PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Correlations between specific patterns of spontaneous activity and stimulation efficiency in degenerated retina.

Abstract Retinal prostheses that are currently used to restore vision in patients suffering from retinal degeneration are not adjusted to the changes occurring during the remodeling process of the retina. Recent studies revealed abnormal rhythmic activity in the retina of genetic mouse models of retinitis pigmentosa. Here we describe this abnormal activity also in a pharmacologically-induced (MNU) mouse model of retinal degeneration. To investigate how this abnormal activity affects the excitability of retinal ganglion cells, we recorded the electrical activity from whole mounted retinas of rd10 mice and MNU-treated mice using a microelectrode array system and applied biphasic current pulses of different amplitude and duration to stimulate ganglion cells electrically. We show that the electrical stimulation efficiency is strongly reduced in degenerated retinas, in particular when abnormal activity such as oscillations and rhythmic firing of bursts of action potentials can be observed. Using a prestimulus pulse sequence, we could abolish rhythmic retinal activity. Under these conditions, the stimulation efficiency was enhanced in a few cases but not in the majority of tested cells. Nevertheless, this approach supports the idea that modified stimulation protocols could help to improve the efficiency of retinal prostheses in the future.
PMID
Related Publications

Rhythmic ganglion cell activity in bleached and blind adult mouse retinas.

Degeneration stage-specific response pattern of retinal ganglion cell spikes in rd10 mouse retina.

Subretinal electrical stimulation reveals intact network activity in the blind mouse retina.

Comparison of electrical stimulation thresholds in normal and retinal degenerated mouse retina.

Decoding of temporal visual information from electrically evoked retinal ganglion cell activities in photoreceptor-degenerated retinas.

Authors

Mayor MeshTerms

Disease Models, Animal

Keywords
Journal Title plos one
Publication Year Start




PMID- 29281713
OWN - NLM
STAT- MEDLINE
DCOM- 20180206
LR  - 20180206
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 12
DP  - 2017
TI  - Correlations between specific patterns of spontaneous activity and stimulation
      efficiency in degenerated retina.
PG  - e0190048
LID - 10.1371/journal.pone.0190048 [doi]
AB  - Retinal prostheses that are currently used to restore vision in patients
      suffering from retinal degeneration are not adjusted to the changes occurring
      during the remodeling process of the retina. Recent studies revealed abnormal
      rhythmic activity in the retina of genetic mouse models of retinitis pigmentosa. 
      Here we describe this abnormal activity also in a pharmacologically-induced (MNU)
      mouse model of retinal degeneration. To investigate how this abnormal activity
      affects the excitability of retinal ganglion cells, we recorded the electrical
      activity from whole mounted retinas of rd10 mice and MNU-treated mice using a
      microelectrode array system and applied biphasic current pulses of different
      amplitude and duration to stimulate ganglion cells electrically. We show that the
      electrical stimulation efficiency is strongly reduced in degenerated retinas, in 
      particular when abnormal activity such as oscillations and rhythmic firing of
      bursts of action potentials can be observed. Using a prestimulus pulse sequence, 
      we could abolish rhythmic retinal activity. Under these conditions, the
      stimulation efficiency was enhanced in a few cases but not in the majority of
      tested cells. Nevertheless, this approach supports the idea that modified
      stimulation protocols could help to improve the efficiency of retinal prostheses 
      in the future.
FAU - Haselier, Christine
AU  - Haselier C
AD  - Department of Ophthalmology, RWTH Aachen University, Aachen, Germany.
FAU - Biswas, Sonia
AU  - Biswas S
AD  - Institute of Complex Systems, Cellular Biophysics, ICS-4, Forschungszentrum
      Julich GmbH, Julich, Germany.
FAU - Rosch, Sarah
AU  - Rosch S
AD  - Department of Ophthalmology, RWTH Aachen University, Aachen, Germany.
FAU - Thumann, Gabriele
AU  - Thumann G
AD  - Department of Ophthalmology, RWTH Aachen University, Aachen, Germany.
FAU - Muller, Frank
AU  - Muller F
AD  - Institute of Complex Systems, Cellular Biophysics, ICS-4, Forschungszentrum
      Julich GmbH, Julich, Germany.
FAU - Walter, Peter
AU  - Walter P
AD  - Department of Ophthalmology, RWTH Aachen University, Aachen, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171227
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - *Disease Models, Animal
MH  - Electric Stimulation
MH  - Mice
MH  - Microelectrodes
MH  - Retinal Degeneration/*physiopathology
PMC - PMC5744965
EDAT- 2017/12/28 06:00
MHDA- 2018/02/07 06:00
CRDT- 2017/12/28 06:00
PHST- 2017/08/04 00:00 [received]
PHST- 2017/12/07 00:00 [accepted]
PHST- 2017/12/28 06:00 [entrez]
PHST- 2017/12/28 06:00 [pubmed]
PHST- 2018/02/07 06:00 [medline]
AID - 10.1371/journal.pone.0190048 [doi]
AID - PONE-D-17-28728 [pii]
PST - epublish
SO  - PLoS One. 2017 Dec 27;12(12):e0190048. doi: 10.1371/journal.pone.0190048.
      eCollection 2017.