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Tungiasis-related life quality impairment in children living in rural Kenya.

Abstract Tungiasis (sand flea disease) is a neglected tropical skin disease caused by female sand fleas (Tunga spp.) embedded in the skin of the host. The disease is common in sub-Saharan Africa and predominantly affects children living in impoverished rural communities. In these settings tungiasis is associated with important morbidity. Whether tungiasis impairs life quality has never been studied.
PMID
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Authors

Mayor MeshTerms

Quality of Life

Keywords
Journal Title plos neglected tropical diseases
Publication Year Start




PMID- 29309411
OWN - NLM
STAT- MEDLINE
DCOM- 20180130
LR  - 20180210
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 12
IP  - 1
DP  - 2018 Jan
TI  - Tungiasis-related life quality impairment in children living in rural Kenya.
PG  - e0005939
LID - 10.1371/journal.pntd.0005939 [doi]
AB  - BACKGROUND: Tungiasis (sand flea disease) is a neglected tropical skin disease
      caused by female sand fleas (Tunga spp.) embedded in the skin of the host. The
      disease is common in sub-Saharan Africa and predominantly affects children living
      in impoverished rural communities. In these settings tungiasis is associated with
      important morbidity. Whether tungiasis impairs life quality has never been
      studied. METHODS: The study was performed in 50 children with tungiasis, living
      in resource-poor communities in coastal Kenya. Based on the Dermatology Life
      Quality Index (DLQI) a tool was developed to determine life quality impairment
      associated with tungiasis in children, the tungiasis-related Dermatology of Life 
      Quality Index (tungiasis-related-DLQI). Pain and itching were assessed using
      visual scales ranging from 0-3 points. The intensity of infection and the acute
      and chronic severity of tungiasis were determined using standard methods.
      RESULTS: Seventy eight percent of the patients reported a moderate to very large 
      effect of tungiasis on life quality at the time of the diagnosis. The degree of
      impairment correlated with the number of viable sand fleas present in the skin
      (rho = 0.64, p < 0.001), the severity score of acute clinical pathology (rho =
      0.74, p < 0.001), and the intensity of pain (rho = 0.82, p < 0.001). Disturbance 
      of sleep and concentration difficulties were the most frequent restriction
      categories (86% and 84%, respectively). Four weeks after curative treatment, life
      quality had improved significantly. On the individual level the amelioration of
      life quality correlated closely with the regression of clinical pathology (rho = 
      0.61, p < 0.001). CONCLUSION: The parasitic skin disease tungiasis considerably
      impairs life quality in children in rural Kenya. After effective treatment, life 
      quality improves rapidly.
FAU - Wiese, Susanne
AU  - Wiese S
AUID- ORCID: 0000-0001-6136-7015
AD  - Institute of Microbiology and Hygiene, University Medicine Berlin, Germany.
FAU - Elson, Lynne
AU  - Elson L
AD  - WAJIMIDA Jigger Campaign, Dabaso Tujengane CBO, Watamu, Kenya.
FAU - Feldmeier, Hermann
AU  - Feldmeier H
AD  - Institute of Microbiology and Hygiene, University Medicine Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180108
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Kenya
MH  - Male
MH  - Pain/*parasitology
MH  - Pain Measurement
MH  - Pruritus/*parasitology
MH  - *Quality of Life
MH  - Rural Population
MH  - Sleep Wake Disorders/*parasitology
MH  - Treatment Outcome
MH  - Tunga/drug effects
MH  - Tungiasis/drug therapy/parasitology/*pathology
PMC - PMC5757912
EDAT- 2018/01/09 06:00
MHDA- 2018/01/31 06:00
CRDT- 2018/01/09 06:00
PHST- 2017/02/24 00:00 [received]
PHST- 2017/09/06 00:00 [accepted]
PHST- 2018/01/09 06:00 [entrez]
PHST- 2018/01/09 06:00 [pubmed]
PHST- 2018/01/31 06:00 [medline]
AID - 10.1371/journal.pntd.0005939 [doi]
AID - PNTD-D-17-00282 [pii]
PST - epublish
SO  - PLoS Negl Trop Dis. 2018 Jan 8;12(1):e0005939. doi: 10.1371/journal.pntd.0005939.
      eCollection 2018 Jan.