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Photothermal Therapy Employing Gold Nanoparticle- Loaded Macrophages as Delivery Vehicles: Comparing the Efficiency of Nanoshells Versus Nanorods.

Abstract Macrophages (Ma) loaded with gold based nanoparticles, which convert near infrared light to heat, have been studied as targeted transport vectors for photothermal therapy (PTT) of tumors. The purpose of the experiments reported here was to compare the efficacy of gold-silica nanoshells (AuNS) and gold nanorods (AuNR) in macrophage mediated PTT. PTT efficacy was evaluated in hybrid glioma spheroids consisting of human glioma cells and either AuNS or AuNR loaded Ma, designated MaNS and MaNR respectivly. Spheroids were irradiated for 10 min. with light from an 810 nm diode laser at irradiances ranging from 0 to 28 W/cm2. PTT efficacy was determined from spheroid growth over a 14-day period. The uptake by Ma of pegylated AuNR (3.9 ± 0.9 %) was twice that of pegylated AuNS, (7.9 ± 0.7 %). Hybrid spheroids consisting of a 5:1 ratio of glioma cells to loaded Ma exhibited significant growth inhibition with MaNS when subjected to irradiances of 7 W/cm2 or greater. In contrast, no significant growth inhibition was observed for the MaNR hybrid spheroids at this 5:1 ratio, even at the highest irradiance investigated (28 W/cm2). Although AuNR were taken up by Ma in larger numbers then AuNS, MaNS were shown to have greater PTT efficacy compared to MaNR for equivalent numbers of loaded Ma.
PMID
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Authors

Mayor MeshTerms

Macrophages

Nanotubes

Keywords
Journal Title journal of environmental pathology, toxicology and oncology : official organ of the international society for environmental toxicology and cancer
Publication Year Start




PMID- 29283336
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20180104
IS  - 2162-6537 (Electronic)
IS  - 0731-8898 (Linking)
VI  - 36
IP  - 3
DP  - 2017
TI  - Photothermal Therapy Employing Gold Nanoparticle- Loaded Macrophages as Delivery 
      Vehicles: Comparing the Efficiency of Nanoshells Versus Nanorods.
PG  - 229-235
LID - 10.1615/JEnvironPatholToxicolOncol.2017021545 [doi]
AB  - Macrophages (Ma) loaded with gold based nanoparticles, which convert near
      infrared light to heat, have been studied as targeted transport vectors for
      photothermal therapy (PTT) of tumors. The purpose of the experiments reported
      here was to compare the efficacy of gold-silica nanoshells (AuNS) and gold
      nanorods (AuNR) in macrophage mediated PTT. PTT efficacy was evaluated in hybrid 
      glioma spheroids consisting of human glioma cells and either AuNS or AuNR loaded 
      Ma, designated MaNS and MaNR respectivly. Spheroids were irradiated for 10 min.
      with light from an 810 nm diode laser at irradiances ranging from 0 to 28 W/cm2. 
      PTT efficacy was determined from spheroid growth over a 14-day period. The uptake
      by Ma of pegylated AuNR (3.9 +/- 0.9 %) was twice that of pegylated AuNS, (7.9
      +/- 0.7 %). Hybrid spheroids consisting of a 5:1 ratio of glioma cells to loaded 
      Ma exhibited significant growth inhibition with MaNS when subjected to
      irradiances of 7 W/cm2 or greater. In contrast, no significant growth inhibition 
      was observed for the MaNR hybrid spheroids at this 5:1 ratio, even at the highest
      irradiance investigated (28 W/cm2). Although AuNR were taken up by Ma in larger
      numbers then AuNS, MaNS were shown to have greater PTT efficacy compared to MaNR 
      for equivalent numbers of loaded Ma.
FAU - Christie, Catherine
AU  - Christie C
AD  - Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences
      Rd. E, Irvine, CA 92612.
FAU - Madsen, Steen J
AU  - Madsen SJ
AD  - Department of Health Physics and Diagnostic Sciences, University of Nevada, Las
      Vegas, 4505 S. Maryland Pkwy., Box 453037, Las Vegas, NV 89154.
FAU - Peng, Qian
AU  - Peng Q
AD  - Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital,
      Montebello, 0310 Oslo, Norway.
FAU - Hirschberg, Henry
AU  - Hirschberg H
AD  - Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences
      Rd. E, Irvine, CA 92612.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Environ Pathol Toxicol Oncol
JT  - Journal of environmental pathology, toxicology and oncology : official organ of
      the International Society for Environmental Toxicology and Cancer
JID - 8501420
RN  - 0 (Pharmaceutical Vehicles)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Animals
MH  - Brain Neoplasms/*therapy
MH  - Cell Line
MH  - Cell Line, Tumor
MH  - Glioma/*therapy
MH  - Gold/*administration & dosage
MH  - Humans
MH  - Hyperthermia, Induced/*methods
MH  - *Macrophages
MH  - Metal Nanoparticles/*administration & dosage
MH  - Mice
MH  - Nanoshells/*administration & dosage
MH  - *Nanotubes
MH  - Pharmaceutical Vehicles
MH  - Phototherapy/*methods
EDAT- 2017/12/29 06:00
MHDA- 2018/01/05 06:00
CRDT- 2017/12/29 06:00
PHST- 2017/12/29 06:00 [entrez]
PHST- 2017/12/29 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
AID - 1828aa871383557b,58c9dcc61793769b [pii]
AID - 10.1615/JEnvironPatholToxicolOncol.2017021545 [doi]
PST - ppublish
SO  - J Environ Pathol Toxicol Oncol. 2017;36(3):229-235. doi:
      10.1615/JEnvironPatholToxicolOncol.2017021545.