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Circulating and broncho-alveolar interleukin-6 in relation to body temperature in an experimental model of bovine Chlamydia psittaci infection.

Abstract In rodent models of experimentally induced fever, the important role of interleukin-6 (IL-6) as a circulating endogenous pyrogen is well established. Studies employing larger animal species and real infections are scarce. Therefore, we assessed bioactive IL-6 in peripheral blood and in broncho-alveolar lavage fluid (BALF) of calves after intra-bronchial inoculation with vital Chlamydia psittaci (Cp), with inactivated Cp, or with BGM cells. Only calves inoculated with vital Cp developed fever (peak at 2-3 days after challenge) and significantly increased IL-6 activity. Controls inoculated with either inactivated Cp or BGM cells also expressed increased bioactive IL-6, but no fever developed. Activity of IL-6 in BALF was significantly higher compared to blood serum. This experimental model of Cp infection revealed no apparent relation between IL-6 in blood and body temperature, but did reveal a relation between IL-6 and other markers of inflammation in BALF. We conclude that a local inflammatory response in the lungs of infected calves caused fever, which developed by mechanisms including other mediators besides IL-6.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos one
Publication Year Start




PMID- 29281663
OWN - NLM
STAT- In-Data-Review
LR  - 20171227
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 12
DP  - 2017
TI  - Circulating and broncho-alveolar interleukin-6 in relation to body temperature in
      an experimental model of bovine Chlamydia psittaci infection.
PG  - e0189321
LID - 10.1371/journal.pone.0189321 [doi]
AB  - In rodent models of experimentally induced fever, the important role of
      interleukin-6 (IL-6) as a circulating endogenous pyrogen is well established.
      Studies employing larger animal species and real infections are scarce.
      Therefore, we assessed bioactive IL-6 in peripheral blood and in broncho-alveolar
      lavage fluid (BALF) of calves after intra-bronchial inoculation with vital
      Chlamydia psittaci (Cp), with inactivated Cp, or with BGM cells. Only calves
      inoculated with vital Cp developed fever (peak at 2-3 days after challenge) and
      significantly increased IL-6 activity. Controls inoculated with either
      inactivated Cp or BGM cells also expressed increased bioactive IL-6, but no fever
      developed. Activity of IL-6 in BALF was significantly higher compared to blood
      serum. This experimental model of Cp infection revealed no apparent relation
      between IL-6 in blood and body temperature, but did reveal a relation between
      IL-6 and other markers of inflammation in BALF. We conclude that a local
      inflammatory response in the lungs of infected calves caused fever, which
      developed by mechanisms including other mediators besides IL-6.
FAU - Prohl, Annette
AU  - Prohl A
AD  - Institute of Molecular Pathogenesis at 'Friedrich-Loeffler-Institut' (Federal
      Research Institute for Animal Health), Jena, Germany.
FAU - Ostermann, Carola H
AU  - Ostermann CH
AD  - Institute of Molecular Pathogenesis at 'Friedrich-Loeffler-Institut' (Federal
      Research Institute for Animal Health), Jena, Germany.
FAU - Rummel, Christoph D
AU  - Rummel CD
AD  - Institute of Veterinary Physiology and Biochemistry, Justus-Liebig-University
      Giessen, Germany.
FAU - Roth, Joachim
AU  - Roth J
AD  - Institute of Veterinary Physiology and Biochemistry, Justus-Liebig-University
      Giessen, Germany.
FAU - Reinhold, Petra
AU  - Reinhold P
AUID- ORCID: http://orcid.org/0000-0002-8310-2170
AD  - Institute of Molecular Pathogenesis at 'Friedrich-Loeffler-Institut' (Federal
      Research Institute for Animal Health), Jena, Germany.
LA  - eng
PT  - Journal Article
DEP - 20171227
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
EDAT- 2017/12/28 06:00
MHDA- 2017/12/28 06:00
CRDT- 2017/12/28 06:00
PHST- 2017/09/25 00:00 [received]
PHST- 2017/11/22 00:00 [accepted]
PHST- 2017/12/28 06:00 [entrez]
PHST- 2017/12/28 06:00 [pubmed]
PHST- 2017/12/28 06:00 [medline]
AID - 10.1371/journal.pone.0189321 [doi]
AID - PONE-D-17-34669 [pii]
PST - epublish
SO  - PLoS One. 2017 Dec 27;12(12):e0189321. doi: 10.1371/journal.pone.0189321.
      eCollection 2017.