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Mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced cardiovascular toxicity: An overview.

Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant and its toxicity is mediated by the aryl hydrocarbon receptor (AHR). Mechanisms of TCDD cardiovascular toxicity consist of oxidative stress, growth factor modulation, and ionic current alteration. It is indicated that the rodent cardiovascular system is a target for TCDD cardiomyopathy. Here, our understanding of TCDD cardiovascular toxicity is reviewed.
PMID
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Authors

Mayor MeshTerms
Keywords

Aryl hydrocarbon receptor

Cardiovascular dysfunction

Dioxin

TCDD

Journal Title chemico-biological interactions
Publication Year Start




PMID- 29317249
OWN - NLM
STAT- MEDLINE
DCOM- 20180209
LR  - 20180209
IS  - 1872-7786 (Electronic)
IS  - 0009-2797 (Linking)
VI  - 282
DP  - 2018 Feb 25
TI  - Mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced cardiovascular
      toxicity: An overview.
PG  - 1-6
LID - S0009-2797(17)30442-8 [pii]
LID - 10.1016/j.cbi.2018.01.002 [doi]
AB  - 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant and
      its toxicity is mediated by the aryl hydrocarbon receptor (AHR). Mechanisms of
      TCDD cardiovascular toxicity consist of oxidative stress, growth factor
      modulation, and ionic current alteration. It is indicated that the rodent
      cardiovascular system is a target for TCDD cardiomyopathy. Here, our
      understanding of TCDD cardiovascular toxicity is reviewed.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Mohsenzadeh, Mahdieh Sadat
AU  - Mohsenzadeh MS
AD  - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad
      University of Medical Sciences, Mashhad, P.O. Box, 91375-345, Iran.
FAU - Zanjani, Bamdad Riahi
AU  - Zanjani BR
AD  - Medical Toxicology Research Center, School of Medicine, Mashhad University of
      Medical Sciences, Mashhad, P.O. Box, 91375-345, Iran.
FAU - Karimi, Gholamreza
AU  - Karimi G
AD  - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad
      University of Medical Sciences, Mashhad, P.O. Box, 91375-345, Iran;
      Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad
      University of Medical Sciences, Mashhad, P.O. Box, 91375-345, Iran. Electronic
      address: [email protected]
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180106
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Polychlorinated Dibenzodioxins)
SB  - IM
MH  - Animals
MH  - Cardiotoxicity/*etiology
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/metabolism
MH  - Oxidative Stress/drug effects
MH  - Polychlorinated Dibenzodioxins/*adverse effects
OTO - NOTNLM
OT  - Aryl hydrocarbon receptor
OT  - Cardiovascular dysfunction
OT  - Dioxin
OT  - TCDD
EDAT- 2018/01/11 06:00
MHDA- 2018/02/10 06:00
CRDT- 2018/01/11 06:00
PHST- 2017/04/27 00:00 [received]
PHST- 2017/12/05 00:00 [revised]
PHST- 2018/01/05 00:00 [accepted]
PHST- 2018/01/11 06:00 [pubmed]
PHST- 2018/02/10 06:00 [medline]
PHST- 2018/01/11 06:00 [entrez]
AID - S0009-2797(17)30442-8 [pii]
AID - 10.1016/j.cbi.2018.01.002 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2018 Feb 25;282:1-6. doi: 10.1016/j.cbi.2018.01.002. Epub
      2018 Jan 6.