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Chemometric evaluation of concentrations of trace elements in intervertebral disc tissue in patient with degenerative disc disease.

Abstract The work is designed to uncover the pattern of mutual relation among trace elements and epidemiological data in the degenerated intervertebral disk tissue in humans. Hitherto the reason of the degenerative process is not fully understood. Trace elements are the basic components of the biological compound related both its metabolism as well as environmental exposure. The relation pattern among elements occurs gives new perspective in solving the cause of the disease.
PMID
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Authors

Mayor MeshTerms
Keywords

Intervertebral Disk

chemometrics

degeneration

trace elements

Journal Title annals of agricultural and environmental medicine : aaem
Publication Year Start




PMID- 29284234
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20180105
IS  - 1898-2263 (Electronic)
IS  - 1232-1966 (Linking)
VI  - 24
IP  - 4
DP  - 2017 Dec 23
TI  - Chemometric evaluation of concentrations of trace elements in intervertebral disc
      tissue in patient with degenerative disc disease.
PG  - 610-617
LID - 72574 [pii]
LID - 10.5604/12321966.1232555 [doi]
AB  - BACKGROUND: The work is designed to uncover the pattern of mutual relation among 
      trace elements and epidemiological data in the degenerated intervertebral disk
      tissue in humans. Hitherto the reason of the degenerative process is not fully
      understood. Trace elements are the basic components of the biological compound
      related both its metabolism as well as environmental exposure. The relation
      pattern among elements occurs gives new perspective in solving the cause of the
      disease. MATERIAL AND METHODS: We have analysed trace elements content in the 30 
      intervertebral disc from 22 patients with degenerative disc disease. The
      concentrations of Al, Cu, Cd, Mo, Ni and Pb were determined with Atomic
      Absorption Spectrometry. To analyse the multidimentional relation between trace
      element concentration and epidemiological data the chemometric analysis was
      applied. RESULTS: The similarity have been shown in occurrence of following
      pairs: Cd-Mo as well as Mg-Zn. The second pair was correlated with Pb
      concentration. Pb levels are observed to be competitive to Cu concentration. Cd
      concentration was related to Zn and Mg deficiency. No single but rather cluster
      of epidemiological data show observable influence on the TE tissue variance. Zn
      and Cu was related to the male sex. Operation with orthopedic implants were
      related to combined Al, Mo and Zn concentration. CONCLUSIONS: This is the first
      chemometric analysis of trace elements in disk tissue. It shows multidimentional 
      relations that are missed by the classical statistic. The analysis shows
      significant relation. The nature of the relations is the basis for further
      metabolic and environmental research.
FAU - Kubaszewski, Lukasz
AU  - Kubaszewski L
AD  - Department of Orthopaedic and Traumatology, W. Dega University Hospital,
      University of Medical Sciences, Poznan, Poland. [email protected]
FAU - Ziola-Frankowska, Anetta
AU  - Ziola-Frankowska A
AD  - Faculty of Chemistry, Adam Mickiewicz University in Poznan, Poland.
FAU - Gasik, Zuzanna
AU  - Gasik Z
AD  - Clinic and Polyclinic of Neuro-orthopedic and Neurology, Institute of
      Rheumatology, Warsaw, Poland.
FAU - Frankowski, Marcin
AU  - Frankowski M
AD  - Faculty of Chemistry, Adam Mickiewicz University in Poznan, Poland.
FAU - Dabrowski, Mikolaj
AU  - Dabrowski M
AD  - Department of Spondyloorthopaedics and Biomechanics of the Spine, Poznan
      University of Medical Sciences, Poland.
FAU - Molisak, Bartlomiej
AU  - Molisak B
AD  - Department of Orthopaedic and Traumatology, W. Dega University Hospital,
      University of Medical Sciences, Poznan, Poland.
FAU - Kaczmarczyk, Jacek
AU  - Kaczmarczyk J
AD  - Department of Orthopaedic and Traumatology, W. Dega University Hospital,
      University of Medical Sciences, Poznan, Poland.
FAU - Gasik, Robert
AU  - Gasik R
AD  - Clinic and Polyclinic of Neuro-orthopedic and Neurology, Institute of
      Rheumatology, Warsaw, Poland.
LA  - eng
PT  - Journal Article
DEP - 20170511
PL  - Poland
TA  - Ann Agric Environ Med
JT  - Annals of agricultural and environmental medicine : AAEM
JID - 9500166
RN  - 0 (Trace Elements)
RN  - 2P299V784P (Lead)
RN  - 789U1901C5 (Copper)
RN  - CPD4NFA903 (Aluminum)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Adult
MH  - Aluminum/analysis/metabolism
MH  - Copper/analysis/metabolism
MH  - Female
MH  - Humans
MH  - Intervertebral Disc/*chemistry/metabolism
MH  - Intervertebral Disc Degeneration/*metabolism
MH  - Lead/analysis/metabolism
MH  - Male
MH  - Middle Aged
MH  - Spectrophotometry, Atomic
MH  - Trace Elements/*analysis/metabolism
MH  - Zinc/analysis/metabolism
OTO - NOTNLM
OT  - Intervertebral Disk
OT  - chemometrics
OT  - degeneration
OT  - trace elements
EDAT- 2017/12/30 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/12/30 06:00
PHST- 2017/12/30 06:00 [entrez]
PHST- 2017/12/30 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
AID - 72574 [pii]
AID - 10.5604/12321966.1232555 [doi]
PST - ppublish
SO  - Ann Agric Environ Med. 2017 Dec 23;24(4):610-617. doi: 10.5604/12321966.1232555. 
      Epub 2017 May 11.