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PMID- 29298331
OWN - NLM
STAT- MEDLINE
DCOM- 20180206
LR  - 20180206
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 1
DP  - 2018
TI  - Detection of artificial pulmonary lung nodules in ultralow-dose CT using an ex
      vivo lung phantom.
PG  - e0190501
LID - 10.1371/journal.pone.0190501 [doi]
AB  - OBJECTIVES: To assess the image quality of 3 different ultralow-dose CT protocols
      on pulmonary nodule depiction in a ventilated ex vivo-system. MATERIALS AND
      METHODS: Four porcine lungs were inflated inside a dedicated chest phantom and
      prepared with n = 195 artificial nodules (0.5-1 mL). The artificial chest wall
      was filled with water to simulate the absorption of a human chest. Images were
      acquired with a 2x192-row detector CT using low-dose (reference protocol with a
      tube voltage of 120 kV) and 3 different ULD protocols (respective effective
      doses: 1mSv and 0.1mSv). A different tube voltage was used for each ULD protocol:
      70kV, 100kV with tin filter (100kV_Sn) and 150kV with tin filter (150kV_Sn).
      Nodule delineation was assessed by two observers (scores 1-5, 1 = unsure, 5 =
      high confidence). RESULTS: The diameter of the 195 detected artificial nodules
      ranged from 0.9-21.5 mm (mean 7.84 mm +/- 5.31). The best ULD scores were
      achieved using 100kV_Sn and 70 kV ULD protocols (4.14 and 4.06 respectively).
      Both protocols were not significantly different (p = 0.244). The mean score of
      3.78 in ULD 150kV_Sn was significantly lower compared to the 100kV_Sn ULD
      protocol (p = 0.008). CONCLUSION: The results of this experiment, conducted in a 
      realistic setting show the feasibility of ultralow-dose CT for the detection of
      pulmonary nodules.
FAU - Burgard, Caroline Alexandra
AU  - Burgard CA
AUID- ORCID: 0000-0003-1522-8860
AD  - Department of Clinical Radiology, University Hospital Munich,
      Ludwig-Maximilians-University, Munich, Germany.
FAU - Gaass, Thomas
AU  - Gaass T
AD  - Department of Clinical Radiology, University Hospital Munich,
      Ludwig-Maximilians-University, Munich, Germany.
AD  - Comprehensive Pneumology Center, German Center for Lung Research, Munich,
      Germany.
AD  - German Cancer Research Center, Division of Medical Physics in Radiology,
      Heidelberg, Germany.
FAU - Bonert, Madeleine
AU  - Bonert M
AD  - Department of Clinical Radiology, University Hospital Munich,
      Ludwig-Maximilians-University, Munich, Germany.
FAU - Bondesson, David
AU  - Bondesson D
AD  - Department of Clinical Radiology, University Hospital Munich,
      Ludwig-Maximilians-University, Munich, Germany.
FAU - Thaens, Natalie
AU  - Thaens N
AD  - Department of Clinical Radiology, University Hospital Munich,
      Ludwig-Maximilians-University, Munich, Germany.
AD  - Comprehensive Pneumology Center, German Center for Lung Research, Munich,
      Germany.
AD  - German Cancer Research Center, Division of Medical Physics in Radiology,
      Heidelberg, Germany.
FAU - Reiser, Maximilian Ferdinand
AU  - Reiser MF
AD  - Department of Clinical Radiology, University Hospital Munich,
      Ludwig-Maximilians-University, Munich, Germany.
FAU - Dinkel, Julien
AU  - Dinkel J
AD  - Department of Clinical Radiology, University Hospital Munich,
      Ludwig-Maximilians-University, Munich, Germany.
AD  - Comprehensive Pneumology Center, German Center for Lung Research, Munich,
      Germany.
AD  - German Cancer Research Center, Division of Medical Physics in Radiology,
      Heidelberg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20180103
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - *Phantoms, Imaging
MH  - *Radiation Dosage
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Solitary Pulmonary Nodule/*diagnostic imaging
MH  - Swine
MH  - Tomography, X-Ray Computed/*methods
PMC - PMC5752031
EDAT- 2018/01/04 06:00
MHDA- 2018/02/07 06:00
CRDT- 2018/01/04 06:00
PHST- 2017/02/28 00:00 [received]
PHST- 2017/12/16 00:00 [accepted]
PHST- 2018/01/04 06:00 [entrez]
PHST- 2018/01/04 06:00 [pubmed]
PHST- 2018/02/07 06:00 [medline]
AID - 10.1371/journal.pone.0190501 [doi]
AID - PONE-D-17-07835 [pii]
PST - epublish
SO  - PLoS One. 2018 Jan 3;13(1):e0190501. doi: 10.1371/journal.pone.0190501.
      eCollection 2018.