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KAI1/CD82, Metastasis Suppressor Gene as a Therapeutic Target for Non-Small-Cell Lung Carcinoma.

Abstract Lung cancer is the most frequent malignancy and the leading cause of cancer-related death worldwide; it is the second most common cancer, comprising 1.69 million deaths worldwide per year. Among these, 85% of lung cancers are non-small-cell lung carcinoma (NSCLC). Metastasis is common in NSCLC patients and are responsible for most deaths. Kang-Ai 1 (KAI1), a tumor metastasis suppressor gene also known as Cluster of Differentiation 82 (CD82), is a member of the membrane tetraspanin protein family, which are capable of inhibiting the metastatic process in NSCLC. KAI1/CD82 suppresses metastasis via multiple mechanisms regulating inhibition of cell motility, adhesion, fusion, and proliferation. KAI1 may attenuate signaling to shut down metastatic colonization through attenuation of epidermal growth factor receptor (EGFR) signaling and inhibition of the Wnt signaling pathways. In this review, we focus on the differential expression of KAI1/CD82, a tumor metastasis suppressor gene that can inhibit cancer invasion and cell metastasis during NSCLC. The differential expression of KAI1/CD82 could prove to be of novel therapeutic significance in treating malignant tumors and in reducing their metastatic potential.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title journal of environmental pathology, toxicology and oncology : official organ of the international society for environmental toxicology and cancer
Publication Year Start




PMID- 29283339
OWN - NLM
STAT- In-Process
LR  - 20171228
IS  - 2162-6537 (Electronic)
IS  - 0731-8898 (Linking)
VI  - 36
IP  - 3
DP  - 2017
TI  - KAI1/CD82, Metastasis Suppressor Gene as a Therapeutic Target for Non-Small-Cell 
      Lung Carcinoma.
PG  - 269-275
LID - 10.1615/JEnvironPatholToxicolOncol.2017024619 [doi]
AB  - Lung cancer is the most frequent malignancy and the leading cause of
      cancer-related death worldwide; it is the second most common cancer, comprising
      1.69 million deaths worldwide per year. Among these, 85% of lung cancers are
      non-small-cell lung carcinoma (NSCLC). Metastasis is common in NSCLC patients and
      are responsible for most deaths. Kang-Ai 1 (KAI1), a tumor metastasis suppressor 
      gene also known as Cluster of Differentiation 82 (CD82), is a member of the
      membrane tetraspanin protein family, which are capable of inhibiting the
      metastatic process in NSCLC. KAI1/CD82 suppresses metastasis via multiple
      mechanisms regulating inhibition of cell motility, adhesion, fusion, and
      proliferation. KAI1 may attenuate signaling to shut down metastatic colonization 
      through attenuation of epidermal growth factor receptor (EGFR) signaling and
      inhibition of the Wnt signaling pathways. In this review, we focus on the
      differential expression of KAI1/CD82, a tumor metastasis suppressor gene that can
      inhibit cancer invasion and cell metastasis during NSCLC. The differential
      expression of KAI1/CD82 could prove to be of novel therapeutic significance in
      treating malignant tumors and in reducing their metastatic potential.
FAU - Prabhu, Venugopal Vinod
AU  - Prabhu VV
AD  - Department of Biochemistry, University of Madras, Guindy campus, Chennai-600025, 
      Tamil Nadu, India.
FAU - Devaraj, S Niranjali
AU  - Devaraj SN
AD  - Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600025, 
      Tamil Nadu, India.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Environ Pathol Toxicol Oncol
JT  - Journal of environmental pathology, toxicology and oncology : official organ of
      the International Society for Environmental Toxicology and Cancer
JID - 8501420
EDAT- 2017/12/29 06:00
MHDA- 2017/12/29 06:00
CRDT- 2017/12/29 06:00
PHST- 2017/12/29 06:00 [entrez]
PHST- 2017/12/29 06:00 [pubmed]
PHST- 2017/12/29 06:00 [medline]
AID - 1828aa871383557b,7b62392c438e98f6 [pii]
AID - 10.1615/JEnvironPatholToxicolOncol.2017024619 [doi]
PST - ppublish
SO  - J Environ Pathol Toxicol Oncol. 2017;36(3):269-275. doi:
      10.1615/JEnvironPatholToxicolOncol.2017024619.