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Field effectiveness of highly pathogenic avian influenza H5N1 vaccination in commercial layers in Indonesia.

Abstract Although vaccination of poultry for control of highly pathogenic avian influenza virus (HPAIV) H5N1 has been practiced during the last decade in several countries, its effectiveness under field conditions remains largely unquantified. Effective HPAI vaccination is however essential in preventing incursions, silent infections and generation of new H5N1 antigenic variants. The objective of this study was to asses the level and duration of vaccine induced immunity in commercial layers in Indonesia. Titres of H5N1 haemagglutination inhibition (HI) antibodies were followed in individual birds from sixteen flocks, age 18-68 week old (wo). The study revealed that H5N1 vaccination had highly variable outcome, including vaccination failures, and was largely ineffective in providing long lasting protective immunity. Flocks were vaccinated with seven different vaccines, administer at various times that could be grouped into three regimes: In regime A, flocks (n = 8) were vaccinated two or three times before 19 wo; in regime B (n = 2), two times before and once after 19 wo; and in regime C (n = 6) three to four times before and two to three times after 19 wo. HI titres in regime C birds were significantly higher during the entire observation period in comparison to titres of regime A or B birds, which also differed significantly from each other. The HI titres of individual birds in each flock differed significantly from birds in other flocks, indicating that the effectiveness of field vaccination was highly variable and farm related. Protective HI titres of >4log2, were present in the majority of flocks at 18 wo, declined thereafter at variable rate and only two regime C flocks had protective HI titres at 68 wo. Laboratory challenge with HPAIV H5N1 of birds from regime A and C flocks confirmed that protective immunity differed significantly between flocks vaccinated by these two regimes. The study revealed that effectiveness of the currently applied H5N1 vaccination could be improved and measures to achieve this are discussed.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos one
Publication Year Start




PMID- 29320563
OWN - NLM
STAT- In-Data-Review
LR  - 20180110
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 1
DP  - 2018
TI  - Field effectiveness of highly pathogenic avian influenza H5N1 vaccination in
      commercial layers in Indonesia.
PG  - e0190947
LID - 10.1371/journal.pone.0190947 [doi]
AB  - Although vaccination of poultry for control of highly pathogenic avian influenza 
      virus (HPAIV) H5N1 has been practiced during the last decade in several
      countries, its effectiveness under field conditions remains largely unquantified.
      Effective HPAI vaccination is however essential in preventing incursions, silent 
      infections and generation of new H5N1 antigenic variants. The objective of this
      study was to asses the level and duration of vaccine induced immunity in
      commercial layers in Indonesia. Titres of H5N1 haemagglutination inhibition (HI) 
      antibodies were followed in individual birds from sixteen flocks, age 18-68 week 
      old (wo). The study revealed that H5N1 vaccination had highly variable outcome,
      including vaccination failures, and was largely ineffective in providing long
      lasting protective immunity. Flocks were vaccinated with seven different
      vaccines, administer at various times that could be grouped into three regimes:
      In regime A, flocks (n = 8) were vaccinated two or three times before 19 wo; in
      regime B (n = 2), two times before and once after 19 wo; and in regime C (n = 6) 
      three to four times before and two to three times after 19 wo. HI titres in
      regime C birds were significantly higher during the entire observation period in 
      comparison to titres of regime A or B birds, which also differed significantly
      from each other. The HI titres of individual birds in each flock differed
      significantly from birds in other flocks, indicating that the effectiveness of
      field vaccination was highly variable and farm related. Protective HI titres of
      >4log2, were present in the majority of flocks at 18 wo, declined thereafter at
      variable rate and only two regime C flocks had protective HI titres at 68 wo.
      Laboratory challenge with HPAIV H5N1 of birds from regime A and C flocks
      confirmed that protective immunity differed significantly between flocks
      vaccinated by these two regimes. The study revealed that effectiveness of the
      currently applied H5N1 vaccination could be improved and measures to achieve this
      are discussed.
FAU - Tarigan, Simson
AU  - Tarigan S
AUID- ORCID: http://orcid.org/0000-0002-2024-1456
AD  - Indonesian Research Centre for Veterinary Science, Bogor, Indonesia.
FAU - Wibowo, Michael Haryadi
AU  - Wibowo MH
AD  - Faculty of Veterinary Science, Universitas Gadjah Mada, Yogyakarta, Indonesia.
FAU - Indriani, Risa
AU  - Indriani R
AD  - Indonesian Research Centre for Veterinary Science, Bogor, Indonesia.
FAU - Sumarningsih, Sumarningsih
AU  - Sumarningsih S
AD  - Indonesian Research Centre for Veterinary Science, Bogor, Indonesia.
FAU - Artanto, Sidna
AU  - Artanto S
AD  - Faculty of Veterinary Science, Universitas Gadjah Mada, Yogyakarta, Indonesia.
FAU - Idris, Syafrison
AU  - Idris S
AD  - Directorate General of Livestock and Animal Health Services, Jakarta, Indonesia.
FAU - Durr, Peter A
AU  - Durr PA
AD  - CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.
FAU - Asmara, Widya
AU  - Asmara W
AD  - Faculty of Veterinary Science, Universitas Gadjah Mada, Yogyakarta, Indonesia.
FAU - Ebrahimie, Esmaeil
AU  - Ebrahimie E
AD  - School of Information Technology and Mathematical Sciences, Division of
      Information Technology, Engineering and the Environment, University of South
      Australia, Adelaide, South Australia, Australia.
FAU - Stevenson, Mark A
AU  - Stevenson MA
AD  - School of Veterinary and Agricultural Sciences, University of Melbourne,
      Melbourne, Victoria, Australia.
FAU - Ignjatovic, Jagoda
AU  - Ignjatovic J
AD  - School of Veterinary and Agricultural Sciences, University of Melbourne,
      Melbourne, Victoria, Australia.
LA  - eng
PT  - Journal Article
DEP - 20180110
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
EDAT- 2018/01/11 06:00
MHDA- 2018/01/11 06:00
CRDT- 2018/01/11 06:00
PHST- 2017/06/22 00:00 [received]
PHST- 2017/12/24 00:00 [accepted]
PHST- 2018/01/11 06:00 [entrez]
PHST- 2018/01/11 06:00 [pubmed]
PHST- 2018/01/11 06:00 [medline]
AID - 10.1371/journal.pone.0190947 [doi]
AID - PONE-D-17-23768 [pii]
PST - epublish
SO  - PLoS One. 2018 Jan 10;13(1):e0190947. doi: 10.1371/journal.pone.0190947.
      eCollection 2018.