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Relationship between Topoisomerase II Alpha Overexpression and Prognosis in Chinese Gastric Cancer Patients.

Abstract The aim of this study was to investigate topoisomerase II alpha (TOP2α) overexpression and its association with clinicopathological features and prognosis in gastric cancer (GC) patients. All selected GC patients at Affiliated Hospital of Qinghai University and Cancer Hospital, Chinese Academy of Medical Sciences, between December 2009 and December 2011, had formalin-fixed and paraffin-embedded tumor tissues. The patients received a telephone follow-up or in-/outpatient review, and their clinicopathological features and prognoses were analyzed. Also, the relationship between TOP2α expression and postoperative chemotherapy in GC patients was estimated. The results of the study showed that TOP2α overexpression correlated with location of tumor, depth of invasion, and pTNM stage. Moreover, it was associated with lower 5-year overall survival (OS) in noncardia GC patients younger than 60 years, with multivariate analysis demonstrating that it was an independent prognostic factor for these patients. Univariate analysis and multivariate analysis showed that TOP2α overexpression was associated with worse 5-year OS in noncardia GC patients ≤ 60 years receiving postoperative chemotherapy. TOP2α overexpression exhibited associations with location of tumor, depth of invasion, pTNM stage, and postoperative chemotherapy, making it a potential target for early diagnosis of GC patients. In addition, TOP2α overexpression was shown to be a predictor of 5-year OS in both noncardia GC patients ≤ 60 years and noncardia GC patients ≤ 60 years and receiving postoperative chemotherapy.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title journal of environmental pathology, toxicology and oncology : official organ of the international society for environmental toxicology and cancer
Publication Year Start




PMID- 29283334
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20180104
IS  - 2162-6537 (Electronic)
IS  - 0731-8898 (Linking)
VI  - 36
IP  - 3
DP  - 2017
TI  - Relationship between Topoisomerase II Alpha Overexpression and Prognosis in
      Chinese Gastric Cancer Patients.
PG  - 207-216
LID - 10.1615/JEnvironPatholToxicolOncol.2017018602 [doi]
AB  - The aim of this study was to investigate topoisomerase II alpha (TOP2alpha)
      overexpression and its association with clinicopathological features and
      prognosis in gastric cancer (GC) patients. All selected GC patients at Affiliated
      Hospital of Qinghai University and Cancer Hospital, Chinese Academy of Medical
      Sciences, between December 2009 and December 2011, had formalin-fixed and
      paraffin-embedded tumor tissues. The patients received a telephone follow-up or
      in-/outpatient review, and their clinicopathological features and prognoses were 
      analyzed. Also, the relationship between TOP2alpha expression and postoperative
      chemotherapy in GC patients was estimated. The results of the study showed that
      TOP2alpha overexpression correlated with location of tumor, depth of invasion,
      and pTNM stage. Moreover, it was associated with lower 5-year overall survival
      (OS) in noncardia GC patients younger than 60 years, with multivariate analysis
      demonstrating that it was an independent prognostic factor for these patients.
      Univariate analysis and multivariate analysis showed that TOP2alpha
      overexpression was associated with worse 5-year OS in noncardia GC patients </=
      60 years receiving postoperative chemotherapy. TOP2alpha overexpression exhibited
      associations with location of tumor, depth of invasion, pTNM stage, and
      postoperative chemotherapy, making it a potential target for early diagnosis of
      GC patients. In addition, TOP2alpha overexpression was shown to be a predictor of
      5-year OS in both noncardia GC patients </= 60 years and noncardia GC patients
      </= 60 years and receiving postoperative chemotherapy.
FAU - Zheng, Fangchao
AU  - Zheng F
AD  - Affiliated Hospital of Qinghai University, Qinghai University, Xining, China.
FAU - Zhao, Jiuda
AU  - Zhao J
AD  - Affiliated Hospital of Qinghai University, Qinghai University, Xining, China;
      Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese
      Academy of Medical Sciences, Beijing, China.
FAU - Du, Feng
AU  - Du F
AD  - Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese
      Academy of Medical Sciences, Beijing, China.
FAU - Zhao, Junhui
AU  - Zhao J
AD  - Affiliated Hospital of Qinghai University, Qinghai University, Xining, China.
FAU - Shen, Guoshuang
AU  - Shen G
AD  - Affiliated Hospital of Qinghai University, Qinghai University, Xining, China.
FAU - Ma, Fei
AU  - Ma F
AD  - Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese
      Academy of Medical Sciences, Beijing, China.
FAU - Ma, Xinfu
AU  - Ma X
AD  - Affiliated Hospital of Qinghai University, Qinghai University, Xining, China.
FAU - Dong, Li
AU  - Dong L
AD  - Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese
      Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021,
      China.
FAU - Ma, Wei
AU  - Ma W
AD  - Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese
      Academy of Medical Sciences, Beijing, China.
FAU - Shen, Cunfang
AU  - Shen C
AD  - Affiliated Hospital of Qinghai University, Qinghai University, Xining, China.
FAU - Wang, Shuyan
AU  - Wang S
AD  - Affiliated Hospital of Qinghai University, Qinghai University, Xining, China.
FAU - Ma, Jinhua
AU  - Ma J
AD  - Affiliated Hospital of Qinghai University, Qinghai University, Xining, China.
FAU - Luo, Yang
AU  - Luo Y
AD  - Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese
      Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021,
      China.
FAU - Wang, Ziyi
AU  - Wang Z
AD  - Affiliated Hospital of Qinghai University, Qinghai University, Xining, China.
FAU - Xu, Binghe
AU  - Xu B
AD  - Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese
      Academy of Medical Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Environ Pathol Toxicol Oncol
JT  - Journal of environmental pathology, toxicology and oncology : official organ of
      the International Society for Environmental Toxicology and Cancer
JID - 8501420
RN  - EC 5.99.1.3 (DNA Topoisomerases, Type II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Combined Modality Therapy
MH  - DNA Topoisomerases, Type II/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Stomach Neoplasms/enzymology/*mortality/pathology/therapy
EDAT- 2017/12/29 06:00
MHDA- 2018/01/05 06:00
CRDT- 2017/12/29 06:00
PHST- 2017/12/29 06:00 [entrez]
PHST- 2017/12/29 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
AID - 1828aa871383557b,48a5c471100e33ce [pii]
AID - 10.1615/JEnvironPatholToxicolOncol.2017018602 [doi]
PST - ppublish
SO  - J Environ Pathol Toxicol Oncol. 2017;36(3):207-216. doi:
      10.1615/JEnvironPatholToxicolOncol.2017018602.