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Tetrodotoxin (TTX) Monitoring of Biological Specimens and Toxin Profile in a Food Poisoning Case Caused by the Scavenging Gastropod Nassarius (Alectrion) glans "Kinshibai".

Abstract In November 2015, a patient presented with symptoms of toxicity after eating whole boiled samples of the scavenging gastropod Nassarius (Alectrion) glans "Kinshibai" in Nagasaki. This food poisoning case was the third recorded in Japan. The case was investigated by evaluation of the toxin profile of the gastropod, and monitoring of tetrodotoxin (TTX) levels in serum and urine sampled from the affected individual. One gastropod contained a harmful dose of TTX (2.5 mg/ individual in food residue sample 2). In biological samples, maximum TTX concentrations were 42.8 ng/mL in serum on the day after onset of symptoms. TTX urinary excretion was calculated to be 2.4 mg. From the measured TTX concentrations, it was estimated that a lethal dose had been ingested in this case. Moreover, it was found by LC-QqQ-MS/MS analysis and mouse bioassay that the toxicity of "Kinshibai" was not solely due to TTX. The remaining toxicity was thought to be due to 11-oxoTTX. As in previous poisoning cases, it was concluded that ingestion of this gastropod poses a high risk of food poisoning.
PMID
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Toxicity and toxin profile of tetrodotoxin detected in the scavenging gastropod Nassarius (Alectrion) glans "Kinshibai".

Authors

Mayor MeshTerms

Gastropoda

Keywords

11-oxoTTX

LC-QTOF-MS/MS

LC-QqQ-MS/MS

Nassarius (Alectrion) glans

Tetrodotoxin

food poisoning

serum

urine

Journal Title shokuhin eiseigaku zasshi. journal of the food hygienic society of japan
Publication Year Start




PMID- 29311444
OWN - NLM
STAT- MEDLINE
DCOM- 20180123
LR  - 20180123
IS  - 1882-1006 (Electronic)
IS  - 0015-6426 (Linking)
VI  - 58
IP  - 6
DP  - 2017
TI  - [Tetrodotoxin (TTX) Monitoring of Biological Specimens and Toxin Profile in a
      Food Poisoning Case Caused by the Scavenging Gastropod Nassarius (Alectrion)
      glans "Kinshibai"].
PG  - 253-259
LID - 10.3358/shokueishi.58.253 [doi]
AB  - In November 2015, a patient presented with symptoms of toxicity after eating
      whole boiled samples of the scavenging gastropod Nassarius (Alectrion) glans
      "Kinshibai" in Nagasaki. This food poisoning case was the third recorded in
      Japan. The case was investigated by evaluation of the toxin profile of the
      gastropod, and monitoring of tetrodotoxin (TTX) levels in serum and urine sampled
      from the affected individual. One gastropod contained a harmful dose of TTX (2.5 
      mg/ individual in food residue sample 2). In biological samples, maximum TTX
      concentrations were 42.8 ng/mL in serum on the day after onset of symptoms. TTX
      urinary excretion was calculated to be 2.4 mg. From the measured TTX
      concentrations, it was estimated that a lethal dose had been ingested in this
      case. Moreover, it was found by LC-QqQ-MS/MS analysis and mouse bioassay that the
      toxicity of "Kinshibai" was not solely due to TTX. The remaining toxicity was
      thought to be due to 11-oxoTTX. As in previous poisoning cases, it was concluded 
      that ingestion of this gastropod poses a high risk of food poisoning.
FAU - Tsujimura, Kazunari
AU  - Tsujimura K
AD  - Nagasaki Prefectural Institute of Environment and Public Health.
FAU - Yoshimura, Hiroki
AU  - Yoshimura H
AD  - Nagasaki Prefectural Institute of Environment and Public Health.
FAU - Taguri, Toshitsugu
AU  - Taguri T
AD  - Nagasaki Prefectural Institute of Environment and Public Health.
FAU - Motomura, Hideaki
AU  - Motomura H
AD  - Nagasaki Prefectural Institute of Environment and Public Health.
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Shokuhin Eiseigaku Zasshi
JT  - Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan
JID - 0142214
RN  - 0 (Biomarkers)
RN  - 4368-28-9 (Tetrodotoxin)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Biological Assay/methods
MH  - Biomarkers/blood/urine
MH  - Chromatography, Liquid/methods
MH  - Food Analysis/methods
MH  - Foodborne Diseases/*diagnosis/*etiology
MH  - *Gastropoda/chemistry
MH  - Humans
MH  - Japan
MH  - Male
MH  - Mice
MH  - Monitoring, Physiologic/methods
MH  - Risk
MH  - Tandem Mass Spectrometry/methods
MH  - Tetrodotoxin/analysis/*blood/*urine
OTO - NOTNLM
OT  - 11-oxoTTX
OT  - LC-QTOF-MS/MS
OT  - LC-QqQ-MS/MS
OT  - Nassarius (Alectrion) glans
OT  - Tetrodotoxin
OT  - food poisoning
OT  - serum
OT  - urine
EDAT- 2018/01/10 06:00
MHDA- 2018/01/24 06:00
CRDT- 2018/01/10 06:00
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/01/24 06:00 [medline]
AID - 10.3358/shokueishi.58.253 [doi]
PST - ppublish
SO  - Shokuhin Eiseigaku Zasshi. 2017;58(6):253-259. doi: 10.3358/shokueishi.58.253.