PubTransformer

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PMID- 29277825
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20180104
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Jan
TI  - Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of
      Unknown Primary.
PG  - 565-567
AB  - BACKGROUND/AIM: The use of stereotactic radiosurgery (SRS) alone has become
      popular for treating patients with a limited number of brain metastases. In very 
      few patients, the primary tumor leading to cerebral spread is unknown. This study
      investigated the role of SRS for this rare situation. PATIENTS AND METHODS: Eight
      patients with 1-2 brain metastases from cancer of unknown primary (CUP) received 
      SRS alone (median dose 20 Gy). Five clinical factors were evaluated for
      association with local control of the irradiated lesions, freedom from new
      cerebral lesions and survival. RESULTS: Six-month and 12-month survival rates
      were 63% and 63%, respectively. Improved survival was associated with male gender
      and only one cerebral lesion. Local control rates at 6 and 12 months were 100%.
      Six-month rate of freedom from new cerebral lesions was 86%. CONCLUSION: SRS
      appeared effective and resulted in promising local control and survival rates in 
      patients with 1-2 brain metastases from CUP.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Dziggel, Liesa
AU  - Dziggel L
AD  - Department of Radiation Oncology, University of Lubeck, Lubeck, Germany.
FAU - Bajrovic, Amira
AU  - Bajrovic A
AD  - Department of Radiotherapy, University Medical Center Eppendorf, Hamburg,
      Germany.
FAU - Schild, Steven E
AU  - Schild SE
AD  - Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.
FAU - Rades, Dirk
AU  - Rades D
AD  - Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
      [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Brain Neoplasms/*radiotherapy/*secondary
MH  - Cranial Irradiation/adverse effects/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Unknown Primary/*pathology
MH  - Radiosurgery/adverse effects/*methods
MH  - Survival Rate
MH  - Treatment Outcome
OTO - NOTNLM
OT  - *Cancer of unknown primary
OT  - *brain metastases
OT  - *freedom from new cerebral lesions
OT  - *local control
OT  - *stereotactic radiosurgery
OT  - *survival
EDAT- 2017/12/27 06:00
MHDA- 2018/01/05 06:00
CRDT- 2017/12/27 06:00
PHST- 2017/10/30 00:00 [received]
PHST- 2017/11/15 00:00 [revised]
PHST- 2017/11/16 00:00 [accepted]
PHST- 2017/12/27 06:00 [entrez]
PHST- 2017/12/27 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
AID - 38/1/565 [pii]
AID - 10.21873/anticanres.12260 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Jan;38(1):565-567. doi: 10.21873/anticanres.12260.