PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Serological and molecular inquiry of Chagas disease in an Afro-descendant settlement in Mato Grosso do Sul State, Brazil.

Abstract Furnas do Dionísio is a Brazilian Afro-descendant settlement in the city of Jaraguari, 21.4 miles from Campo Grande, Mato Grosso do Sul, Brazil. Approximately 96 families live in this quilombola (Maroon) settlement, also known in Brazil as a remnant community of descendants of African slaves. Recent studies found 20% of households were infested by triatomines, 18% of insects captured in the community were infected by Trypanosoma cruzi, and 22.7% of dogs presented T. cruzi antibodies. The low prevalence of Chagas disease observed in humans in Mato Grosso do Sul State is attributed to its arrival via colonist migration and subsequent transplacental transmission. In order to gain a better understanding of the T. cruzi cycle in residents of the study community, serological and molecular tests were carried out to diagnose Chagas disease. In the present study, 175 residents between 2 and 80 years old were included. A total of 175 participants were interviewed and 170 provided blood samples, which were tested for T. cruzi antibodies with serological tests. Molecular diagnosis was performed in 167 participants by PCR (KDNA) and NPCR (satellite DNA) tests. One of the 170 samples tested positive for all serological tests performed. The overall frequency of Chagas disease in the community was low (0.6%). Interview responses revealed that 66.3% knew of triatomine insects and 65.7% reported having had no contact with them. Physical improvements to residences, together with vector surveillance and control by the State and municipal governments and local ecological conservation contribute to the low frequency of the Chagas disease in this quilombola community.
PMID
Related Publications

On the possibility of autochthonous Chagas disease in Roraima, Amazon region, Brazil, 2000-2001.

Chagas' disease in the Brazilian Amazon. III. A cross-sectional study (1).

Monitoring Trypanosoma cruzi infection in triatomines using PCR in Mato Grosso do Sul, Brazil.

Chagas' disease in the southern coastal region of Brazil.

Epidemiological factors related to the transmission risk of Trypanosoma cruzi in a Quilombola community, State of Mato Grosso do Sul, Brazil.

Authors

Mayor MeshTerms

African Continental Ancestry Group

Keywords
Journal Title plos one
Publication Year Start




PMID- 29315305
OWN - NLM
STAT- MEDLINE
DCOM- 20180129
LR  - 20180129
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 1
DP  - 2018
TI  - Serological and molecular inquiry of Chagas disease in an Afro-descendant
      settlement in Mato Grosso do Sul State, Brazil.
PG  - e0189448
LID - 10.1371/journal.pone.0189448 [doi]
AB  - Furnas do Dionisio is a Brazilian Afro-descendant settlement in the city of
      Jaraguari, 21.4 miles from Campo Grande, Mato Grosso do Sul, Brazil.
      Approximately 96 families live in this quilombola (Maroon) settlement, also known
      in Brazil as a remnant community of descendants of African slaves. Recent studies
      found 20% of households were infested by triatomines, 18% of insects captured in 
      the community were infected by Trypanosoma cruzi, and 22.7% of dogs presented T. 
      cruzi antibodies. The low prevalence of Chagas disease observed in humans in Mato
      Grosso do Sul State is attributed to its arrival via colonist migration and
      subsequent transplacental transmission. In order to gain a better understanding
      of the T. cruzi cycle in residents of the study community, serological and
      molecular tests were carried out to diagnose Chagas disease. In the present
      study, 175 residents between 2 and 80 years old were included. A total of 175
      participants were interviewed and 170 provided blood samples, which were tested
      for T. cruzi antibodies with serological tests. Molecular diagnosis was performed
      in 167 participants by PCR (KDNA) and NPCR (satellite DNA) tests. One of the 170 
      samples tested positive for all serological tests performed. The overall
      frequency of Chagas disease in the community was low (0.6%). Interview responses 
      revealed that 66.3% knew of triatomine insects and 65.7% reported having had no
      contact with them. Physical improvements to residences, together with vector
      surveillance and control by the State and municipal governments and local
      ecological conservation contribute to the low frequency of the Chagas disease in 
      this quilombola community.
FAU - Martins, Mariana Furquim da Silva
AU  - Martins MFDS
AD  - Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade
      Estadual de Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
FAU - Pereira, Mariane Barroso
AU  - Pereira MB
AD  - Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade
      Estadual de Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
FAU - Ferreira, Juliana de Jesus Guimaraes
AU  - Ferreira JJG
AD  - Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade
      Estadual de Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
FAU - Franca, Adriana de Oliveira
AU  - Franca AO
AD  - Centro de Ciencias Biologicas e da Saude, Faculdade de Farmacia, Universidade
      Federal de Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, Brazil.
FAU - Cominetti, Marlon Cezar
AU  - Cominetti MC
AD  - Centro de Ciencias Biologicas e da Saude, Faculdade de Farmacia, Universidade
      Federal de Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, Brazil.
FAU - Ferreira, Eduardo de Castro
AU  - Ferreira EC
AD  - Universidade Anhanguera UNIDERP, Campo Grande, Mato Grosso do Sul, Brazil.
AD  - FIOCRUZ Mato Grosso do Sul, Fundacao Oswaldo Cruz, Campo Grande, Mato Grosso do
      Sul, Brazil.
FAU - Dorval, Maria Elizabeth Moraes Cavalheiros
AU  - Dorval MEMC
AD  - Centro de Ciencias Biologicas e da Saude, Faculdade de Farmacia, Universidade
      Federal de Mato Grosso do Sul (UFMS), Campo Grande, Mato Grosso do Sul, Brazil.
FAU - Rossi, Claudio Lucio
AU  - Rossi CL
AD  - Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade
      Estadual de Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
FAU - Mazon, Silvia de Barros
AU  - Mazon SB
AD  - Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade
      Estadual de Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
FAU - de Almeida, Eros Antonio
AU  - de Almeida EA
AD  - Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade
      Estadual de Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
FAU - Costa, Sandra Cecilia Botelho
AU  - Costa SCB
AD  - Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade
      Estadual de Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
FAU - Marcon, Glaucia Elisete Barbosa
AU  - Marcon GEB
AD  - FIOCRUZ Mato Grosso do Sul, Fundacao Oswaldo Cruz, Campo Grande, Mato Grosso do
      Sul, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180109
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antibodies, Protozoan)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *African Continental Ancestry Group
MH  - Antibodies, Protozoan/blood
MH  - Brazil/epidemiology
MH  - Chagas Disease/blood/*epidemiology/genetics
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Seroepidemiologic Studies
MH  - Trypanosoma cruzi/genetics/immunology
MH  - Young Adult
PMC - PMC5760030
EDAT- 2018/01/10 06:00
MHDA- 2018/01/30 06:00
CRDT- 2018/01/10 06:00
PHST- 2017/04/06 00:00 [received]
PHST- 2017/11/24 00:00 [accepted]
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/01/30 06:00 [medline]
AID - 10.1371/journal.pone.0189448 [doi]
AID - PONE-D-17-34451 [pii]
PST - epublish
SO  - PLoS One. 2018 Jan 9;13(1):e0189448. doi: 10.1371/journal.pone.0189448.
      eCollection 2018.