherapy-derived effects.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Takamori, Shinkichi
AU  - Takamori S
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
FAU - Toyokawa, Gouji
AU  - Toyokawa G
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan [email protected]
FAU - Okamoto, Isamu
AU  - Okamoto I
AD  - Research Institute for Disease of the Chest, Graduate School of Medical Sciences,
      Kyushu University, Higashi, Fukuoka, Japan.
FAU - Takada, Kazuki
AU  - Takada K
AD  - Department of Thoracic Oncology, National Kyushu Cancer Center, Minami, Fukuoka, 
      Japan.
FAU - Kinoshita, Fumihiko
AU  - Kinoshita F
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
FAU - Kozuma, Yuka
AU  - Kozuma Y
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
FAU - Matsubara, Taichi
AU  - Matsubara T
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
FAU - Haratake, Naoki
AU  - Haratake N
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
FAU - Akamine, Takaki
AU  - Akamine T
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
FAU - Mukae, Nobutaka
AU  - Mukae N
AD  - Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
FAU - Hirai, Fumihiko
AU  - Hirai F
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
FAU - Tagawa, Tetsuzo
AU  - Tagawa T
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
FAU - Oda, Yoshinao
AU  - Oda Y
AD  - Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
FAU - Iwaki, Toru
AU  - Iwaki T
AD  - Department of Neuropathology, Neurological Institute, Graduate School of Medical 
      Sciences, Kyushu University, Higashi, Fukuoka, Japan.
FAU - Iihara, Koji
AU  - Iihara K
AD  - Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
FAU - Nakanishi, Yoichi
AU  - Nakanishi Y
AD  - Research Institute for Disease of the Chest, Graduate School of Medical Sciences,
      Kyushu University, Higashi, Fukuoka, Japan.
FAU - Maehara, Yoshihiko
AU  - Maehara Y
AD  - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu
      University, Higashi, Fukuoka, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
OTO - NOTNLM
OT  - Programmed cell death-ligand 1
OT  - brain metastasis
OT  - non-small cell lung cancer
OT  - prognosis
EDAT- 2017/12/27 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/10/24 00:00 [received]
PHST- 2017/11/09 00:00 [revised]
PHST- 2017/11/13 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - 38/1/553 [pii]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):553-557.